Clinical trials: Cardiometabolic Conditions
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections
Lifestyle, Dietary Patterns, and Cardiometabolic Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Among People Living With HIV
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, is an increasingly recognized comorbidity in people living with human immunodeficiency virus (HIV).
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections, Non-Alcoholic Fatty Liver Disease, Liver Cirrhosis
- Trial name
- NCT07861594
- Volunteers
- 250 people
- Sponsor
- Assiut University
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water.
- Trial name
- DrinkAge (NCT07892742)
- Testing
- Water
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Polytechnic University of Santarém
Obesity, Overweight
Impact of Satiating Compounds and Hypocaloric Diet on Weight, Cardiometabolic and Osteoarticular Health in Obesity
The main objective of this intervention study is to evaluate the effect of satiating protein and/or fiber bar consumption on weight loss and other osteoarticular and cardiometabolic parameters related to excess weight in subjects…
- Trial name
- COGLUBOCO (NCT07165548)
- Testing
- Experimental Bar (Formulation 1) + Hypocaloric diet (10% energy restriction), Experimental Bar (Formulation 2) + Hypocaloric diet (10% energy restriction), Experimental Bar (Formulation 3) + Hypocaloric diet (10% energy restriction)
- Where
- Spain
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Shift-Work Related Sleep Disturbance, Metabolic Syndrome
Health Effect of Canola Oil Consumption in Shift Workers
Shift work is associated with a higher risk of the development of cardiometabolic syndrome (CMtS) than in people working only during the day.
- Conditions
- Shift-Work Related Sleep Disturbance, Metabolic Syndrome, Diet Modification, Work-Related Condition
- Trial name
- NCT03977558
- Testing
- Intervention group, Control group
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Cardiometabolic Risk Factors, Obesity, Abdominal
Powdered Fermented Fruits for Glycemia Reduction
The aim of the study is to evaluate the effects of an acute intake of two fermented fruits flours as part of a standardized breakfast, in comparison with the acute intake of a standardized breakfast without fermented fruits flour…
- Trial name
- P2F-GR (NCT04877548)
- Testing
- Fermented orange flour, Fermented grape flour, Control
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Childhood Obesity
Improving Cardiometabolic Health of Youth on Antipsychotic Medication
Pediatric antipsychotic treatment is associated with significant obesity-related side effects, including weight gain, increased blood sugar, abnormal cholesterol, and risk of new onset diabetes.
- Trial name
- NCT02877823
- Testing
- Treatment, Control
- Volunteers
- 302 people
- Sponsor
- University of Maryland, Baltimore
Obesity, Dental Care for Children
MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease
The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity.
- Trial name
- NCT07478653
- Testing
- Dental Cleaning and Oral Hygiene Instruction (OHI), Oral Hygiene Instruction (OHI)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oelisoa Andriankaja
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Hypertension (HTN), Cardiometabolic Diseases
Genetic Architecture of Natriuretic Peptides and Blood Pressure Response
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits.
- Trial name
- NCT07118592
- Testing
- Low Salt Diet, High Salt Diet, Saline Infusion
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Circadian Rhythm, Cardiometabolic Health
The Influence of Sleep on Cardiovascular Outcomes
The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and…
- Conditions
- Circadian Rhythm, Cardiometabolic Health, Vascular Health, Pain
- Trial name
- DISCO (NCT06535178)
- Testing
- Sleep Regularity Group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Metabolic Syndrome, Obesity
New Biomarkers for Predicting Systemic Complications in Obesity
This observational cross-sectional study classified participants into obesity classes (Class I: BMI 30.0-34.9, Class II: 35.0-39.9, Class III: ≥40.0 kg/m²) based on WHO criteria.
- Trial name
- NCT07260487
- Where
- Turkey (Türkiye)
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Cancer, Fatigue
MODERATE CONTINUOUS TRAINING VERSUS HIIT IN CANCER STADIUM II.
Introduction: Exercise programs focused on moderate intensity continuous training (MICT) and HIIT (High Intensity Interval Training) are shown as an effective treatment to mitigate the effects of cancer.
- Conditions
- Cancer, Fatigue, Sarcopenia
- Trial name
- NCT03915288
- Testing
- Group continuous training at moderate intensity, Group high Intensity Interval Training, Group control
- Volunteers
- 1,573 people
- Sponsor
- University Tolteca
Postpartum Weight Retention, Overweight and Obesity
Time-restricted Eating for Postpartum Weight Loss
This study is being done to assess the feasibility and acceptability of a time-restricted eating intervention among postpartum women with overweight/obesity.
- Trial name
- Time4Mom (NCT06491537)
- Testing
- Early Time-Restricted Eating (eTRE), Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Obesity & Overweight, Cardiometabolic Health Indicators
Tirzepatide Impact Assessment Study
This study examines how two different weight-loss strategies affect heart and metabolic health, as well as changes at the molecular level in the body.
- Conditions
- Obesity & Overweight, Cardiometabolic Health Indicators, Addiction, Eating Disorders
- Trial name
- TIA (NCT07740291)
- Testing
- GLP-1 Receptor Agonist Therapy, Structured Lifestyle Intervention
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Obesity, Cardiovascular Risk Factor
Exercise for Preventing the Metabolic Syndrome in Latinoamerican Amerindians
Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities.
- Conditions
- Obesity, Cardiovascular Risk Factor, Physical Activity
- Trial name
- NCT03653468
- Testing
- Concurrent training (CT)
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Metabolic Diseases, Overweight
Cardiometabolic HIIT-RT Study
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health such as body composition, endothelial function, blood pressure and blood lipids.
- Conditions
- Metabolic Diseases, Overweight, Motor Activity
- Trial name
- NCT02715063
- Testing
- High Intensity Interval, Resistance training, Plus: High Intensity Interval + Resistance Training
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Diabetes Mellitus, Chronic Kidney Diseases
Cardiometabolic Devices Accuracy Study
With the rise of cardiovascular diseases (CVD) and diabetes, the global disease burden is shifting towards non-communicable diseases (NCDs).
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Hyperlipidemias
- Trial name
- NCT05257564
- Testing
- Determine the accuracy of quantitative measurements of GLU, HbA1c,CHOL and CRE with POC devices compared to a laboratory reference method (Roche)
- Where
- Nepal
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Aging, Obesity & Overweight
Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock
This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2…
- Trial name
- NCT07444073
- Testing
- Not applicable. This is an observational study.
- Where
- 2 sites in Singapore
- Volunteers
- 440 people
- Sponsor
- National University of Singapore
Obesity, Inflammation
Inflammation and Obesity-associated Disease
Visceral obesity and adipose inflammation is considered a driving force of obesity-related systemic disease, e.g. cardiometabolic disease, liver cirrhosis and chronic kidney disease (CKD).
- Conditions
- Obesity, Inflammation, Kidney Disease, Liver Disease
- Trial name
- Adipos2 (NCT02322073)
- Testing
- Laparoscopic surgery
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Overweight, Obesity
The Effects of Quinoa and Buckwheat on Weight Management and Gut Microbiome
This study aims to compare the effects of quinoa, buckwheat, rice, and bulgur consumption on dietary intake, anthropometric measurements, glycemic response, lipid profile, inflammatory markers, blood pressure, and intestinal…
- Trial name
- NCT07513610
- Testing
- quinoa, Buckwheat, Rice
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hacettepe University