Clinical trials: Cardio-Respiratory Failure
Cardiorespiratory Failure
Harnessing Alternative Resources to Aid Kenyans With Acute Illness
Kenya does not have enough experts to perform heart scans in patients who are very sick and in need of urgent intervention. The purpose of this research is to find out whether training Kenyan nurses to perform basic heart scans…
- Trial name
- HARAKA-2 (NCT04344418)
- Testing
- Nurse-performed Focused cardiac ultrasound (FoCUS), Usual care
- Volunteers
- 732 people
- Sponsor
- Aga Khan University
Heart Failure, Myocardial Infarction
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
INVESTED will test the hypothesis that high dose trivalent influenza vaccine will reduce cardiopulmonary events to a greater extent than standard dose quadrivalent influenza vaccine in high-risk cardiovascular patients with a…
- Trial name
- INVESTED (NCT02787044)
- Testing
- High Dose Trivalent Influenza Vaccine, Standard Dose Quadrivalent Influenza Vaccine
- Where
- 190 sites in United States, Canada and 1 more
- Volunteers
- 5,388 people
- Sponsor
- Brigham and Women's Hospital
Cardiopulmonary Failure
Safety, Feasibility and Clinical Utility of Critical Care Transesophageal Echocardiography in Hong Kong
Critical care echocardiography is increasingly recognized as an essential skill for intensivists to achieve during their training and fellowship.
- Trial name
- SAFE-TEE (NCT06178471)
- Testing
- Transesophageal Echocardiography
- Sponsor
- Queen Mary Hospital, Hong Kong
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Indication of Orotracheal Intubation, Cardio Respiratory Arrest
Comparative Evaluation of the McGrath Videolaryngoscope and the Direct Laryngoscopy for Tracheal Intubation in the Prehospital Setting
In the prehospital setting, the risk of difficult intubation and life-threatening complications is increased under particular conditions due to the environment or the frequent instability of patients.
- Conditions
- Indication of Orotracheal Intubation, Cardio Respiratory Arrest, Respiratory Failure, Neurological Failure
- Trial name
- AMAC (NCT04930419)
- Testing
- Videolaryngoscopy group, Direct laryngoscopy group
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Insufficiency, Respiratory Failure
Novel Non-Invasive Monitoring Parameter in a Hospital Setting
Data collected from this study will be used to evaluate the performance of a monitoring algorithm.
- Trial name
- NCT01306201
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Medtronic - MITG
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Cardiorespiratory Failure
Optimizing a Mobile Mindfulness Intervention for ICU Survivors
This is a factorial experimental trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is conceptualized as the Optimization Phase of a multiphase optimization strategy (MOST)…
- Trial name
- LIFT2 (NCT04038567)
- Testing
- Mobile mindfulness-based training
- Where
- 3 sites in United States
- Volunteers
- 247 people
- Sponsor
- Duke University
Respiratory Insufficiency
BIPAP Vision Versus OPTIFLOW System Comparison in Acute Respiratory Failure After Cardio Thoracic Surgery
The OPTIFLOW ™ use is becoming more common in acute respiratory failure cases, but its place in relation to VNI (Bi-PAP mode) is not yet defined.
- Trial name
- OPTIFLOW (NCT01458444)
- Testing
- Non invasive ventilation (VNI), Non invasive ventilation
- Where
- France
- Volunteers
- 830 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Cardiopulmonary Failure
Evaluation of Ultrasound of the Heart in Patients With Low Blood Pressure
Hypothesis: Goal-directed echocardiography by trained critical care physicians is equivalent to that of echocardiography technicians/cardiologists for the purpose of determining etiology (reason) of cardiopulmonary failure.
- Trial name
- NCT01723176
- Testing
- Echocardiography
- Where
- United States
- Sponsor
- Northwell Health
Inpatient Facililty Diagnoses
Wireless Monitoring for Clinical Deterioration
The study evaluates whether implementing a wireless monitoring system for patients admitted to hospital wards reduces mortality and cardiopulmonary failure.
- Trial name
- i-PROTECT (NCT06644599)
- Testing
- wireless monitoring
- Where
- Saudi Arabia
- Volunteers
- 13,160 people
- Sponsor
- King Abdullah International Medical Research Center
Heart Failure, Copd
The DIVERT-CARE (Collaboration Action Research & Evaluation) Trial
Rationale: In Canada, home care clients are a large and expanding subgroup of medically complex older adults with relatively poor access to effective chronic disease management.
- Trial name
- DIVERT-CARE (NCT03012256)
- Testing
- Cardio-respiratory management model
- Where
- 3 sites in Canada
- Volunteers
- 896 people
- Sponsor
- McMaster University
Respiratory Failure, Pneumothorax
Driving Pressure And EFL in Adult Cardiac Surgery
During general anesthesia, functional residual capacity (FRC) is reduced. If the FRC is lower than the minimum volume required to maintain the opening of the airways, there is a derecruitment of the lung parenchyma, leading to…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Respiratory Infection
- Trial name
- NCT03064659
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Ospedale San Raffaele
Cardio-Respiratory Failure, Extracorporeal Membrane Oxygenation Complication
Safety and Performance of the Novalung Ultimate Kit and Xenios 2.0 During Stationary Use in Hospital and Ground-based Transport of Patients on Extracorporeal Life Support (ECLS)
This prospective observational study will evaluate the safety and performance of the Novalung ultimate kit in combination with the Xenios 2.0 and the MultiSupport Ground during stationary use in hospital and ground-based…
- Conditions
- Cardio-Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Acute Lung Injury
- Trial name
- Transport+ (NCT07156669)
- Testing
- Novalung ultimate kit, Xenios 2.0, and MultiSupport Ground (MSG)
- Where
- 3 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Xenios AG
Cardiovascular Health, Breast Cancer
JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year
This study focuses on male and female patients being treated for breast cancer that is positive for the HER2 receptor which requires special treatments targeting that receptor.
- Conditions
- Cardiovascular Health, Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Cardio-oncology
- Trial name
- JUSTIFY (NCT06930521)
- Testing
- Intervention - Low Risk Group OR Intermediate Risk Group
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Women's College Hospital
Respiratory Failure, Pneumothorax
Mechanical Ventilation During Cardiac Surgery
Background There is no unanimous opinion about a lung-protective strategy in cardiac surgery. Small randomized clinical and animals trials suggest that ventilation during cardio-pulmonary bypass (CPB) could be protective on the…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Aspiration Pneumonia
- Trial name
- NCT02090205
- Testing
- Non-ventilation during CPB, Ventilation with CPAP, Ventilation with 5 act/minute
- Where
- 13 sites in Italy
- Volunteers
- 780 people
- Sponsor
- Ospedale San Raffaele
Cardiorespiratory Failure
Mobile Coping Skills Training to Improve Cardiorespiratory Failure Survivors' Psychological Distress
This is a pilot randomized clinical trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is designed to test the acceptability, feasibility, and clinical impact of a coping…
- Trial name
- Blueprint (NCT04329702)
- Testing
- Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Depression, Anxiety
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common.
- Conditions
- Depression, Anxiety, Post-traumatic Stress Disorder, Stress
- Trial name
- Blueprint 2 (NCT06538246)
- Testing
- Blueprint, Education program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Pulmonary Hypertension, Cardiorenal Syndrome
Predictive Value of Renal Venous Flow Profiles for Adverse Outcomes in Right Heart Failure
Predictive value of renal venous flow profiles for adverse outcomes in patients with right heart failure
- Conditions
- Pulmonary Hypertension, Cardiorenal Syndrome, Heart Failure
- Trial name
- NCT03039959
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 421 people
- Sponsor
- University of Giessen