Clinical trials: Cardiopulmonary Diseases
Spinal Cord Injury
The Effect of Neck Stabilization Exercise Plus Cardiopulmonary Rehabilitation on Pulmonary Function of SCI
Cervicocranial flexion exercise (CCFE) and superficial neck flexor endurance training have been widely implemented in clinical practice for curing chronic neck pain.
- Trial name
- NCT04500223
- Testing
- Cervical Cranioflexion exercise plus cardiopulmonary exercise, Cervical stretch exercise plus cardiopulmonary rehabilitation
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Taoyuan General Hospital
Ischemic Heart Disease
Exploration of Cerebral Pathophysiology During and After CABG Using CPB
Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
- Trial name
- NCT02941380
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Arrest, Heart Disease
A Mannequin Study to Assess Various CPR Training Methods Using a Student Population
Prompt delivery of cardiopulmonary resuscitation (CPR) can double a victims chance of survival from cardiac arrest (CA), yet it is provided in less than 1/3 of witnessed events.
- Trial name
- NCT01833910
- Testing
- AHA CPR Anytime Video Self-Instruction Kit, AHA CPR Anytime DVD
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Renal Failure, Coronary Artery Disease
Prevent Cardiac Surgery Associated AKI Trial
Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily…
- Conditions
- Renal Failure, Coronary Artery Disease, Surgery, Surgery-Complications
- Trial name
- NCT06620523
- Testing
- CoQ10 1200 mg orally with Glutathione 1000 mg orally
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- George Washington University
Pregnancy, Cardiac Arrest
Influence of the Method of Alleviation of Aorto-Caval Compression on the Trans-Hepatic Ultrasound-Assessed Inferior Vena Cava Diameter In Pregnant Patients
Cardiac arrest during pregnancy is rare but may result in poor maternal and fetal outcome. Because of its rare occurrence and ethical issues this topic is not very well studied and many questions pertaining to maternal…
- Trial name
- NCT01982513
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Out-of-Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
Refractory Cardiac Arrest Treated On Field By ECMO
Out-of-hospital cardiac arrest without resumption of spontaneous circulatory activity despite advanced medical resuscitation is considered refractory.
- Trial name
- ReCATOBE (NCT06397417)
- Testing
- Data collection
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Cardiopulmonary Resuscitation
Cardiac Arrest Extra Corporeal Oxygenation Membrane
French guidelines for Cardio Pulmonary Resuscitation (CPR) consider Extra-Corporeal Life Support (ECLS) as one option in Refractory out-of hospital Cardiac Arrest (ROHCA) patients with a no-flow less than five minutes and absence…
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Advanced Cardiac Life Support, Extracorporeal Life Support
- Trial name
- CAREECMO (NCT03352999)
- Testing
- Fast track access to vaECMO
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Interstitial Lung Diseases
Advanced Mutidimensional and Ultra High Resolution Computed Tomography to Inspect Cardiopulmonary Involvement in Progressive Fibrosing Interstitial Lung Diseases
Interstitial lung diseases (ILDs) are common chronic disease characterized by high mortality and morbidity, also linked to cardiovascular implication.
- Trial name
- AMICI-ILD (NCT06537934)
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- IRCCS San Raffaele
Pulmonary Hypertension
PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the safety and effectiveness of tadalafil for the treatment of pulmonary arterial hypertension.
- Trial name
- NCT00125918
- Testing
- tadalafil
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 406 people
- Sponsor
- Eli Lilly and Company
Mild Pulmonary Hypertension
A Randomized Trial of Udenafil Therapy in Patients With Mild Pulmonary Hypertension [ULTIMATE-Mild PHT]
The investigators hypothesized that udenafil, a newly developed phosphodiesterase type 5 inhibitor, would improve symptom, exercise capacity and hemodynamic status in patients with mild pulmonary hypertension.
- Trial name
- NCT01696240
- Testing
- Udenafil (Zydena)
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Out of Hospital Cardiac Arrest, Computed Tomography
Timing for Computed Tomography and Post-Resuscitation Care on Short-Term Outcomes in Out-of-Hospital Cardiac Arrest
This retrospective multicenter study investigates the association between the timing of computed tomography (CT) scans and short-term outcomes in adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients who achieved…
- Trial name
- NCT06936917
- Volunteers
- 5,000 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU
Ischemic acute tubular necrosis (ATN) is one of the main cause of acute kidney injury (AKI) in intensive care units (ICU). Sepsis and cardio-pulmonary bypass (CPB) are major providers.
- Trial name
- FURTHER (NCT03731117)
- Testing
- Furosemide
- Where
- 3 sites in France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest
Safety and Feasibility of Endovascular Cooling Device in Patients With Hypothermic Cardiopulmonary Resuscitation
Hypothermic resuscitation is proven to be benefit to the cardiac origin cardiac arrest patients for it improve brain recovery dramatically.
- Trial name
- NCT00154674
- Testing
- ICY catheter, Thermoguard device
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Amyotrophic Lateral Sclerosis
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients
This study evaluated the influence of a tailored aerobic exercise protocol on the functional outcome in ALS patients. In addition, the investigators compare some CPET variables collected during exercise testing in both groups.
- Trial name
- NCT03326622
- Testing
- standard care, moderate exercise
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
ARDS Due to Disease Caused by SARS Co-V-2, Right Ventricular Dysfunction
Cardiopulmonary Effects of Prone Position in CARDS
In coronavirus disease-2019 (COVID-19)-related ARDS (C-ARDS), especially in the severe form, increased shunt rate, impaired ventilation/perfusion ratio (V/Q), hypoxic pulmonary vasoconstriction inhibition, and increased immune…
- Trial name
- NCT06456606
- Testing
- before prone position, the first hour of prone position, the first hour of returning to the supine position
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Cardiopulmonary Disease
Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases
Researchers are trying to develop innovative strategies that target the early identification heart and lung imbalances in patients with cardiopulmonary diseases.
- Trial name
- NCT03911856
- Testing
- Echocardiography, Pulmonary Gas Exchange
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
COPD Exacerbation, COPD
The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events
A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization…
- Conditions
- COPD Exacerbation, COPD, Cardio/Pulm: Heart Failure
- Trial name
- NCT06379529
- Testing
- NuvoAir clinical service
- Volunteers
- 1,050 people
- Sponsor
- NuvoAir Medical PC
Colorectal Neoplasms
Preop CPET Testing and Exercise Training in Colorectal Patients
Colorectal Surgery Preoperative Exercise Training is a study being run by the colorectal surgery team at the Norfolk and Norwich University Hospital and the University of East Anglia to look at the role of exercise before surgery…
- Trial name
- NCT01924897
- Testing
- Exercise training
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of East Anglia
Chest Pain, Dyspnea
Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Department
The purpose of the proposed research is to examine whether incorporating point-of-care ultrasound (POCUS) early in diagnostic work-up of cardiopulmonary complaints will affect diagnosis, time to condition-specific intervention…
- Conditions
- Chest Pain, Dyspnea, Syncope, Hypotension
- Trial name
- NCT02861508
- Testing
- Point-of-care ultrasound, Usual care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Yale University
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