Clinical trials: Cardiometabolic Health
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Psychological Distress, Cardiometabolic Syndrome
Shift-and-persist and Cardiometabolic Markers Among Women in Puerto Rico
The goal of this clinical trial is to evaluate the feasibility and acceptability of a 4-week mindfulness program among young women in Puerto Rico with elevated stress.
- Trial name
- NCT06250738
- Testing
- Mindfulness-based Stress reduction program: Virtual, Home exercises
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emory University
Cardiometabolic Health Indicators
Behavioral Economic Attributes of Recreation
Risk for developing and dying from heart disease, type 2 diabetes, stroke, and other cardiometabolic conditions is strongly influenced by behavioral risk factors, including poor diet, physical inactivity, and tobacco and alcohol…
- Trial name
- BEAR (NCT07282418)
- Testing
- Recreation Enhancement
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Adiposity, Insulin Sensitivity
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners…
- Conditions
- Adiposity, Insulin Sensitivity, Weight Gain, Blood Pressure
- Trial name
- NCT05992688
- Testing
- Sucrose sweetened beverage, Stevia sweetened beverages, Calorie free flavored water beverage
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Inflammation, Obesity
Inflammatory Resolution in Cardiometabolic Health and Disease
The specific aim of this study is to determine molecular pathways that differentiate metabolically healthy vs unhealthy human phenotypes, and to investigate the therapeutic potential of pro-resolving lipids.
- Conditions
- Inflammation, Obesity, Cardiovascular Diseases
- Trial name
- RESOLVE AU (NCT06390189)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Arterial Stiffness, Blood Pressure
Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women
The goal of this clinical trial is to assess the impact of table grape consumption on gut microbiome, intestinal permeability, systemic inflammation, and vascular function in healthy overweight men and women aged 45-70 years.
- Conditions
- Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation
- Trial name
- CALGRAM (NCT06544954)
- Testing
- Freeze-dried grape powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
PreDiabetes, Obesity
WorkWell: Work-based Activity and Metabolic Health
This study will test whether a range of pre-clinical cardiometabolic biomarkers can be improved via regular intervals of standing and light-intensity physical activity in real-world office environments.
- Trial name
- NCT04269070
- Testing
- Standing condition, Light physical activity (LPA) condition, Usual behavior condition
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Metabolic Diseases, Overweight
Cardiometabolic HIIT-RT Study
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health such as body composition, endothelial function, blood pressure and blood lipids.
- Conditions
- Metabolic Diseases, Overweight, Motor Activity
- Trial name
- NCT02715063
- Testing
- High Intensity Interval, Resistance training, Plus: High Intensity Interval + Resistance Training
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Cardiometabolic Health
How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses
The goal of this clinical trial is to learn how different protein types affect the body's metabolism and immune system in healthy adults.
- Trial name
- NCT07121010
- Testing
- Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diet Intervention
Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome
This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.
- Trial name
- NCT06433115
- Testing
- Lean (≥90%) Grass-Fed Beef, Lean (≥90%) Grain-Fed Beef, Plant-Based Meat
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Ramadan Fasting, Obesity & Overweight
Effects of Ramadan Fasting With Exercise on Cardiometabolic Health
The goal of this interventional study is to examine the effects of Ramadan diurnal fasting alone and in combination with moderate-intensity aerobic exercise on cardiometabolic health in adults with overweight and obesity.
- Conditions
- Ramadan Fasting, Obesity & Overweight, Aerobic Exercise, Weight Loss
- Trial name
- NCT07471646
- Testing
- Moderate-Intensity Aerobic Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiometabolic Risk Factors
Dissecting the Roles of High-quality Diets and Ultra Processed Foods on Cardiometabolic Health
Controversy remains around the role of ultra-processed food (UPF) consumption and health outcomes. A key question that remains to be answered is: when diet quality is the same, does food processing itself have any independent…
- Trial name
- NCT06749327
- Testing
- High UPF, high hPDI diet, Low UPF, high hPDI diet
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Sedentary Lifestyle
Healthy Aging Resources to Thrive (HART)
Healthy Aging Resources to Thrive (HART) uses a rigorous two-stage randomized control design, adapted and refined based on pilot studies, to test a novel intervention to reduce sitting time in older adults.
- Trial name
- HART (NCT03739762)
- Testing
- i-STAND, Healthy Living control
- Where
- United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity
Using Grassroots Wellness Coaching to Enhance Reach and Sustainability of Behavioral Weight Management
African American adults that live in economically disadvantaged areas are at an increased risk for obesity and cardiometabolic disease.
- Trial name
- NCT05544708
- Testing
- Wellness Engagement Intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cardiovascular Diseases, Obesity, Visceral
Extreme Exercise and Energy Expenditure (4E) Study
The goal of this clinical trial is to provide evidence, through an extreme exercise prescription (1,144 km of road cycling on seven consecutive days), that weight loss is not the appropriate outcome to evaluate the effects of…
- Conditions
- Cardiovascular Diseases, Obesity, Visceral, Liver Fat, Metabolic Syndrome
- Trial name
- NCT05895916
- Testing
- High-volume road cycling
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Blood Pressure, Body Composition, Immune Function
Evaluating the Effects of a Synbiotic Versus Probiotic or Placebo on Gut Microbiota and Cardiometabolic Health: A Randomized Double-Blind Placebo Controlled Trial
Accordingly, the purpose of this study is to evaluate the efficacy of 1) supplementation with Synbiotic (Plexus® Triplex), 2) commercially-available Probiotic, or 3) placebo control over 30 days on the gut microbiome…
- Trial name
- GUTRCT (NCT06544915)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Vegan Diet, Body Composition
Acute Metabolic Response Versus Long-term Adaptation to a Vegan Diet
At baseline, venous blood samples were collected from all eligible participants. The following biochemical parameters were analysed: serum electrolytes (mineral profile), fasting glucose, creatinine, urea nitrogen, total…
- Conditions
- Vegan Diet, Body Composition, Quality of Life (QOL), Cardiometabolic Health
- Trial name
- VITAL (NCT07731633)
- Testing
- vegan diet
- Where
- Slovakia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Supplementation in Healthy Adults to Assess Impact on Omega 3 Index and Cardiometabolic Health
Change in Omega 3 Index in Healthy Adults With OmeGo or a Standard Omega-3 Oil Supplement
Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits of eating fresh fish.
- Trial name
- NCT06802068
- Testing
- whole salmon oil, Cod liver oil
- Where
- 2 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA