Clinical trials: Cardiogenic Shock Acute
Cardiogenic Shock
Unloading in Heart Failure Cardiogenic Shock
The purpose of this research study is to evaluate whether timely and aggressive temporary Mechanical Circulatory Support (tMCS) through the Impella 5.5® in patients with acute decompensated heart failure complicated by…
- Trial name
- UNLOAD HF-CS (NCT05064202)
- Testing
- Impella 5.5, Inotropes
- Where
- 5 sites in Netherlands
- Volunteers
- 456 people
- Sponsor
- Amsterdam UMC, location VUmc
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Acute Myocardial Infarction Complicated With Cardiogenic Shock
Multidisciplinary Collaborative Care System for Acute Myocardial Infarction Complicated With Cardiogenic Shock
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) represents the most life-threatening subtype of acute cardiovascular diseases.
- Trial name
- AMICS-Reg (NCT07470814)
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Study of Immunity Dysfunction Induced by Extracorporeal Assistance (ECMO / ECLS)
Study of immunosuppression biomarkers in patients with ARDS or cardiogenic shock with ECMO / ECLS, compared to patients with ARDS or cardiogenic shock without ECMO / ECLS
- Trial name
- IMPEC (NCT03262155)
- Testing
- Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Cardiogenic Shock, Acute; Myocardial Infarction, Complications
Carolinas Cardiogenic Shock Initiative
To determine if deferred or delayed implantation of Impella device based on shock severity index is non-inferior with respect to 1 month and 1 year mortality compared to standard clinical protocols that do not differentiate based…
- Trial name
- CCSI (NCT04985708)
- Testing
- data collection of clinically available procedures
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Cardiogenic Shock
Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function.
Long term prognosis of cardiogenic shock is related to the resolution of haemodynamic failure, associated visceral failure and the recovery of an adequate myocardial function.
- Trial name
- EMPASHOCK (NCT05879276)
- Testing
- Empagliflozin 10 MG
- Where
- 8 sites in France
- Volunteers
- 164 people
- Sponsor
- Central Hospital, Nancy, France
Acute Myocardial Infarction, Cardiogenic Shock
Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction
Multicenter, international, randomized, placebo-controlled, double-blind trial comparing intravenous cangrelor and crushed oral ticagrelor in patients with acute myocardial infarction complicated by initial cardiogenic shock…
- Trial name
- DAPT-SHOCK-AMI (NCT03551964)
- Testing
- Cangrelor, Ticagrelor
- Where
- 29 sites in Czechia, France and 3 more
- Volunteers
- 605 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Cardiogenic Shock Acute
Early Preventive Left Ventricle Unloading After VA-ECMO for Refractory Cardiogenic Shock
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used worldwide to treat severe cardiogenic shock.
- Trial name
- EULODIA (NCT07027202)
- Testing
- Early Left Ventricle unloading
- Where
- 12 sites in France
- Volunteers
- 298 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock Acute, Acute Myocardial Infarction
Danish Cardiogenic Shock Trial
Cardiogenic shock a serious complication of a heart attack (myocardial infarction). Despite rapid invasive treatment, circulatory support using positive inotropes and mechanical support with intra-aortic balloon counterpulsation…
- Trial name
- DanShock (NCT01633502)
- Testing
- Conventional circulatory support, Impella CP
- Where
- 13 sites in Denmark, Germany and 1 more
- Volunteers
- 360 people
- Sponsor
- Odense University Hospital
Cardiogenic Shock Acute, Cardiogenic Shock
Cardiovascular Outcomes Registry in Cardiogenic SHOCK (COR-SHOCK)
The goal of this observational study is to evaluate the clinical outcomes and management approaches of cardiogenic shock throughout the years in adult patients admitted to a Cardiology Department.
- Conditions
- Cardiogenic Shock Acute, Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- COR-SHOCK (NCT07597291)
- Where
- Portugal
- Volunteers
- 800 people
- Sponsor
- Hospital de Santa Cruz, Portugal
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France
Myocarditis, Myocarditis Acute
Outcome of Clinical Phenotypes of Pediatric Myocarditis at Assiut University Children Hospital
This study aims to investigate the clinical phenotypes, management approaches, and outcomes of myocarditis in children admitted to Assiut University Children's Hospital.
- Trial name
- PED-MYO (NCT07175948)
- Testing
- Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Shock, Cardiogenic
A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack
Tilarginine Acetate Injection is a new type of drug that temporarily stops the body from making a bodily substance called nitric oxide. The body may produce excess nitric oxide following severe heart damage leading to shock.
- Trial name
- NCT00112281
- Testing
- Tilarginine Acetate Injection intravenous infusion
- Where
- 102 sites in United States, Canada
- Volunteers
- 658 people
- Sponsor
- Arginox Pharmaceuticals
Myocardial Infarction, Heart Failure
Levosimendan in Acute Heart Failure Following Acute Myocardial Infarction.
The purpose of this study is to determine the safety and efficacy of a 24 hour infusion with levosimendan in patients with acute myocardial infarction and heart failure after acute percutaneous coronary intervention (PCI)…
- Conditions
- Myocardial Infarction, Heart Failure, Cardiogenic Shock
- Trial name
- NCT00324766
- Testing
- levosimendan
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Oslo University Hospital
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cardiogenic Shock, Cardiac Arrest
China Extracorporeal Life Support Registry
Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective cardiac and respiratory support to patients with lungs and/or heart failure.
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04158479
- Testing
- ECMO
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Impact of ECMO Cannula Chlorhexidine-impregnated Dressings to Decrease Extracorporeal Membrane Oxygenation-cannula Related Infection Rate
The Dressing-ECMO trial is a prospective, open-label, multicenter, controlled trial randomizing patients who received percutaneous ECMO to cannula chlorhexidine-impregnated dressing vs standard dressing.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome, Infections
- Trial name
- DRESSING-ECMO (NCT05750576)
- Testing
- Chlorhexidine-impregnated dressings, Non impregnated dressings
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris