Clinical trials: Cardiopulmonary Diseases
Pulmonary Hypertension
Iloprost in High Risk Cardiac Surgical Patients
In this study effects of the intra operative, prophylactic inhalation of Iloprost (Ventavis) before and during extracorporal circulation on perioperative morbidity and outcome in high risk cardiac surgical patients is…
- Trial name
- Ilocard (NCT00927654)
- Testing
- Iloprost (Ventavis)
- Where
- 6 sites in Germany
- Volunteers
- 253 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cardiopulmonary Disease
Indoor Air and Children Health Study
The objective of this study is to investigate the cardiopulmonary health effects of indoor air purification and different indoor environmental factors among school students in Beijing.
- Trial name
- NCT03319056
- Testing
- Air purifier
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Peking University
Congenital Heart Defects
Phase 3 Triiodothyronine Supplementation for Infants After Cardiopulmonary Bypass
This is a study to determine the safety and efficacy of liothyronine sodium/triiodothyronine (Triostat), a synthetic thyroid hormone, when given to infants with congenital heart disease during cardiopulmonary bypass surgery.
- Trial name
- TRICC-2 (NCT02320669)
- Testing
- Triostat
- Where
- 3 sites in United States
- Volunteers
- 220 people
- Sponsor
- Seattle Children's Hospital
Coronary Artery Bypass Surgery, Coronary Heart Disease
An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine)
The purpose of this study is to assess whether nesiritide compared to placebo when given with standard of care therapies, helps preserve kidney function in heart failure (HF) patients undergoing heart bypass graft surgery that…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00530361
- Testing
- Nesiritide
- Sponsor
- Scios, Inc.
Cardiac Arrest, Cardiopulmonary Arrest
NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE)
The NEURESCUE device is the first intelligent catheter for aortic balloon occlusion, an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Cardiovascular Diseases
- Trial name
- ARISE (NCT05444049)
- Testing
- NEURESCUE device
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- neurescue
Cardiopulmonary Resuscitation
Pulse Control Using USG and Manual Palpation Methods in Cardiopulmonary Resuscitation
The final approach adopted in Advanced Cardiac Life Support (ACLS) guidelines as defined by the American Heart Association (AHA) and the European Resuscitation Council (ERC) is to minimize the time between chest compressions in…
- Trial name
- NCT05557032
- Testing
- cardiopulmonary resuscitation
- Where
- Turkey (Türkiye)
- Volunteers
- 536 people
- Sponsor
- Izmir Katip Celebi University
Emphysema, Alveolitis, Fibrosing
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
At present, a specific community based rehabilitation programme for lung or heart-lung transplant recipients does not exist. 160 hospitals throughout the United Kingdom (UK) offer pulmonary rehabilitation programmes.
- Conditions
- Emphysema, Alveolitis, Fibrosing, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT00129350
- Testing
- Pulmonary rehabilitation programme
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Cardiac Disease, Extracorporeal Circulation; Complications
PErfusion QUality ODds
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication after cardiac operations with cardiopulmonary bypass (CPB) use. Its frequency varies depending on the severity grade.
- Conditions
- Cardiac Disease, Extracorporeal Circulation; Complications, Perfusion; Complications, Acute Kidney Injury
- Trial name
- PEQUOD (NCT06019546)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Policlinico S. Donato
Obstructive Sleep Apnea
PAP Therapy Sleep Apnea and Exercise
Positive airway pressure (PAP) therapy is generally offered to patients with obstructive sleep apnea. The investigators suggest that beneficial effects of PAP therapy is by preventing apneas and therefore reducing cardiac and…
- Trial name
- NCT01786291
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Gaziantep
Eccentric Exercise Training
Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD).
- Trial name
- NCT07042750
- Testing
- Eccentric cycling exercise, Standard Care Arm
- Where
- 2 sites in Switzerland
- Volunteers
- 22 people
- Sponsor
- Silvia Ulrich Somaini
Respiratory Tract Diseases, Cardiac Diseases
Cardiopulmonary Effects of Particulate Exposure
The aim of this study is to assess cardiac rate and respiratory responses and rhythm after workplace exposure to combustion particulates.
- Conditions
- Respiratory Tract Diseases, Cardiac Diseases, Bronchitis
- Trial name
- NCT00011310
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Chest Pain, Dyspnea
Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Department
The purpose of the proposed research is to examine whether incorporating point-of-care ultrasound (POCUS) early in diagnostic work-up of cardiopulmonary complaints will affect diagnosis, time to condition-specific intervention…
- Conditions
- Chest Pain, Dyspnea, Syncope, Hypotension
- Trial name
- NCT02861508
- Testing
- Point-of-care ultrasound, Usual care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Yale University
Lung Diseases, Sleep Apnea Syndromes
Regulation of Pharyngeal Muscle Contraction - SCOR in Cardiopulmonary Disorders of Sleep
To determine the degree to which neuro-psychological performance and general health status and function may be impaired in subjects with mild and moderate degrees of sleep-related respiratory disturbances (SRRD), as compared to…
- Trial name
- NCT00005320
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiopulmonary Bypass, Cardiovascular Diseases
Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg.
- Conditions
- Cardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac Surgery
- Trial name
- PANDA (NCT06707350)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Heart Defects, Congenital
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation
Cardiopulmonary bypass and arrest of the heart during cardiac surgery are necessary to allow the surgeon to perform heart operations.
- Trial name
- NCT02519335
- Testing
- Dexrazoxane
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical City Children's Hospital
Coma, Electrographic Status Epilepticus
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest.
- Trial name
- TELSTAR-2 (NCT06549426)
- Testing
- anti-seizure medication + sedative agent(s)
- Where
- 21 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Twente
Cardiopulmonary Resuscitation, Cardiac Arrest
Cardiac Arrest Bundle of cARE Trial
An out-of-hospital cardiac arrest is a sudden event where the heart stops beating and a person becomes unresponsive. During this event, vital organs in the body receive no blood flow, causing them to shut down.
- Conditions
- Cardiopulmonary Resuscitation, Cardiac Arrest, Out of Hospital Cardiac Arrest
- Trial name
- CABARET (NCT05917717)
- Testing
- Neuroprotective 'bundle of care'
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Vasodilatory Hypotension During or After Cardiac Surgery
ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
The purpose of this research is to evaluate the use of Angiotensin II in patients with low blood pressure post-surgery. Your information will be collected for 28 days post the procedure and initiation of the study drug to assess…
- Trial name
- NCT06487585
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland St. Joseph Medical Center
Cardiopulmonary Resuscitation
Prognostic Indicators of Survival Following Cardiopulmonary Resuscitation in Patients With Cardiac Arrest
Cardiopulmonary resuscitation (CPR) occurs approximately 200,000 times/yr in hospitals in the UnitedStates, with 18% of patients surviving to discharge.
- Trial name
- NCT03597425
- Testing
- Cardiopulmonary resuscitation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
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