Clinical trials: Cardio Pulmonary Bypass
Airway Ultrasound, Airway Edema
Cuff Pressure and Airway Edema in CABG With CPB
This study investigates how endotracheal tube (ETT) cuff pressure management during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) affects upper airway edema.
- Conditions
- Airway Ultrasound, Airway Edema, Endotracheal Tube
- Trial name
- NCT07148024
- Testing
- ETT cuff pressure 0 mmHg, ETT cuff pressure 20-30 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Engin Çetin
Cardiac Surgical Procedures, Coronary Artery Bypass
Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery
TALEN is a prospective randomised double-blind placebo-controlled phase 2 study of 5-Aminolevulinic Acid with Sodium Ferrous Citrate (5-ALA-SFC) in adult patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Bypass, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- TALEN (NCT07027670)
- Testing
- 5-Aminolevulinic Acid hydrochloride (5-ALA), Sodium ferrous citrate (SFC)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Postoperative Complications
Cardiopulmonary Exercise Testing in Cardiosurgery Patients
Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery.
- Trial name
- NCT06702059
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in Czechia
- Volunteers
- 130 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Hypogammaglobulinemia, Congenital Heart Disease
Post-bypass Prophylactic IVIG in Infants and Neonates
The purpose of this study protocol is to determine if administering Intravenous Immunoglobulin (IVIG) for treatment of cardiopulmonary bypass (CPB) induced hypogammaglobulinemia in the early post-operative period can impact…
- Trial name
- NCT02043379
- Testing
- IVIG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Postoperative Cognitive Dysfunction, Delirium, Postoperative
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures.
- Trial name
- NCT07000461
- Testing
- Transcranial Doppler measurement of the middle cerebral artery
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Acute Circulatory Failure
Microcirculatory Effects of Methylene Blue
International guidelines recommend Methylene Blue (MB) as a second-line drug in the treatment of norepinephrine refractory vasoplegic shock (VS) after Cardiopulmonary Bypass CPB.
- Trial name
- MAGIC BLUE (NCT04250389)
- Testing
- Hemodynamic assessment (micro and macrocirculatory)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Healthy, Coronary Artery Bypass Graft
Cardioprotective Effects of Increased Endogenous Erythropoietin After Normobaric Oxygen Breathing
Tissue hypoxia is the only accepted trigger for erythropoietin (EPO) production. However, in healthy subjects EPO concentrations have also increased after oxygen breathing. The aim of our study is to confirm these observations.
- Trial name
- NCT00824759
- Testing
- pure oxygen breathing versus air
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Congenital Heart Disease, Cardiopulmonary Bypass
Seattle Cardiorenal Remote Ischemic Preconditioning Trial
Remote Ischemic Preconditioning (RIPC) is a treatment that may be associated with improved outcomes after cardiac surgery. It can be elicited noninvasively by using a tourniquet to elicit transient ischemia over a lower…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Myocardial Injury, Acute Kidney Injury
- Trial name
- SCRIPT (NCT01260259)
- Testing
- RIPC, Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Seattle Children's Hospital
Novel Biomarkers of Acute Kidney Injury Following Cardiac Surgery
Biomarkers of Acute Kidney Injury Following Cardiac Surgery
Acute kidney injury occurs in up to 30% of patients undergoing cardiac surgery. Cardiac surgery associated-acute kidney injury (CSA-AKI) is characterized by a sudden and sustained decrease in renal function with insufficient…
- Trial name
- NCT04387149
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Saskatchewan
Postoperative Complications
Crystalloids vs Albumin Prime Solution and Postoperative Pulmonary Complications
In 2019, the investigators initiated a new priming fluid therapy strategy in the cardiopulmonary bypass (CPB) machine for patients undergoing pulmonary endarterectomy surgery.
- Trial name
- ALBUTEP (NCT04839432)
- Testing
- implementation of albumin solution in the priming of the cardiopulmonary bypass machine
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Erasme University Hospital
Coronary Disease
Platelet Activation Markers in Pediatric Cardiac Surgery
In this study the focus will be on correlating the levels of platelet activation markers (proteins that are released when blood cells are activated)to the duration of cardiopulmonary bypass, temperature during cardiopulmonary…
- Trial name
- NCT00450151
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Open Heart Surgery
Dose for Reversal of Heparin After Cardiopulmonary Bypass
Protamine sulfate is routinely used to reverse heparin anticoagulation after cardiopulmonary bypass (CPB). The conventional dosing strategy of 1 mg protamine per 100 IU of heparin may result in excess protamine exposure, which…
- Trial name
- NCT07477977
- Testing
- Protamine sulfate
- Where
- Egypt
- Volunteers
- 195 people
- Sponsor
- Sohag University
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Hemodynamic Instability
Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level
Hemodynamic parameters and lactate level will be on CBP during CABG surgery patients.
- Trial name
- NCT05004545
- Testing
- Propofol
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Atrial Fibrillation
Prevention of Atrial Fibrillation Following Valvular Replacement With Cardiopulmonary Bypass: a Prospective, Randomized Clinical Study Comparing Oral Caffeine With Placebo
Atrial fibrillation remains a major cause of morbidity following cardiac surgery with cardiopulmonary bypass. Many mechanisms have been implicated.
- Trial name
- NCT01999829
- Testing
- citrate of caffeine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury
The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury, Congenital Heart Defect
- Trial name
- NCT06899971
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Surgery, Cardiac Event
Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
Oxiris membrane is an efficient tool for inflammatory cytokines adsorption. Cardiac surgery is followed by an inflammatory state mimicking sepsis.
- Trial name
- OXICARD (NCT04201119)
- Testing
- Oxiris
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Frailty, Cardiac Surgery
SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older
The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients…
- Conditions
- Frailty, Cardiac Surgery, QALYs
- Trial name
- SAGE-Heart (NCT07677319)
- Testing
- Phone Calls
- Where
- France
- Volunteers
- 265 people
- Sponsor
- University Hospital, Bordeaux