Clinical trials: Cardiomyopathies
Cardiomyopathies, Truncation Mutation
Moderate Intensity Training in Patients With Truncating Genetic Variants in TTN.
The aim is to investigate the effect of an 8-week moderate-intensity exercise program on aerobic fitness and cardiac contractility in patients with truncations of the sarcomeric protein titin.
- Conditions
- Cardiomyopathies, Truncation Mutation, TTN
- Trial name
- NCT05180188
- Testing
- Training
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Congestive
FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.
The purpose of this study is to assess the safety and tolerability of two doses of nesiritide (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) when administered…
- Trial name
- NCT00270361
- Testing
- nesiritide, usual long term cardiac medications
- Volunteers
- 214 people
- Sponsor
- Scios, Inc.
ISCHEMIC CARDIOMYOPATHY
Efficacy of EVP 1001-1 (SeeMore) in the Assessment of Myocardial Viability in Patients With Cardiovascular Disease
The investigator hopes to introduce a novel MRI contrast agent with SeeMore ™ that directly defines viable myocardium. Identifying viable myocardium non-invasively using cardiac MRI is still a moving target and a question we plan…
- Trial name
- NCT01989195
- Testing
- 'SEEMORE' - MANGANESE-ENHANCED MRI CONTRAST REAGENT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Pacing-Induced Cardiomyopathy
Effect of Leadless Pacing on Heart Function
This prospective, un-blinded, randomized, noninferiority, single centre study with 12 month follow-up included patients who were scheduled for a single-chamber PM implant.
- Trial name
- NCT06100757
- Testing
- Micra Transcatheter Pacing System (TPS°, Conventional pacemaker type Medtronic Advisa ADSR03 or Azure XT VR
- Where
- Belgium
- Volunteers
- 51 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cardiomyopathies, Pediatric ALL
Ventricular Remodelling and Metabolomics in Pediatric Cardiomyopathies (PROGRESS-OMICS)
The pathogenesis of cardiomyopathies is complex and a simple approach cannot describe the whole picture. Different etiologies are reported in pediatric age and heart failure onset can lead to poor prognosis in term of need of…
- Trial name
- PRO-OMICS (NCT04670731)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Ranolazine Implantable Cardioverter-Defibrillator Trial
The purpose of the study is to see how effective a drug called ranolazine is in reducing the risk of ventricular arrhythmia and death in people with implantable cardioverter-defibrillators (ICDs).
- Conditions
- Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- RAID (NCT01215253)
- Testing
- Ranolazine
- Where
- 90 sites in United States, Canada
- Volunteers
- 1,012 people
- Sponsor
- University of Rochester
Dilated Cardiomyopathy
The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy
Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM). Its presence is believed to increase the risk of malignant ventricular arrhythmias (VA), but the mechanism of…
- Trial name
- DCM-MSF (NCT05026112)
- Testing
- ECG-Imaging, Cardiac MRI scan
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Myocarditis, Cardiomyopathies
Clinical Study of Endocardial Myocardial Biopsy
In this study, patients with endocardial myocardial biopsy were selected to observe the safety of the operation, and pathological examination was performed.
- Conditions
- Myocarditis, Cardiomyopathies, Heart Failure, Cardiac Tumor
- Trial name
- NCT05718128
- Testing
- Endocardiomyocardial biopsy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Arrhythmogenic Cardiomyopathy
Risk Stratification, Early Prevention and Treatment Strategies for Arrhythmogenic Cardiomyopathy
This study will include patients diagnosed with Arrhythmogenic cardiomyopathy (ACM) in the First Affiliated Hospital of Xi 'an Jiaotong University and other centers, and collect clinical data and biological samples of patients…
- Trial name
- STARTER (NCT06352307)
- Testing
- Diagnosis of ACM
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cardiomyopathies
Contrast Echocardiography Cost Effectiveness for Left Ventricular Thrombus Assessment
To perform a cost-effectiveness analysis for the routine use of contrast in rest echocardiography in patients with dilated or ischemic cardiomyopathy from the United States healthcare system, provider and payer perspectives.
- Trial name
- NCT02555527
- Where
- United States
- Volunteers
- 500,000 people
- Sponsor
- Duke University
Ischemic and Nonischemic Cardiomyopathy, With Primary and Secondary Implant Indications
A Study Comparing the Sensed R Wave in Bipolar and Extended Bipolar Configurations
The PropR study will evaluate sensing during ventricular fibrillation (VF) in both bipolar and extended bipolar configurations, in order to evaluate if both can be used interchangeably in caring for patients.
- Trial name
- PropR (NCT01032577)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Trinity Health Of New England
Cardiomyopathy
T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease
Diffuse fibrosis (or scarring) of the heart muscle is found in a variety of congenital heart diseases and in cardiomyopathies (heart muscle disease), and is considered a mediator of decreased cardiac function.
- Trial name
- NCT02350829
- Testing
- Cardiac magnetic resonance sequence T1 mapping
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Autonomic Nervous System Disease, Amyloid Neuropathies
Autonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart Disease
Transthyretin amyloidosis exhibits a variety of possible phenotypes, the hereditary neurological form being the most commonly found and studied (familial amyloidotic polyneuropathy or FAP), which can present from oligosymptomatic…
- Trial name
- NCT05087953
- Testing
- Head-Up Tilt table test, Heart Rate Variability
- Where
- 3 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiomyopathy
Observational Epidemiological Study of Patients Suffering From Systemic Amyloidosis
observational epidemiological study of patients affected by systemic amyloidosis
- Trial name
- AMI-ER (NCT06866912)
- Where
- Italy
- Volunteers
- 750 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Subarachnoid Hemorrhage, Myocardial Stunning
Serial Echocardiography After Subarachnoid Hemorrhage
There is increasing interest in myocardial abnormalities following central nervous system events, such as subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Myocardial Stunning, Takotsubo Cardiomyopathy
- Trial name
- SEAS (NCT00123695)
- Where
- 6 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Amsterdam UMC, location VUmc
Non-ischemic Cardiomyopathy
Sudden Death Stratification
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related.
- Trial name
- NCT04607265
- Testing
- Cardiac MRI
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Valvular Heart Disease, Pericardial Disease
PPG to Predict Ejection Fraction and Other Echographic Data in the General Population
The investigators are aiming to investigate the association between ejection fraction (EF) determined by echocardiography and signals obtained from Photoplethysmography (PPG) in the general population.
- Conditions
- Valvular Heart Disease, Pericardial Disease, Cardiomyopathies
- Trial name
- NCT04843371
- Testing
- Photoplethysmography
- Where
- 3 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tulane University
Dilated Cardiomyopathy, Heart Failure
Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM)
The goal of REMEDIUM project is to develop personalized stem cell therapy for patients with chronic heart failure due to dilated cardiomyopathy (DCM).
- Trial name
- REMEDIUM (NCT02248532)
- Testing
- Stem cell therapy
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Chemotherapy Effect
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors
Early detection of cardiomyopathy in patients receiving Anthracycline chemotherapy and determine if speckle tracking echo and Troponin gene will add benefit for early detection of cardiomyopathy.
- Trial name
- NCT03381014
- Testing
- Chemotherapy, Cancer, Anthracyclines
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiac Rehabilitation
"Cardiac Rehabilitation in Patients With Hypertrophic Cardiomyopathy".
Hypertrophic cardiomyopathy (HCM) is the most common hereditary disease characterized by left ventricular hypertrophy and consequently left ventricular diastolic dysfunction.
- Trial name
- NCT03178357
- Testing
- Cardiac rehabilitation + standard therapy, Standard therapy
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland