Clinical trials: Cardio Pulmonary Bypass
to Study the Effect of Vitamin C Administration on the Amount and the Time of Weaning of Noradrenaline Given Post-operatively to Patients After CPB
Role of Vitamin C in Cardiac Vasoplegia After Cardiopulmonary Bypass
This is a parallel group double-blind, randomized-controlled trial with 1:1 randomization ratio which will be conducted over a period of 6 months to study the effect of vitamin C administration on the amount of noradrenaline…
- Trial name
- NCT04519281
- Testing
- IV of vitamin C
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Acute Kidney Injury
Bicarbonate in Cardiac Surgery
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- NCT00878956
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 427 people
- Sponsor
- Austin Health
Elective Cardiac Surgery
Microcirculation of the Thenar Eminence
Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome.
- Trial name
- NCT01748266
- Testing
- microcirculatory reactivity
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Valve Disease, Coronary Artery Disease
RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery
Heart surgery involving valve replacement often involves the use of the heart-lung machine for over 90 minutes, and bleeding tendency is frequently seen.
- Trial name
- RiaCT (NCT01283321)
- Testing
- Human fibrinogen concentrate, apheresis platelets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Cardiopulmonary Bypass, Lactate
Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries
Tissue hypoperfusion during cardiopulmonary bypass (CPB) affects cardiac surgical outcomes. Lactate, an end product of anaerobic glycolysis from oxygen deficit, is an obtainable marker of tissue hypoxia.
- Trial name
- NCT03934892
- Testing
- serum lactate
- Volunteers
- 97 people
- Sponsor
- Hualien Tzu Chi General Hospital
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
ICU Stay
Assessment of OHIR Score to Predict a Prolonged Intensive Care Unit Stay
A prolonged stay in intensive care unit (ICU) after cardiac surgery with cardiopulmonary bypass increases not only cost of patient care but also morbidity and mortality of patients.
- Trial name
- NCT02945358
- Testing
- adult cardiac surgery with cardiopulmonary pump
- Where
- 2 sites in Thailand
- Volunteers
- 120 people
- Sponsor
- Khon Kaen University
Stroke, Cardiac Surgery
Effect of Minimally Invasive Extracorporeal Circulation on Optic Nerve Sheath Diameter and Stroke Incidence in Isolated Open Heart Surgery
This prospective randomized controlled trial compares the effects of Minimally Invasive Extracorporeal Circulation (MiECC) versus conventional cardiopulmonary bypass (CPB) on optic nerve sheath diameter (ONSD) and postoperative…
- Conditions
- Stroke, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- ONSD-MiECC (NCT07661238)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Pulmonary Hypertension
Inhaled Milrinone in Cardiac Surgery
The purpose of this study is to investigate the concentration-effect relationship of inhaled milrinone after prophylactic administration in cardiac surgical patients with preoperative pulmonary hypertension undergoing…
- Trial name
- NCT01725776
- Testing
- Inhaled milrinone 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
Hemostasis
Three Dose Regimen of Tranexamic Acid in Cardiac Surgery
Tranexamic acid is thought to be a promising substitute for aprotinin when the latter has seceded in 2007. Yet the ideal dosage and dosing regimen of tranexamic acid in cardiopulmonary bypass cardiac surgery in Chinese population…
- Trial name
- NCT01060176
- Testing
- Tranexamic Acid, Saline Solution
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ultrasound, Pectoral Nerve Block
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane…
- Conditions
- Ultrasound, Pectoral Nerve Block, Transverse Thoracic Plane Block, Pediatric Patients
- Trial name
- NCT06984276
- Testing
- Control, Pectoral nerves (PECS), Transversus thoracic muscle plane block (TTPB)
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Cardiac Surgery, Congenital Heart Disease
Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery.
- Conditions
- Cardiac Surgery, Congenital Heart Disease, Cardiopulmonary Bypass, Fibrinogenemia
- Trial name
- NCT05525195
- Testing
- Congenital cardiac surgery
- Where
- Belgium
- Volunteers
- 932 people
- Sponsor
- Brugmann University Hospital
Right Heart Failure, Right Ventricular Dysfunction
Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
In cardiac surgery, the presence of pulmonary hypertension (PH) is a prognostic factor associated with increased mortality and morbidity.
- Trial name
- MILAN (NCT05450328)
- Testing
- Combined Epoprostenol Sodium & Milrinone, Normal saline
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Congenital Heart Disease
The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates
This is an observational, prospective study to evaluate the role of tranexamic acid in reducing blood transfusion in neonates undergoing cardiopulmonary bypass.
- Trial name
- NCT01914211
- Testing
- Tranexamic Acid, Acute Normovolemic Hemodilution
- Where
- United States
- Sponsor
- Aymen N Naguib
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Congenital Heart Disease, Intestinal Disease
Effect of Probiotics on Patients With Congenital Heart Disease Following Cardiopulmonary Bypass
A randomized, controlled study including infants with non-cyanosis congenital heart disease (CHD) in need of surgical correction involving cardiopulmonary bypass (CPB) was established.
- Conditions
- Congenital Heart Disease, Intestinal Disease, Dysbiosis
- Trial name
- NCT06295575
- Testing
- probiotics containing Bifidobacterium infantis and Lactobacillus
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Children's Hospital
Postoperative Delirium (POD), Cardiopulmonary Bypass
Effect of Low Tidal Volume Ventilation on Postoperative Delirium
This study aims to evaluate the effect of low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) on postoperative delirium.
- Conditions
- Postoperative Delirium (POD), Cardiopulmonary Bypass, Low Tidal Volume Ventilation, Cognitive Dysfunction, Postoperative
- Trial name
- CLEVER (NCT06752421)
- Testing
- Group B: Low tidal volume
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Nevsehir Public Hospital
Heart Surgical Procedure
Blood Velocity Variation in Right Renal and Superior Mesenteric Arteries During Cardio-pulmonary Bypass
The cardiopulmonary by-pass technique, used in cardiac surgery to obtain a bloodless operating field and an immobile heart, determines important effects on the blood vessel wall, especially when a continuous and non-continuous…
- Trial name
- NCT06009809
- Testing
- transesophageal echocardiogram
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Kidney Injury Cardiac Surgery
Renal Near-Infrared Spectroscopy Monitoring and Postoperative Acute Kidney Injury in Cardiac Surgery
This prospective observational study aims to evaluate the effectiveness of renal near-infrared spectroscopy (NIRS) monitoring in predicting postoperative acute kidney injury (AKI) in patients undergoing elective cardiac surgery…
- Trial name
- RENAL-CPB-NIRS (NCT07582393)
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- SERAY TÜRKMEN