Clinical trials: Cardiopulmonary Diseases
Lung Injury, Acute
Lung Protection and Pediatric Cardiac Surgery
The lung is at risk for ischemic insults during total cardiopulmonary bypass because lung perfusion is maintained solely by the bronchial arterial system
- Trial name
- NCT03023670
- Testing
- cardiopulmonary bypass
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome, Acute Cor Pulmonale
Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO
Recent data from large trials of high-frequency high frequency oscillation (HFO) without a cuff leak vs, lung-protective conventional ventialtion (CMV) failed to show any HFO-related benefit with respect to outcome.
- Trial name
- NCT02027129
- Testing
- High Frequency Oscillation
- Where
- Greece
- Volunteers
- 17 people
- Sponsor
- University of Athens
Shortness of Breath Episode, Tachycardia
Verification of Prediction Algorithm
Prospective observational clinical study to verify an algorithm used to predict cardiopulmonary events in patients presenting to the emergency department.
- Conditions
- Shortness of Breath Episode, Tachycardia, Bradycardia, Difficulty Breathing
- Trial name
- VPAC (NCT02863666)
- Where
- 3 sites in United States, Belgium
- Volunteers
- 673 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest (CA)
Effectiveness of a Communication Training Program in Improving the Handling of Calls for Suspected Cardiac Arrest at SAMU-Centre 15.
Each year, France's emergency response services-the SAMU (15) and the fire department (18)-handle 31 million and 19 million calls, respectively.
- Trial name
- COM-ARM (NCT07776990)
- Testing
- Multifaceted intervention including 4 components
- Where
- 10 sites in France
- Volunteers
- 987 people
- Sponsor
- University Hospital, Grenoble
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Heart Failure, Respiratory Failure
Heart And Lung Failure - Pediatric INsulin Titration Trial
Stress hyperglycemia, a state of abnormal metabolism with supra-normal blood glucose levels, is often seen in critically ill patients.
- Trial name
- HALF-PINT (NCT01565941)
- Testing
- Insulin
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 713 people
- Sponsor
- Boston Children's Hospital
Chest Pain, Dyspnea
ER-VISION-AI Study
Prospective, multicenter, randomized, open-label, blinded-endpoint (PROBE-like) clinical trial evaluating whether physician-supervised Generative Pre-trained Transformer (GPT)-assisted multimodal diagnostic support improves…
- Conditions
- Chest Pain, Dyspnea, Acute Cardiopulmonary Disease, Emergency Department Patients
- Trial name
- ER-VISION-AI (NCT07727590)
- Testing
- Generative Pre-trained Transformer (GPT)-assisted multimodal visual language model (VLM) diagnostic support, Conventional emergency department diagnostic evaluation
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Out-of-hospital Cardiac Arrest (OHCA)
Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major global public health challenge. Despite continuous advancements in resuscitation strategies, overall survival rates remain low.
- Trial name
- EXECT-CPR-2 (NCT07909642)
- Testing
- Transesophageal Echocardiography-Guided Chest Compression, Conventional Cardiopulmonary Resuscitation
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Far Eastern Memorial Hospital
Inflammation, Platelet Dysfunction
Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet Activation
Open heart surgery requires the use of a cardiopulmonary bypass (CPB) circuit. As blood flows across the artificial surfaces of the CPB circuit, platelets are activated and consumed.
- Trial name
- NCT03455218
- Testing
- Nitric Oxide, INOmax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Abdominal Aortic Aneurysm
The Inter and Intra Reliability of Cardiopulmonary Exercise Testing in Abdominal Aortic Aneurysm Patients
Exercise testing is commonly being used in patients before surgery to test their overall fitness. One group it is being used in is patients who have an enlarged blood vessel in their stomach.
- Trial name
- CPEX (NCT02973308)
- Testing
- Observer
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Cardiac Surgical Procedures, Coronary Artery Bypass
Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery
TALEN is a prospective randomised double-blind placebo-controlled phase 2 study of 5-Aminolevulinic Acid with Sodium Ferrous Citrate (5-ALA-SFC) in adult patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Bypass, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- TALEN (NCT07027670)
- Testing
- 5-Aminolevulinic Acid hydrochloride (5-ALA), Sodium ferrous citrate (SFC)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Coronary Artery Disease, Mitral Valve Regurgitation
Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery
The purpose of this study is to evaluate the effect of a single dose of etomidate for patients undergoing cardiac surgery with the use of cardiopulmonary bypass (CPB) on post-CPB adrenocortical responsiveness, on requirements of…
- Trial name
- NCT00415701
- Testing
- Etomidate, Propofol, Hydrocortisone
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Pulmonary Arterial Hypertension
A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial Hypertension
This multicenter, open label, Phase 2a study is designed to evaluate the effect of inhaled RT234 delivered in a dose escalation manner on the change in pulmonary vascular resistance (PVR) in subjects with Pulmonary Arterial…
- Trial name
- NCT05343637
- Testing
- Drug: RT234 - vardenafil inhalation powder; Device: RS01 dry powder inhaler (RS01 DPI)
- Where
- 3 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Respira Therapeutics, Inc.
Bypass, Cardiopulmonary
Menthol Massage for Post-Bypass Pain & Anxiety
This randomized controlled trial aims to evaluate the effectiveness of mentholated ointment massage in reducing pain and anxiety levels in patients who have undergone coronary bypass surgery, volunteered to participate in the…
- Trial name
- Menthol Care (NCT07508371)
- Testing
- Menthol Massage, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Cardiac Arrest, Cardiopulmonary Arrest
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression…
- Trial name
- pediRES-Q (NCT02708134)
- Where
- 63 sites in United States, Australia and 13 more
- Volunteers
- 7,000 people
- Sponsor
- Children's Hospital of Philadelphia
Coronary Artery Disease
Home-Based Versus Center-Based Cardiac Rehabilitation After CABG Surgery
This randomized controlled trial was designed to compare the efficacy of a 12-week home-based telerehabilitation (HBTCR) program against traditional center-based cardiac rehabilitation (CBCR) and usual care in patients who have…
- Trial name
- NCT07243444
- Testing
- Structured Exercise Program, Standard Health Education
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Hospital of Hebei Medical University
Chronic Obstructive Pulmonary Disease
Air Pollution and Health of COPD Patients
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
- Trial name
- NCT05076630
- Testing
- Air pollutants
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University
Obstructive Sleep Apnea of Adult
Effects of Rehabilitation for Patients With Obstructive Sleep Apnea
In previous review study, it was hypothesized that a comprehensive rehabilitation can combine both local pharyngeal muscle exercise and systemic cardiopulmonary rehabilitation for the OSA patients with oropharyngeal muscle…
- Trial name
- NCT03940781
- Testing
- comprehensive rehabilitation
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- National Cheng-Kung University Hospital
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