Clinical trials: Cardiopulmonary Disease
Sickle Cell Anemia
Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
The purpose of this study is to use comprehensive exercise testing to examine longitudinal changes in exercise capacity over a 2 year period in children and young adults with sickle cell anemia.
- Trial name
- NCT01558076
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Healthy Volunteers
Impact of Different Face Masks on Maximal and Submaximal Performance Testing During COVID-19
In COVID 19, masks wearability has become a new normal and this "new normal" presented evidence-based performance limitations. The study findings are aimed to objectify parametric changes (if any) and therefore, will assist in…
- Trial name
- NCT05150613
- Testing
- No Mask, Surgical Mask, N95 Mask
- Where
- 2 sites in Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cardio Respiratory Arrest
Effectiveness of a Network of Trained Volunteers Automatically Activated, on the Reduction of the Start Time of Cardiopulmonary Resuscitation Maneuvers. Study Protocol.
Background Cardiorespiratory arrest (CRA) is a health emergency with high mortality. Mortality could depends on the start time of cardiopulmonary resuscitation (CPR) maneuvers (and the quality of its performance) and the use of…
- Trial name
- Smartwatch (NCT03828305)
- Testing
- Training and creation of the Network-CPR, Control Group
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Cardiac Valve Disease
Ultrafiltration on Coagulation Performance in Cardiac Surgery
In cardiac surgery patients with CPB-induced dilutional coagulopathy, ultrafiltration (UF) was applied to reduce free water and concentrate all blood components before the weaning from CPB.
- Trial name
- NCT05252559
- Testing
- ultrafiltration, maximal clot firmness in EXTEM assay of ROTEM test
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Konkuk University Medical Center
Cardiac Surgery, Cardiopulmonary Bypass
REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
- Trial name
- RETROCAR (NCT04979754)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Obstructive Airway Disease
In Patients With Obstructive Airway Disease, Investigate the Effects of Different Breathing Strategies and Pedaling Rates on the Physiological Response to Bicycle Exercise
The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary…
- Trial name
- NCT06332820
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Airway Aspiration, Cardiopulmonary Arrest
The Impact of Soiled Airway Management on CPR Quality
Regurgitation is an adverse event common during cardiopulmonary resuscitation (CPR) and occurs in 20%-32% of patients experiencing out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT05278923
- Testing
- SALAD simulation device
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Colorectal Cancer, Surgery
Cardiopulmonary Exercise Test Data Averaging Methods and Preoperative Risk Assessment
Cardiopulmonary exercise testing (CPET) is used for preoperative risk assessment in patients with colorectal cancer who need to undergo surgery.
- Conditions
- Colorectal Cancer, Surgery, Colorectal Neoplasms Malignant
- Trial name
- NCT05353127
- Testing
- CPET/Cardiopulmonary Exercise Test
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- VieCuri Medical Centre
Cardiac Arrest, Out-Of-Hospital
Validity of ICU Clinician's Appraisal of Proportionality in CPR
The VICAP-CPR study investigates whether doctors and nurses working in Intensive Care can determine neurological outcome and future quality of life after six months in patients treated for cardiac arrest outside the hospital…
- Trial name
- VICAP-CPR (NCT07026773)
- Where
- 9 sites in Austria, Belgium and 6 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ghent
Endothelial Dysfunction, Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs.
- Trial name
- NCT05344573
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Valvular Heart Disease, Aortic Disease
Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression.
- Trial name
- NCT02136979
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Konkuk University Medical Center
Coronary Disease
Platelet Activation Markers in Pediatric Cardiac Surgery
In this study the focus will be on correlating the levels of platelet activation markers (proteins that are released when blood cells are activated)to the duration of cardiopulmonary bypass, temperature during cardiopulmonary…
- Trial name
- NCT00450151
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Arterial Hypertension
A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial Hypertension
This multicenter, open label, Phase 2a study is designed to evaluate the effect of inhaled RT234 delivered in a dose escalation manner on the change in pulmonary vascular resistance (PVR) in subjects with Pulmonary Arterial…
- Trial name
- NCT05343637
- Testing
- Drug: RT234 - vardenafil inhalation powder; Device: RS01 dry powder inhaler (RS01 DPI)
- Where
- 3 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Respira Therapeutics, Inc.
COVID-19
Circuit Training Program in Post COVID-19 Patients
The objective of this study will be to compare the effects of Circuit Training Program on Cardiopulmonary Parameters and Functional Capacity in Post COVID 19 patients. This study will be a Randomized Clinical trial.
- Trial name
- NCT05323331
- Testing
- Circuit Training Exercise Program, Aerobic Training Exercise Program
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Heart Arrest, Ventricular Fibrillation
AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"
The aim of the trial is to evaluate a new AED algorithm that proposes a new timeline between the time devoted to administer a defibrillation shock, and the time devoted to chest compressions.
- Trial name
- DEFI2005 (NCT00139542)
- Testing
- One shock per minute AED protocol, Guidelines 2000 AED protocol
- Where
- France
- Volunteers
- 5,107 people
- Sponsor
- Fire Brigade Of Paris Emergency Medicine Dept
Cardiac Disease, Pulmonary Disease
Cardiopulmonary Outpatient Rehabilitation Using Mobile Technology
This is a randomized controlled trial of the feasibility and utility of implementing a smartphone application (MVN) to maintain compliance with a Heart Healthy lifestyle after discharge from a cardiac outpatient rehabilitation…
- Conditions
- Cardiac Disease, Pulmonary Disease, Cardiopulmonary Disease
- Trial name
- NCT02671669
- Testing
- Usual Care, Movn application (MVN)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- NYU Langone Health
Amyotrophic Lateral Sclerosis
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients
This study evaluated the influence of a tailored aerobic exercise protocol on the functional outcome in ALS patients. In addition, the investigators compare some CPET variables collected during exercise testing in both groups.
- Trial name
- NCT03326622
- Testing
- standard care, moderate exercise
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
Atrial Fibrillation
Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery
After heart surgery, about 30% of patients suffer from atrial fibrillation. Patients are randomized into two groups receiving either potentized Strychnos Nux vomica or placebo under double blind conditions.
- Trial name
- NCT00861237
- Testing
- Nux vomica (active comparator)
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Cardiopulmonary Arrest
Perception of Inappropriate CPR: a Multicenter International Cross-sectional Survey
The primary objective of this study is to determine how often cardiopulmonary resuscitation (CPR) is perceived as inappropriate by Healthcare Providers (HCPs) working in prehospital Ambulance Services and Emergency Departments.
- Trial name
- REAppropriate (NCT02356029)
- Where
- 5 sites in Belgium
- Volunteers
- 5,882 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital