Clinical trials: Cardiometabolic Conditions
Obesity, Diabetes
Family Weight Management Study
The purpose of this study is to address the Healthy People 2010 obesity prevention objective. This study will test the effects of a comprehensive family weight management program on the BMI z-score of 7-12 year-old children with…
- Trial name
- NCT00851201
- Testing
- Intensive lifestyle, Standard intervention
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Type 2 Diabetes (T2D)
A Retrospective Real-World Cohort Study
The primary objectives are to determine the prevalence and overlap of major cardiometabolic diseases, identify multimorbidity clusters, and characterize demographic, clinical, laboratory, and treatment patterns across the cohort…
- Conditions
- Obesity, Type 2 Diabetes (T2D), Prediabetes, Cardiovascular Disease (CVD)
- Trial name
- SCALA-TK-CM (NCT07781371)
- Testing
- No treatment given
- Where
- Denmark
- Volunteers
- 100,000 people
- Sponsor
- Novo Nordisk A/S
Mitral Valve Insufficiency
Determinants of the Progression and Outcome of Mitral Regurgitation
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing with the aging of the population.
- Trial name
- PROGRAM (NCT01835054)
- Testing
- Blood biomarkers, DNA collection, Echocardiography
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 440 people
- Sponsor
- Laval University
HIV/AIDS, Lipohypertrophy
Effects of Semaglutide in HIV-Associated Lipohypertrophy
This is a randomized, double-blinded, placebo-controlled trial designed to assess the effect of the GLP-1 receptor agonist, semaglutide, on visceral and ectopic fat, insulin resistance, inflammation markers, and the downstream…
- Conditions
- HIV/AIDS, Lipohypertrophy, Obesity
- Trial name
- NCT04019197
- Testing
- Semaglutide Injectable Product
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Overweight and Obesity
Active Versus Passive Recovery During HIIT in Children With Overweight or Obesity
This study aims to evaluate the effects of a 12-week high-intensity interval training (HIIT) program with active versus passive recovery on physical performance, anthropometric characteristics, cardiometabolic parameters, and…
- Trial name
- NCT07861048
- Testing
- High-Intensity Interval Training with Active Recovery, High-Intensity Interval Training with Passive Recovery
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- High Institute of Sports and Physical Education of Kef
Diabetes Mellitus, Type 2, Myocardial Infarction
Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease
This is a 2x2 study examining the impacts of a novel exercise regimen and daily text message reminders in patients at high risk for cardiovascular disease.
- Conditions
- Diabetes Mellitus, Type 2, Myocardial Infarction, Coronary Artery Disease, Atrial Fibrillation
- Trial name
- BURST (NCT03103854)
- Testing
- BURST physical activity, Text Message Reminders, Moderate Intensity Continuous Training
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Cambridge Cardiac Care Centre
Obesity
Activation of Brain Centers by Short-term Walnut Consumption in Obesity
The purposes of the study are: Study Aim 1. To assess the mechanisms underlying the biological effects of short-term walnut consumption on appetite with functional magnetic resonance imaging (fMRI) and assessing neurocognitive…
- Trial name
- NCT02673281
- Testing
- Walnut shake
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
NAFLD, Liver Fibroses
Liver Damage and Cardiometabolic Disorders in NAFLD
Liver fibrosis is the most important prognostic factor in patients with non-alcoholic factor disease. Clinical and biological condition, as diabetes or mutation for PNPLA3, are well known factors associated with liver fibrosis…
- Conditions
- NAFLD, Liver Fibroses, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- PLINIO (NCT04036357)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- University of Roma La Sapienza
Obese, Overweight
The Effects of the GOLO for Life® Plan and Release Supplement on Weight Management in Overweight and Obese Adults
The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on weight loss, body composition, and cardiometabolic parameters in overweight and obese adults.
- Trial name
- NCT05844631
- Testing
- Release
- Where
- 2 sites in Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Golo
Polycystic Ovary Syndrome, Obesity, Metabolic
Krill Oil and Metformin in Women With PCOS and Metabolically Unhealthy Obesity
This open-label, randomized, parallel-group pilot trial investigated the effects of krill oil, metformin, and their combination on adipokine profiles, cardiometabolic risk markers, and serum fatty acid composition in women with…
- Trial name
- NCT07604870
- Testing
- Metformin Hydrochloride 1000 MG, Krill Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Firat University
PreDiabetes, Abdominal Obesity
Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus
This multicenter, double-blinded, randomized controlled trial aims to evaluate the effect of berberine on preventing cardiovascular disease and diabetes mellitus among individuals with high cardiometabolic risk in China.
- Conditions
- PreDiabetes, Abdominal Obesity, Hypertension, Dyslipidemias
- Trial name
- ABCD (NCT05749874)
- Testing
- Berberine plus lifestyle intervention
- Where
- China
- Volunteers
- 2,024 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obesity, Gastric Bypass
Impact of a Specific Micronutrient-probiotic-supplement on Fatty Liver of Patients After Mini-Gastric Bypass Surgery
Aim of this prospective randomized intervention study is to evaluate the effect of a dietary intervention with a specific micronutrient-probiotic-combination for 12 weeks on fatty liver and cardiometabolic status in obese…
- Conditions
- Obesity, Gastric Bypass, NAFLD
- Trial name
- FMG-01 (NCT03585413)
- Testing
- Micronutrient-probiotic-combination
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Bonn Education Association for Dietetics r.A., Cologne, Germany
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
Obesity & Overweight
Effect of an Eight Week Dietary Intervention of Pecans on Cardiometabolic Parameters and Serum Cytokines in Individuals With Obesity or Overweight
You are invited to participate in a research study being conducted by Karen Gibson, Maria Morgan-Bathke, Dana Swope, Grace Huebner, Rebecca Brannan, Samuel McCormick at Viterbo University.
- Trial name
- NCT07732816
- Testing
- Pecan Intervention
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Viterbo University
Obesity
Effects of Exercise Training in Individuals Undergoing Bariatric Surgery
The subject of the research; Effects of exercise training on cardiometabolic risk factors and functional capacity in individuals undergoing bariatric surgery.
- Trial name
- NCT05085015
- Testing
- Functional Exercise Training Group, Home Exercise Training Group
- Where
- Cyprus
- Volunteers
- 64 people
- Sponsor
- Eastern Mediterranean University
Cardiovascular Disease
the Canadian Health Improvement Network to Upgrade Prevention Services
RATIONALE Controlling cardiovascular risk factors has been proven to be effective in prevention and management of cardiovascular disease (CVD).
- Trial name
- CHIN-UPS (NCT02310685)
- Testing
- Comprehensive e-health wellness program
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- McGill University
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
The purpose of this study is to learn more about how the body stores fat in and around organs (for example in the liver) and why this affects some people's health more than others.
- Conditions
- Non-alcoholic Fatty Liver Disease, Metabolic Syndrome, Metabolically Abnormal Obesity, Metabolically Normal Obesity
- Trial name
- NCT01104220
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Physical Performance Parameters, Exercise Recovery
Effects of Beef-Forward Ready-to-Eat Meals on Recovery Following Simulated Fire Suppression Activities
This clinical trial aims to determine whether consuming beef-based protein before and after physically demanding simulated firefighting activities improves recovery, physical performance, and cognitive performance in healthy…
- Conditions
- Physical Performance Parameters, Exercise Recovery, Cognition, Muscle Damage
- Trial name
- FIRE-BEEF (NCT07822048)
- Testing
- Beef-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Obesity
Safety and Tolerance of a Nutritional Intervention Program- In.Form 1.2
The study evaluated and the safety, tolerance and acceptability of a lifestyle modification program with nutritional supplementation in generally healthy overweight subjects with cardiometabolic risk factors.
- Trial name
- NCT03098056
- Testing
- PROG2
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nature's Sunshine Products, Inc.
Elevated Blood Glucose
Whole-Food Magnesium for Mental and Cardiometabolic Health
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of daily supplementation with E-Z Mg™, a commercially available whole-food-based magnesium supplement, on sleep, mood, fatigue, and…
- Trial name
- NCT07865351
- Testing
- Low-Dose Whole-Food-Based Magnesium Supplement, Moderate-Dose Whole-Food-Based Magnesium Supplement
- Volunteers
- 45 people
- Sponsor
- George Mason University