Clinical trials: Cardiomyopathy
Athlete Heart
Prospective Athlete's Heart Study
The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e.
- Trial name
- Pro@Heart (NCT05164328)
- Testing
- No intervention
- Where
- 4 sites in Australia, Belgium
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Peripartum Cardiomyopathy
Creation of a Multicenter National Registry for Peripartum Cardiomyopathy.
Peripartum cardiomyopathy (PPCM) is a rare, severe and potentially life-threatening disorder of largely unknown etiology and pathophysiology, with unexplained geographical differences and heterogeneous presentation.
- Trial name
- PPCMREGISTRY (NCT05878041)
- Testing
- Molecular and genetic screening
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Duchenne Muscular Dystrophy
Wearable Technology to Evaluate Hyperglycemia and HRV in DMD
Duchenne muscular dystrophy (DMD) is an X-linked disorder that causes muscle wasting, cardiopulmonary failure, and premature death.
- Trial name
- NCT06124196
- Testing
- wearable technology
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
The MedSeq™ Project seeks to explore the impact of incorporating information from a patient's whole genome sequence into the practice of clinical medicine.
- Trial name
- NCT01736566
- Testing
- Family History + Whole Genome Sequencing, Family History Only
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Covid19, Cardiac Disease
COvid-19 LongitUdinal Multiethnic BioImaging Assessment of CARDiovascular Sequelae Registry
COLUMBIA CARDS is a pilot study to understand how COVID-19 affects the heart. It is known that COVID-19 can affect the heart in different ways.
- Conditions
- Covid19, Cardiac Disease, Cardiac Arrhythmia, Myocarditis
- Trial name
- NCT04661657
- Testing
- Transthoracic echocardiogram (TTE), Cardiovascular Magnetic Resonance (CMR) Imaging
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardiomyopathy, Familial
Modeling and Pharmacological Targeting of Genetic Cardiomyopathy in Children Via Cardiomyocytes Derived From Induced Pluripotent Stem Cells (DMDstem)
Interventional, cross-sectional biomedical study of children with genetic cardiomyopathy and healthy children. The aim is to generate, via induced human pluripotent stem cells (hiPSC), "patient-specific" cardiomyocytes (CMs)…
- Trial name
- DMDstem (NCT03696628)
- Testing
- Electrocardiogram, physical examination, echocardiography
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
Individualized Early Risk Assessment for Heart Diseases
Heart failure (HF) is the common end-stage of different medical conditions. It is the only growing cardiovascular disease and its prognosis remains worse than that of many malignancies.
- Trial name
- IndivuHeart (NCT02417311)
- Testing
- Skin biopsy, genotyping and disease phenotyping
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertrophic Cardiomyopathy, Hearing Loss
Refining Information Technology Support for Genetics in Medicine
The clinical use of genetic testing is expanding and, as a result, the number of variants identified in patients is growing. Knowledge of the clinical impact of these variants improves over time.
- Conditions
- Hypertrophic Cardiomyopathy, Hearing Loss, Cancer
- Trial name
- RISGIM (NCT01225978)
- Testing
- GeneInsight Clinic (GIC)
- Where
- 9 sites in United States, Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Long QT Syndrome, Brugada Syndrome
Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome…
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- QUALIMYORYTHM (NCT04712136)
- Testing
- MRI
- Where
- France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cardiomyopathy
A Phase I Trial on the Relative Bioavailability and Food Effect of HRS-1893 Tablets in Healthy Subjects
This Phase I clinical trial will investigate the relative bioavailability between two formulations of HRS-1893 tablets and the influence of food on the drug's pharmacokinetics in healthy adult participants.
- Trial name
- NCT07272330
- Testing
- HRS-1893 tablet A, HRS-1893 tablet B
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
SARS-CoV-2 Positive Patients
Follow-up Study of COVID-19 Patients in the District Konstanz
This is a prospective single-center study for the follow-up of SARS-CoV-2 positive patients in the district of Konstanz (LKN). As part of the coronavirus pandemic, patients with SARS-CoV-2 infection are currently being treated in…
- Trial name
- FSC19-KN (NCT04724434)
- Where
- Germany
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Hegau-Bodensee-Klinikum Singen
Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies
Mayo AVC Registry and Biobank
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT03049254
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiomyopathies, Insulin Resistance
Early MRI Detection of Myocardial Deterioration as a Preventive, Disease Staging, and Prognostic Biomarker in Insulin Resistance
The purpose of this study is to evaluate the relationship between insulin resistance (IR) and myocardial tissue abnormalities. The study will focus on a patient population, South Asians, with a high prevalence of IR.
- Conditions
- Cardiomyopathies, Insulin Resistance, Non-ischemic Cardiomyopathy, Cardiac Fibrosis
- Trial name
- NCT03509441
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Stanford University
Myocarditis
Incidence, Patient Characteristics and Outcome of Myocarditis After COVID-19 mRNA Vaccine
This study evaluates the incidence, patient characteristics and outcome of myocarditis after the COVID-19 mRNA vaccination in healthcare professionals.
- Trial name
- MACIS (NCT05438472)
- Testing
- data collection in healthcare professionals with COVID-19 mRNA vaccine booster
- Where
- Switzerland
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cardiomyopathy
A Bioequivalence Study of Two Formulations of HRS-1893 Tablets in Healthy Participants
This study will investigate the bioequivalence between two formulations of HRS-1893 tablets. Safety and tolerability will also be assessed.
- Trial name
- NCT07479641
- Testing
- Test formulation of HRS-1893 tablet, Reference formulation of HRS-1893 tablet
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Liver Cirrhosis, Cirrhotic Cardiomyopathy
Prevalence, Clinical Features and Risk Factors of Cirrhotic Cardiomyopathy Assessed by Two-dimensional Speckle Tracking Imaging
The purpose of this study is to assess the prevalence of cirrhotic cardiomyopathy in patients with cirrhosis, and to analyze the correlation between the severity of cirrhosis and cardiac dysfunction.
- Trial name
- NCT04969055
- Testing
- Not
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Chagas Cardiomyopathy
Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
- Trial name
- NCT03524768
- Testing
- skin laser speckle contrast imaging and video-capillaroscopy
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Myocarditis, Heart Failure
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR).
- Conditions
- Myocarditis, Heart Failure, Myocardial Fibrosis, Vascular Inflammation
- Trial name
- IMPReSSION (NCT04444128)
- Testing
- Cardiac Imaging
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cardiomyopathy
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue.
- Trial name
- NCT01856400
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cardiomyopathy
Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.
- Trial name
- NCT01048125
- Testing
- Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia