Clinical trials: Cardiopulmonary Diseases
Ventricular Septal Defect
Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation?
The purpose of this trial is to study if priming the pump used during cardiac surgery with non-blood fluids instead of donated blood products reduces the inflammation that occurs after heart surgery.
- Trial name
- NCT07393243
- Testing
- Clear priming of the bypass pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Heart Defects, Congenital, Cardiopulmonary Bypass
Nesiritide Use Following Cardiac Surgery in Infants
The purpose of this study is to determine the effects of nesiritide on urine output and hemodynamics following cardiopulmonary bypass in infants. Safety and pharmacokinetic data will also be obtained.
- Trial name
- NCT00281671
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
Cardiac Arrest
The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR
The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating…
- Trial name
- NCT02479152
- Testing
- LUCAS2 AD
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Physio-Control
Anesthesia, Propofol Adverse Reaction
Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using…
- Conditions
- Anesthesia, Propofol Adverse Reaction, Etomidate Adverse Reaction, Anesthesia Complication
- Trial name
- PEAC (NCT05358535)
- Testing
- Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiopulmonary Testing in ME/CFS to Improve Diagnostic Accuracy
Circumstantial evidence suggests that patients diagnosed with myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) perform worse on day 2 in a 2-day consecutive cardiopulmonary exercise test (CPET).
- Trial name
- NCT02970240
- Testing
- Cardiopulmonary testing
- Where
- Norway
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Diastolic Heart Failure
A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF]
The investigators hypothesized that udenafil, a newly developed phosphodiesterase type 5 inhibitor, would improve symptom, exercise capacity and hemodynamic status in patients with heart failure with preserved ejection fraction…
- Trial name
- NCT01599117
- Testing
- Udenafil (Zydena)
- Where
- 2 sites in South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest
Evaluation of Effectiveness of Virtual Reality-based Dispatcher Assisted Cardiopulmonary Resuscitation Training
This study aims to compare the effect of conventional cardiopulmonary resuscitation (CPR) training and CPR training with added virtual reality (VR) on trainee self-efficacy.
- Trial name
- NCT06226246
- Testing
- HEROS VR CPR training program, Conventional HEROS CPR training program
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diaphragm Thickness, Dyspnoea
Abdominal Air-Pressure Resistance Versus Abdominal Weight Training for Improving Diaphragm Function in Healthy Young Adults
This study aims to compare the effects of abdominal air pressure resistance training, abdominal weight training, and breathing exercises on diaphragmatic strength, endurance, and physiological responses in young healthy adults.
- Trial name
- NCT07795905
- Testing
- Abdominal Air Pressure Resistance Training, Abdominal Weight Training (AWT), Breathing Exercise Control (BE)
- Where
- United Arab Emirates
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Cardiac Surgical Procedures (Postoperative Population), Critical Illness
BIS in ICU Interventional Study
This study will test whether using a Bispectral Index (BIS) monitor to guide sedation can reduce the amount of sedative medication given to adults in the intensive care unit (ICU) after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures (Postoperative Population), Critical Illness, Postoperative Complications (Cardiopulmonary), Delirium - Postoperative
- Trial name
- NCT07350122
- Testing
- Device-guided sedation, standard sedation practice
- Volunteers
- 144 people
- Sponsor
- Medical University of Graz
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival
A small numbers of patients (10-15%) treated with cardiopulmonary resuscitation (CPR) are discharged from hospitals with a favorable neurologic outcome.
- Trial name
- NCT04009759
- Testing
- Morphine, Ketamine Injectable Solution, Saline 0.9%
- Volunteers
- 240 people
- Sponsor
- University Hospital, Akershus
Pulmonary Hypertension
Continuous Effect Of Rehabilitation Training On Pulmonary Arterial Hypertension Patients
This multicenter, open label, double-arm study aims at investigating the the continuous effect of long-Term rehabilitation training on clinical improvement(ITTCI) and cardiopulmonary function in pulmonary arterial hypertension…
- Trial name
- NCT07149935
- Testing
- Rehabilitation Training
- Where
- China
- Volunteers
- 104 people
- Sponsor
- RenJi Hospital
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load.
- Conditions
- Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction, Right Heart Failure, Acute Cor Pulmonale
- Trial name
- STRAIN (NCT01757522)
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Grenoble
Heart Valve Diseases, Coronary Artery Disease
Performance of the CARDIOGARD Cannula
This is a single center, prospective study: The 'CardioGard Cannula' Gaseous emboli capture results - shows an improvement from the control group.
- Trial name
- GECG (NCT02764645)
- Testing
- CardioGard Cannula, 22Fr curved Cannula
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Obesity, Childhood, Cardiac Disease
Chronotropic Incompetence During Exercise Testing in Obese Adolescents
In adolescents with obesity cardiopulmonary exercise testing (CPET) has become an important clinical examination providing valuable information with regard to the integrative exercise responses, including the pulmonary…
- Conditions
- Obesity, Childhood, Cardiac Disease, Cardiovascular Risk Factor
- Trial name
- NCT04185753
- Testing
- The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Atrial Septal Defect, Ventricular Septal Defects
Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery
The goal of this clinical trial was to compare two settings on a breathing machine used during heart surgery in children. The children in this study were born with a hole inside the heart.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defects, Pulmonary Hypertension, Intracardiac and Septal Defects
- Trial name
- NCT07754591
- Testing
- Pressure Controlled Ventilation, Volume Controlled Ventilation
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Nilratan Sircar Medical College
Atrial Fibrillation
Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis
The goal of this observational study is to learn about the lthe effect of the tetralogy of medication regimen on intraoperative cardioversion in patients with persistent AF.
- Trial name
- NCT06553391
- Testing
- The tetralogy of medication regimen
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction
Chronic Exogenous Ketosis in HFpEF
The goal of this clinical research study is to test what effects a ketone drink will have in people with heart failure with preserved ejection fraction (HFpEF), including on exercise and heart function.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
- Trial name
- NCT06937320
- Testing
- Exogenous Ketone Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
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