Clinical trials: Cardiomyopathy, Congestive
Mitral Valve Insufficiency, Heart Failure
Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
Mitral regurgitation (MR), also known as mitral insufficiency, is a condition in which the heart's mitral valve, located between two of the heart's main chambers, does not firmly shut, allowing blood to leak backwards within the…
- Trial name
- SMMART-HF (NCT00608140)
- Testing
- Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
- Where
- 9 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Duke University
Dilated Cardiomyopathy, Heart Failure
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
This is a prospective, single-arm clinical trial in which participants with dilated cardiomyopathy will invite their first degree relatives to undergo mobile cardiac, electrocardiogram screening.
- Conditions
- Dilated Cardiomyopathy, Heart Failure, Heart Disease
- Trial name
- DCM-DETECT (NCT06688396)
- Testing
- Mobile 6L AI-EKG Screening
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Heart Failure, Congestive, Dilated Cardiomyopathy
Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
The study is divided into 2 parts. In the first part, the safety of the gene transfer agent MYDICAR® will be evaluated. In the second part, the ability of MYDICAR® to improve heart function will be studied.
- Trial name
- CUPID (NCT00454818)
- Testing
- MYDICAR Phase 1 (Open-label, Serial Dose-Escalation Study)
- Where
- 22 sites in United States
- Volunteers
- 51 people
- Sponsor
- Celladon Corporation
Dilated Cardiomyopathy
Examining the Effects of Mitochondrial Oxidative Stress in DCM
Double blind, randomised, placebo-controlled trial of MitoQ (mitoquinol mesylate) in 106 patients with dilated cardiomyopathy, examining the effect of reducing mitochondrial oxidative stress on myocardial energetics and…
- Trial name
- MitoDCM (NCT05410873)
- Testing
- MitoQ Compound
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Imperial College London
Left Bundle-Branch Block, Heart Failure
Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT) is an effective therapeutic strategy in patients with symptomatic heart failure (HF) patients with LVEF of ≤35% and left bundle branch block (LBBB).
- Conditions
- Left Bundle-Branch Block, Heart Failure, Cardiac Resynchronization Therapy, Dilated Cardiomyopathy
- Trial name
- FLOW-LBBB (NCT05564689)
- Testing
- Intracoronary flow and pressure
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Ashkan Eftekhari
Heart Failure，Congestive, Cardiomyopathies
HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy
This is a randomized, prospective, single-blinded trial to determine the overall rate of successful His-Purkinje conduction system pacing Optimized Trial of Cardiac Resynchronization Therapy (HOT-CRT) versus biventricular pacing…
- Conditions
- Heart Failure，Congestive, Cardiomyopathies, Left Ventricular Dysfunction
- Trial name
- HOT-CRT (NCT04561778)
- Testing
- HOT-CRT, Biventricular Pacing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pugazhendhi Vijayaraman
Dilated Cardiomyopathy
Nesiritide - Dilated Cardiomyopathy
Nesiritide is a rapid vasodilator that mimics the action of an endogenous hormone - human B-type natriuretic peptide (BNP). BNP is produced naturally in the ventricles of the heart in response to stretch.
- Trial name
- NCT00709163
- Testing
- Nesiritide, 5% Dextrose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Chronic Heart Failure, Ischemic Heart Disease
Echo Assessment of Intraventricular Dyssynchrony
Background. Clinical benefits of cardiac resynchronization therapy (CRT) have been clearly demonstrated in heart failure (HF) patients with severe left ventricular (LV) dysfunction and wide QRS at surface electrocardiogram.
- Conditions
- Chronic Heart Failure, Ischemic Heart Disease, Dilated Cardiomyopathy
- Trial name
- IMPROVE (NCT00646243)
- Where
- Italy
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Italian Society of Cardiology
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Non-ischemic Dilated Cardiomyopathy
Study of Personalized Allocation of Defibrillators in Non-ischemic Heart Failure (SPANISH-1)
Prospective, randomised, multicentre, open-label study to assess the non-inferiority of a personalised precision strategy for Sudden Cardiac Death (SCD) prevention in patients with non-ischemic dilated cardiomyopathy with Left…
- Trial name
- NCT06055504
- Testing
- Control Strategy, Personalized precision ICD implantation Strategy based in genetic findings and CMR results
- Where
- 31 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Congestive Heart Failure, Ischemic Cardiomyopathy
AutoLogous Human CArdiac-Derived Stem Cell to Treat Ischemic cArdiomyopathy (ALCADIA)
The aim of this study is to evaluate the safety and efficacy on the transplantation of autologous human cardiac-derived stem cells (hCSCs) with the controlled release of basic fibroblast growth factor (bFGF) to severe refractory…
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Ventricular Dysfunction
- Trial name
- ALCADIA (NCT00981006)
- Testing
- human cardiac stem cells
- Where
- 2 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Naofumi Takehara
Dilated Cardiomyopathy (DCM)
Protein A Immunoadsorption in Dilated Cardiomyopathy (RPIA-DCM)
This study is a multicenter, dual-arm and randomized controlled clinical trial. Sixty patients with dilated cardiomyopathy and positive β1-adrenergic receptor autoantibodies were selected and randomly divided into an…
- Trial name
- NCT06922851
- Testing
- Immunoadsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypertrophic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve
The aim of this study is to assess microvascular function as determined by a cardiovascular magnetic resonance measurement of whole-heart (global) perfusion reserve.
- Conditions
- Hypertrophic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy, Microvascular Ischaemia of Myocardium
- Trial name
- NCT03249272
- Testing
- Regadenoson, Adenosine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Breast Carcinoma, Cardiomyopathy
TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer
This study examines TRPC6 in predicting and preventing chemotherapy related cardiac toxicity and heart failure in patients with breast cancer.
- Conditions
- Breast Carcinoma, Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT05507879
- Testing
- Biospecimen Collection, Electronic Medical Record
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Chronic Ischemic Heart Disease, Left Ventricular Dysfunction
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)
Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments.
- Conditions
- Chronic Ischemic Heart Disease, Left Ventricular Dysfunction, Angina, Ischemic Cardiomyopathy
- Trial name
- NCT00824005
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiomyopathy, Dilated
Autologous Stem Cells in Pediatric Patients With Dilated Cardiomyopathy
The purpose of this study is to determine whether an autologous stem cell infusion through catheterism is safe and effective in the treatment of pediatric dilated cardiomyopathy. Process: 1.
- Trial name
- NCT01504594
- Testing
- Intracoronary autologous stem cell infusion
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Ischemic Congestive Heart Failure (CHF)
Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure
The purpose of this study is to evaluate the safety and bioactivity of intramyocardial gene transfer using VEGF (vascular endothelial growth factor) in patients with ischemic heart failure.
- Trial name
- NCT00279539
- Testing
- Vascular Endothelial Growth Factor (VEGF1)
- Sponsor
- Losordo, Douglas, M.D.
Breast Cancer
BrUOG 291: Five Fraction Partial Breast Irradiation Using Non-invasive Image-guided Breast Brachytherapy (NIBB)
To evaluate safety of 5 fraction accelerated partial brest irradiation in more convenient 5 fraction schedule.
- Trial name
- NCT01961531
- Testing
- Accuboost APBI
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Left Ventricular Systolic Dysfunction, Congestive Heart Failure
SCD-HeFT 10 Year Follow-up
No clinical trial that has examined the role of implantable cardioverter defibrillator (ICD) therapy in the prevention of Sudden Cardiac Death (SCD) has provided outcome data for longer than a few years.
- Conditions
- Left Ventricular Systolic Dysfunction, Congestive Heart Failure, Ischemic and Non-ischemic Cardiomyopathy, Sudden Cardiac Death Primary Prevention
- Trial name
- SCD-HeFT10 Yr (NCT01058837)
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- Seattle Institute for Cardiac Research