Clinical trials: Cardiopulmonary Diseases
Congenital Heart Surgery, Cardiopulmonary Bypass
Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
Cardiopulmonary bypass [CPB] in small size bodies can result in decreased peripheral perfusion. This results in anaerobic metabolism as evidenced by lactic acidosis.
- Trial name
- NCT00620945
- Testing
- Phenoxybenzamine
- Volunteers
- 87 people
- Sponsor
- The Cleveland Clinic
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Critical Illness
CPR Audiovisual Tool to Impact ICU Patients' Surrogate Anxiety Level.
Video or No Video to decrease HCPOA/LAR anxiety and increase knowledge as it pertains to CPR.
- Trial name
- NCT03630965
- Testing
- CPR Video
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Medical College of Wisconsin
Mitral Regurgitation, Pulmonary Hypertension
The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
Mitral regurgitation (MR) is a prevalent valvular heart pathology. Indications for surgery include symptoms, impaired left ventricular function or enlarging dimensions, new onset atrial fibrillation, pulmonary hypertension…
- Trial name
- RIPCOM1 (NCT03155373)
- Testing
- Cardiac catheterisation, Cardiopulmonary exercise testing, Pulmonary function tests
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Pulmonary Atelectasis
Ventilation During Cardiopulmonary Bypass (CPB) for Cardiac Surgery
During most types of heart surgery cardiopulmonary bypass (CPB) is used. CPB enables blood to be directed away from the heart and the lungs and pumped through the body while the heart is not beating.
- Trial name
- NCT02070445
- Where
- Canada
- Sponsor
- McMaster University
Tricuspid Regurgitation
Tricuspid Cardiopulmonary Exercise Study
Tricuspid regurgitation (TR), which in close to 90% of cases is functional as a consequence of left-sided heart failure, left heart valve abnormalities or pulmonary (vascular) disease, is associated with adverse patient outcomes…
- Trial name
- TRCPET (NCT04559256)
- Testing
- Cardiopulmonary Exercise Testing
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Valve Disease, Aortic, Cardiac Rehabilitation
Effects of MICT on Cardiopulmonary Function in Patients After TAVI
Cardiac rehabilitation (CR), particularly regular exercise, can improve the cardiopulmonary function, exercise capacity, and quality of life for patients undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- NCT05015712
- Testing
- moderate intensity continuous training
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Han Yaling, MD
Cardiac Arrest
The Schmitz-Hinkelbein Method. A New Technique for CPR in Space.
The risk of a severe medical event during long-duration spaceflight is significant and can endanger both the whole mission and crew.
- Trial name
- NCT04354883
- Testing
- External Chest Compressions on Manikin in Underwater Setting
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
COPD, Bronchial Asthma
Effects of Pulmonary Diseases and Their Treatment on Cardiac Function
While the bidirectional relationship between the lung and the right heart are well studied, the cardiopulmonary interactions between the lung and the left heart are largely unresearched and not well understood.
- Conditions
- COPD, Bronchial Asthma, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT05042219
- Testing
- Cardiac MRI
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Ayham Daher
Atrial Fibrillation, Heart Failure
Cardiopulmonary Bypass and Ventricular Remodeling
The goal of this observational study is determine if reduced ventricular ejection fraction is a factor that determines a pro-oxidant imbalance in patients subjected to cardiac surgery with cardiopulmonary bypass.
- Trial name
- CBP-VR (NCT06256965)
- Testing
- Detection of peri-operative atrial fibrillation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- University of Chile
Aortic Valve Stenosis
CPX in Paradoxical Low Flow Aortic Stenosis
Severe aortic stenosis is a condition with poor life expectancy once it becomes symptomatic. There are no prospective studies illustrating the utility of cardiopulmonary stress (CPX) testing in diagnosing and prognosticating…
- Trial name
- NCT05481814
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Spinal Cord Injuries, Cardiovascular Diseases
The Swedish Spinal Cord Injury Study on Cardiopulmonary and Autonomic Impairment
The main aim of this study is to gain an in-depth knowledge of cardiopulmonary and autonomic health consequences, and related risk factors among people with long-term high-level spinal cord injury.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Pulmonary Disease, Autonomic Dysfunction
- Trial name
- SPICA (NCT03515122)
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Lund University
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Cardiac Surgery
Optimization Strategy for Oxygen Delivery Under Cardiopulmonary Bypass
Cardiac surgery is a frequent procedure that can lead to serious complications, including acute kidney injury (AKI) or postoperative delirium.
- Trial name
- OPTI-DO2 (NCT05984563)
- Testing
- Cardiopulmonary bypass
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Heart Failure
Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients
The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.
- Trial name
- MUSIC-CPX (NCT05537467)
- Testing
- Music
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Maya Ignaszewski
Systemic Inflammatory Response Syndrome, Cardiac Diseases
Dexamethasone for Cardiac Surgery Trial
This is a multicenter, randomized, double-blind trial, comparing clinical outcomes after the administration of high-dose dexamethasone versus placebo in patients undergoing heart surgery with the use of cardiopulmonary bypass.
- Conditions
- Systemic Inflammatory Response Syndrome, Cardiac Diseases, Postoperative Complications
- Trial name
- NCT00293592
- Testing
- Dexamethasone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
Angina, Stable, Congestive Heart Failure
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
This feasibility trial will focus on older adults 60+ who are candidates for cardiac or pulmonary rehabilitation and who are vulnerable, mildly or moderately frail.
- Conditions
- Angina, Stable, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05562037
- Testing
- Stepped Care
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Peter Lindenauer, MD
Heart Failure, Iron-deficiency
Effects of IV Iron Replacement on Exercise Capacity in Individuals With Heart Failure
Patients with heart failure with reduced ejection fraction and iron deficiency will be randomized to either receive iron infusion or be in the control group.
- Trial name
- NCT05816265
- Testing
- IV Iron Infusion Group
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Radha Gopalan
Acute Kidney Injury
Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality
Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are…
- Trial name
- NCT02916043
- Testing
- Cardiovascular surgery with cardiopulmonary bypass
- Where
- South Korea
- Volunteers
- 1,099 people
- Sponsor
- Seoul National University Hospital
Heart Failure
Correlation of the Non-invasive Cardiopulmonary Management (CPM) Wearable Device With Measures of Congestion in Heart Failure
Fluid status and congestion can be determined by the CPM wearable device and correlates with invasive measures, non-invasive measures and biochemical markers of congestion and changes in congestion.
- Trial name
- CONGEST HF (NCT05026034)
- Testing
- non-invasive Cardiopulmonary Management (CPM) wearable device
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- NHS Greater Glasgow and Clyde
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