Clinical trials: Cardiopulmonary Diseases
Cardiopulmonary Bypass, Coronary Artery Disease
Cardiopulmonary Bypass (CPB) Pumps and Blood Activation
Blood activation induced by cardiopulmonary bypass may compromise the postoperative outcome. The goal of this study is to compare blood activation induced by cardiopulmonary bypass performed with centrifugal pump or roller pump…
- Trial name
- NCT00187967
- Testing
- pumps used for cardiopulmonary bypass
- Where
- France
- Sponsor
- University Hospital, Angers
Delirium
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery
The purpose of this study is to evaluate the efficacy and safety of dexmedetomidine in the prevention of postoperative delirium in subjects undergoing heart valve surgery with or without coronary artery bypass surgery (CABG)…
- Trial name
- NCT00464763
- Testing
- Dexmedetomidine
- Where
- 11 sites in United States
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to…
- Conditions
- Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation, Interstitial Lung Disease, Acute Lung Injury
- Trial name
- NCT07613099
- Testing
- [18F]FAPI-74, 18F-FAPI-74 PET/CT Imaging
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Arrest (CA), Cardiopulmonary Resuscitation
RescueDoppler- a Disruptive Ultrasound Solution for Improved Outcome After Cardiac Arrest.
RescueDoppler is an innovative, hands-free Doppler system designed for continuous monitoring of blood flow in the carotid artery, distinguishing between the presence and absence of a pulse.
- Conditions
- Cardiac Arrest (CA), Cardiopulmonary Resuscitation, Doppler Ultrasound
- Trial name
- RescueDoppler (NCT06599073)
- Testing
- RescueDoppler, Rescue
- Where
- 8 sites in Norway, Sweden
- Volunteers
- 285 people
- Sponsor
- Norwegian University of Science and Technology
Heart Disease, Acute Renal Failure
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery.
- Trial name
- NCT00188630
- Testing
- N-acetylcysteine, 5% dextrose solution
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University Health Network, Toronto
Cardiopulmonary Arrest, Pediatric ALL
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
The International Liaison Committee on Resuscitation regularly publishes a Consensus on Science with Treatment Recommendations but guidelines can nevertheless differ when knowledge gaps persist.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- NCT05474170
- Testing
- AHA resuscitation sequence, ERC resuscitation sequence
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Covid19, Acute Cor Pulmonale
Cardiac Performance in Mechanically Ventilated COVID-19 Patients
Although COVID-19 affects primarily the respiratory system, several studies have shown evidence of cardiovascular alterations. Increased troponin levels were observed in a significant proportion of patients and this alteration…
- Conditions
- Covid19, Acute Cor Pulmonale, Cardiac Failure
- Trial name
- NCT04628195
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Pulmonary Dysfunction
Different Modes of Ventilation During Cardiopulmonary Bypass
66 patients divided into 3 groups with different modes of ventilation.
- Trial name
- NCT03824301
- Testing
- Volume controlled ventilation, Pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Congenital Heart Disease
Effect of Retrograde Autologous Blood Priming on Pulmonary Mechanics in Pediatric Cardiac Surgery
The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.
- Trial name
- RAPCPB (NCT04260204)
- Testing
- Pediatric cardiac surgery
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Out-of-Hospital Cardiac Arrest
Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Background： Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage has been shown that survival to discharge rate is poor.
- Trial name
- NCT00965016
- Testing
- hypothermia
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Min-Sheng General Hospital
Longitudinal Studies, Prospective Studies
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
TH-CLINICAL-TIME is a prospective, longitudinal observational study evaluating how changes in clinical measurements over time may help researchers better understand patient health trajectories and clinically meaningful outcomes.
- Conditions
- Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
- Trial name
- CLIN-TIME (NCT07812831)
- Testing
- No Study-Assigned Intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Covid19
Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19
Background: Respiratory and cardiovascular complications have emerged as dominant threats during and following coronavirus disease (COVID19) infection.
- Trial name
- NCT04887272
- Testing
- Supervised Exercise Training Protocol, Inspiratory Muscle and Exercise Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois Chicago
Heart Failure With Reduced Ejection Fraction
CPET Predicts Long-term Survival and Positive Response to CRT
The study tested the usefulness of cardiopulmonary exercise test (CPET) in selection of potential responders to CRT.
- Trial name
- CPET-CRT (NCT03870074)
- Volunteers
- 122 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Cardiovascular Disease, Cardiopulmonary Bypass
Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)
Cardiovascular diseases (CVDs) continue to be the primary cause of illness and death globally, emphasizing the pressing requirement for efficient prevention methods.
- Trial name
- PANDA (NCT04444362)
- Testing
- Intestinal Microbiota Transplant (IMT) Capsules
- Where
- 5 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Airway Aspiration, Cardiopulmonary Arrest
The Impact of Soiled Airway Management on CPR Quality
Regurgitation is an adverse event common during cardiopulmonary resuscitation (CPR) and occurs in 20%-32% of patients experiencing out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT05278923
- Testing
- SALAD simulation device
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Colorectal Cancer, Surgery
Cardiopulmonary Exercise Test Data Averaging Methods and Preoperative Risk Assessment
Cardiopulmonary exercise testing (CPET) is used for preoperative risk assessment in patients with colorectal cancer who need to undergo surgery.
- Conditions
- Colorectal Cancer, Surgery, Colorectal Neoplasms Malignant
- Trial name
- NCT05353127
- Testing
- CPET/Cardiopulmonary Exercise Test
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- VieCuri Medical Centre
Tracheal Intubation, Postoperative Complications (Cardiopulmonary)
Tracheal Cuff Pressure and Postoperative Complications
This prospective observational study aims to identify risk factors for tracheal mucosal injuries caused by orotracheal tube use during the intraoperative period in patients undergoing elective surgeries at the Hospital de…
- Trial name
- TCP-POC (NCT07264179)
- Where
- Brazil
- Volunteers
- 362 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiac Disease, Respiratory Disease
Clinical Use Cases Assessment of the Gabi System in Young Children With Underlying Medical Conditions (BRIDGE Study)
Subjects will use the Gabi system on a daily basis for 3 months, each time the subject is resting or asleep. The Gabi system will recording the SpO2, pulse rate, respiratory rate and movements of the subject.
- Conditions
- Cardiac Disease, Respiratory Disease, Congenital Cardiac Defect, Cardiovascular Diseases
- Trial name
- BRIDGE (NCT05319236)
- Testing
- Gabi System
- Where
- 4 sites in United States, Belgium
- Volunteers
- 101 people
- Sponsor
- Gabi SmartCare
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