Clinical trials: Cardiopulmonary Diseases
Pulmonary Disease, Chronic Obstructive
A Comparative Effectiveness Study of Mortality Outcomes and Related Cardiopulmonary Events Among a Cohort of Chronic Obstructive Pulmonary Disease (COPD) Patients Who Initiate Breztri and Multiple Inhaler Triple Therapy (MITT) in the United States (US)
Patients with chronic obstructive pulmonary disease (COPD) have elevated risk of mortality and cardiopulmonary events, particularly following exacerbations.
- Trial name
- SKOPOS:MAZI (NCT06744374)
- Testing
- BGF, MITT
- Where
- United States
- Volunteers
- 22,369 people
- Sponsor
- AstraZeneca
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Congenital Heart Disease, Mechanical Ventilation Complication
Mechanical Ventilation During Cardiopulmonary Bypass
The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs
- Conditions
- Congenital Heart Disease, Mechanical Ventilation Complication, Cardiopulmonary Bypass
- Trial name
- VENICE (NCT03629574)
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Padova
Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease
Transfusion in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB).
- Trial name
- TICVS (NCT06332547)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Guangdong Provincial People's Hospital
Diabete Type 1
Cardiopulmonary Fitness and Health-Related Quality of Life in Children and Adolescents With Type 1 Diabetes (FIT-T1D)
Children and adolescents with type 1 diabetes (T1D) are at risk of a sedentary lifestyle, as this chronic disease may lead patients into a vicious cycle of deconditioning, resulting in reduced physical activity levels and…
- Trial name
- FIT-T1D (NCT07728435)
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Institut Saint Pierre
Upper Gastrointestinal Disorders
CPET and Outcome After Oesophagogastric Cancer Surgery
Primary Aim: The present study is a retrospective analysis of prospectively collected clinical data. Anonymized data from patients collected during routine clinical care from 9 units in the United Kingdom who undertake upper…
- Trial name
- NCT03637647
- Testing
- Cardiopulmonary exercise testing
- Where
- United Kingdom
- Volunteers
- 611 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cystic Fibrosis
Prognostic Value of Functional Exercise Test (EFX) in Cystic Fibrosis
The objective of study is to prospectively determine if CPET with blood gas analysis should have a prognostic value in CF. The study plans to include 300 cystic fibrosis patients.
- Trial name
- EFX (NCT02994017)
- Testing
- cardiopulmonary exercise testing
- Where
- France
- Volunteers
- 287 people
- Sponsor
- University Hospital, Lille
Refractory Cardiac Arrest
Feasibility Study on a Prehospital Extracorporeal CardioPulmonary Resuscitation in the Pavia's Province.
This is a single Center interventional study, assessing the feasibility of a complex treatment strategy where an in-hospital standard care process is applied in an out-of-hospital cardiac arrest.
- Trial name
- eCPR on Site (NCT07155772)
- Testing
- Extracorporeal CardioPulmonary Resuscitation (eCPR)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Ischemic Heart Disease
Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass
Ischemic heart disease is one of the most frequent diagnoses in the VA system. Moreover, 5,819 coronary artery bypass graft (CABG-only) procedures were performed in the VA in Fiscal Year (FY) 1999.
- Trial name
- ROOBY (NCT00032630)
- Testing
- Coronary artery bypass - on-pump, Coronary artery bypass - off-pump
- Where
- 17 sites in United States
- Volunteers
- 2,203 people
- Sponsor
- US Department of Veterans Affairs
Cardiopulmonary Arrest
Appropriate Number of Endotracheal Intubation Experience for CPR
This is a clinical study based on analysis of video-clip data of intubation and clinical data for cardiopulmonary resuscitation patients between 2011.03.01.-2012.02.28..
- Trial name
- NCT03423745
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Konkuk University Medical Center
Heart Failure, Athletes Heart
Cardiopulmonary and Right Ventricular Function in Health and Disease
The primary objective of this research protocol is to advance the understanding of cardiopulmonary and right ventricular (RV) performance among individuals with cardiomyopathy (heart failure with reduced ejection fraction…
- Trial name
- NCT04147299
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Coronary Artery Disease, Aortic Valve Disease
Clinical Evaluation of a Modular Extracorporeal Circulation Circuit
The purpose of this clinical research study is the design of a novel modular hybrid system extracorporeal circulation circuit for open heart procedures that could easily be converted from a closed to a semi-closed circuit…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease, Aortic Aneurysm
- Trial name
- MiECC MODULAR (NCT02000544)
- Testing
- Modular Cardiopulmonary Bypass Circuit
- Where
- Greece
- Volunteers
- 403 people
- Sponsor
- AHEPA University Hospital
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication
This randomized controlled trial aims to investigate the impact of conduction system pacing in comparison to right ventricular apical pacing on exercise capacity, as measured by peak oxygen uptake (VO2peak), in heart failure…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Heart Conduction Disorder
- Trial name
- ESCPAND (NCT06278844)
- Testing
- Conduction system pacing, Right ventricular apical pacing
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Kidney Failure, Acute
Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery.
- Trial name
- EVOLVE (NCT00445809)
- Where
- 11 sites in United States, Canada
- Volunteers
- 355 people
- Sponsor
- Abbott RDx Cardiometabolic
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Cardiac Arrest
A Comparison of CPR Outcomes Between Traditional and Endomorphic Manikins With and Without Equipment
The study's research design is a randomized experiment. 50 emergency responders (emergency medical responders, emergency medical technicians, advanced emergency medical technicians, and paramedics) will be recruited for this…
- Trial name
- NCT04283214
- Testing
- Cardiopulmonary Resuscitation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Cardiorespiratory Arrest
Impact of Realistic Simulation Training on Nurses' Cardiopulmonary Resuscitation Performance
Introduction: Cardiopulmonary arrest is one of the most prevalent cardiovascular emergencies worldwide, associated with high morbidity and mortality.
- Trial name
- SIM-CPR Nurses (NCT07623447)
- Testing
- CPR training for nurses with the use of electrical therapy
- Where
- Brazil
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Apnea, Cardiopulmonary Resuscitation
Head Positions to Open the Upper Airway
Ventilation during basic life support improves survival in cardiac arrest patients significantly. Unfortunately, this is in contrast to the willingness of potential rescuers to perform mouth-to-mouth ventilation.
- Trial name
- NCT00869648
- Testing
- Extension, Neutral head position, Anaesthesiologist's position
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Cardiac Surgical Procedures
Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery
Cardiopulmonary bypass-assisted surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g.
- Trial name
- NCT03163238
- Testing
- Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
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