Clinical trials: Cardiopulmonary Diseases
Hyperlactatemia, Cardiac Disease
Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation
The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.
- Conditions
- Hyperlactatemia, Cardiac Disease, Bypass Complication, Valve Disease, Heart
- Trial name
- NCT04046861
- Testing
- ascorbic acid,
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Maribor
Pulmonary Atelectasis
Ventilation During Cardiopulmonary Bypass (CPB) for Cardiac Surgery
During most types of heart surgery cardiopulmonary bypass (CPB) is used. CPB enables blood to be directed away from the heart and the lungs and pumped through the body while the heart is not beating.
- Trial name
- NCT02070445
- Where
- Canada
- Sponsor
- McMaster University
Kidney Injury
Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection: A Proof of Concept Pilot Study
One of the major complications of heart surgery is kidney injury, which occurs in up to 30% of patients and is associated with poor outcomes including death.
- Trial name
- NCT00861822
- Testing
- Advanced red blood cell transfusion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
COPD, Pulmonary Hypertension Secondary
CPET in Evaluation of PH in COPD Patients
To evaluate the entire course of exercise during CPET in COPD patients. To study whether CPET, PFTs and arterial blood gases could discriminate between COPD patients with and without PH.
- Trial name
- NCT04035148
- Testing
- Cardiopulmonary exercise test
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiopulmonary Surgery, Endocarditis
Cytosorb Therapy in Cardiac Surgery
Cardiopulmonary surgery is associated with inflammatory responses that can lead to systemic inflammatory responses (SIRS), organ dysfunction (MOD) and death especially in patients with endocarditis.
- Conditions
- Cardiopulmonary Surgery, Endocarditis, Peri-operative Cytokines Levels
- Trial name
- NCT04309591
- Testing
- CytoSorb haemoadsorption (HA) device
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- University Hospital, Basel, Switzerland
Pulmonary Embolism With Acute Cor Pulmonale
Catheter-directed Thrombectomy in High and Intermediate-high Risk Pulmonary Embolism
Pulmonary embolism is one of the leading causes of cardiovascular death. Pulmonary embolism may be life-threatening condition with an estimated 30-day mortality rate about 10-30%.
- Trial name
- CATH-PE (NCT04473560)
- Testing
- Catheter-directed thrombectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Out-of-hospital Cardiac Arrest
The PulsePoint Randomized Controlled Trial
"Sudden cardiac arrest" occurs when someone's heart stops beating unexpectedly. Each year, more than 45,000 Canadians have a cardiac arrest.
- Trial name
- NCT01746290
- Testing
- PulsePoint notification
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
COVID-19 Pneumonia, COVID-19
The Aerobic Exercise Capacity and Muscle Strenght in Individuals With COVID-19
The subject of the project is the impact of COVID-19 on the exercise capacity of patients. The long-term sequelae of COVID-19 infection are still unknown.
- Trial name
- NCT06272266
- Testing
- Kardiopulmonary exercise test (Quark KPET C12x/T12x device connected to the Omnia version 1.6.8 COSMED system), Peripheral muscle strength measurement (microFET3 (Hoggan Health Industries, Fabrication Enterprises, lnc) and JAMAR hydraulic hand dynamometer (Sammons Preston, Rolyon, Bolingbrook)., Standard exercise tolerance test (a bicycle ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.)
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Selda Sarıkaya
Cardiopulmonary Bypass, Cardiac Surgery
Cardiopulmonary Bypass Induced Red Blood Cell Lysis
Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Kidney Injury, Acute
- Trial name
- NCT05189262
- Testing
- Blood and urine collection
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Maryland, Baltimore
Cardiac Surgery, Cardiopulmonary Bypass
REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
- Trial name
- RETROCAR (NCT04979754)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
COVID-19, COPD
Breather Trainer Versus Pulmonary Rehabilitation on Cardiopulmonary Efficiency
The purpose of the study is to determine the difference between The Breather respiratory muscle trainer and pulmonary rehabilitation in patients with COPD post COVID-19.
- Trial name
- NCT05382780
- Testing
- The breather respiratory muscle trainer, Diaphragmatic and localized breathing exercises, interval aerobic training and respiratory training
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Horus University
Heart Failure
Assessment of Heart Failure (HF) At-Home Management Solution ADI Cardio Pulmonary Monitoring System (CPM)
This study is meant primarily to assess the deployment of the ADI CPM System in a clinical setting and determine interoperability of the CPM System within existing care pathways for patients with CHF.
- Trial name
- NCT05980585
- Testing
- CPM Device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Analog Device, Inc.
Hypothermia, Cerebral Perfusion
Assessment of the Cerebral Perfusion During the Period of Deep Hypothermia at 18°C in Patient Undergoing Pulmonary Endarterectomy Surgery.
Cardiopulmonary bypass (CPB) surgery present risk of acute postoperative neurological complications. These complications are most often postoperative cognitive dysfunction (confusion, cognitive disorders, executive disorders)…
- Conditions
- Hypothermia, Cerebral Perfusion, Transcranial Doppler Ultrasound, Pulmonary Hypertension
- Trial name
- HYPO-TEP (NCT06250374)
- Testing
- Bilateral trans-cranial Doppler ultrasound
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Cardiac Arrest, Out of Hospital Cardiac Arrest
Compression Only-CPR Versus Standard-CPR
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is a positive predictor of survival.
- Trial name
- TANGO2 (NCT02401633)
- Testing
- CO-CPR, S-CPR
- Where
- Sweden
- Volunteers
- 1,250 people
- Sponsor
- Karolinska Institutet
COPD (Chronic Obstructive Pulmonary Disease)
Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life With Chronic Obstructive Pulmonary Disease
This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training…
- Trial name
- NCT06869720
- Testing
- Eccentric bike, conventional group
- Where
- Taiwan
- Sponsor
- Fu Jen Catholic University
Coronary Heart Disease
The Effect on Fluid Balance After Cardiac Surgery After Use of Two Different Priming Protocols
"The impact on fluid loading after cardiac surgery by use of two different priming solution" Fluid overloading with oedema formation is a regular finding following on-pump cardiac surgery and may contribute to postoperative organ…
- Trial name
- NCT01511120
- Testing
- Tetraspan, acetated Ringer's solution
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Haukeland University Hospital
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Rheumatic Disease of Heart Valve, Ischemic Reperfusion Injury
Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
- Trial name
- NCT01476969
- Testing
- Remote ischemic postconditioning
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Central South University
Cardiopulmonary Bypass
Changes in Plasma Osmolality Related to the Use of Cardiopulmonary Bypass With Hyperosmolar Prime.
During the use of Cardiopulmonary Bypass (CPB) for cardiac surgery there is an instant mixture of the patient's blood and the fluid needed to fill the extracorporeal circuit before use.
- Trial name
- NCT03060824
- Testing
- Blood sampling
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Umeå University
Atrial Fibrillation, Atrial Arrhythmia
Ergospirometry in Paroxysmal Atrial Fibrillation Prognosis
An observational, prospective, cohort study aiming to assess the potential predictive role of cardiopulmonary exercise testing in the prognosis of paroxysmal atrial fibrillation, in combination with echocardiographic indices and…
- Trial name
- PLACEBO (NCT05246423)
- Testing
- Observation group
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
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