Clinical trials: Cardiopulmonary Bypass Surgery
Lung Ultrasound
Ultrasonographic Assessment of the Effect of CPB Acute Lung Injury
The study is designed to use the lung ultrasound to assess the effect of intermittent lung recruitment during cardiopulmonary bypass in cardiac surgeries on extra vascular lung water.
- Trial name
- CBP (NCT03619525)
- Testing
- lung recruitment
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ischemic Heart Disease
Oral Glutamine in Cardiopulmonary Bypass
Introduction: Glutamine (GLN) is the most abundant free amino acid in the body. It modulates immune cell function and is an important energy substrate for most cells (especially for enterocytes and lymphocytes) in critical…
- Trial name
- NCT02491931
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Kidney Injury
Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery
The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene…
- Trial name
- NCT05871203
- Testing
- Gene sequencing
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sepsis, Cardiopulmonary Bypass
Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass
Using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing CPB were explored.
- Trial name
- CPB-MUL-GM (NCT04032938)
- Testing
- extracorporeal circulation during cardiac surgery
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coronary Artery Disease
Efficacy of Early Short-term Training on Thrombogenesis in Patients Following Coronary Bypass Surgery
Although the benefit of cardiac rehabilitation following coronary artery bypass graft (CABG) is well-established, it is underused.
- Trial name
- NCT02144480
- Testing
- Intensive training, traditional training
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Cardiovascular Surgery, Blood Loss, Surgical
Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil
Randomized trial to evaluate the effectiveness of a intra operative blood recovery system in reducing the need for allogeneic transfusion in cardiovascular surgeries using cardiopulmonary bypass
- Trial name
- NCT06601582
- Testing
- Use of a operative blood salvage system
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Coagulopathy, Cardiac Surgery, Cardiopulmonary Bypass
Coagulopathy in Cardiac Surgery
Coagulopathy in cardiac surgery; a quaternary-care academic center experience Objectives: Primary: To determine incidence of coagulopathy after cardiac surgery in Thai people To determine incidence of resternotomy for stop…
- Trial name
- NCT03475940
- Where
- 2 sites in Thailand
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Nursing Safety on Cardiopulmonary Bypass
Assessment of Intraoperative Nursing Safety Precautions for Open Heart Surgery Patients on Cardiopulmonary Bypass Machine
Assessment of intraoperative nursing safety precautions for open heart surgery patients on cardiopulmonary bypass machine.
- Trial name
- NCT05494372
- Testing
- safety precautions
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vasodilatory Hypotension During or After Cardiac Surgery
ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
The purpose of this research is to evaluate the use of Angiotensin II in patients with low blood pressure post-surgery. Your information will be collected for 28 days post the procedure and initiation of the study drug to assess…
- Trial name
- NCT06487585
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland St. Joseph Medical Center
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Right Heart Failure, Right Ventricular Dysfunction
Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
In cardiac surgery, the presence of pulmonary hypertension (PH) is a prognostic factor associated with increased mortality and morbidity.
- Trial name
- MILAN (NCT05450328)
- Testing
- Combined Epoprostenol Sodium & Milrinone, Normal saline
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Cardiac Valve Disease
Ultrafiltration on Coagulation Function in Cardiac Surgery
To determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (CPB), on coagulation profile in patients undergoing cardiac surgery
- Trial name
- NCT04031144
- Testing
- Ultrafiltration
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Heart Valve Diseases, Image
Research on Neurological Prognosis of Patients Undergoing Heart Valve Surgery
The purpose of this study is to clarify the changes of neurocognitive function of patients undergoing cardiac valve disease before and after surgical treatment under cardiopulmonary bypass operation, and to predict the…
- Trial name
- NCT05539261
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier