Clinical trials: Cardiopulmonary Diseases
Gait, Unsteady, Health Behavior
The Effect of a Wearable Hip Assist Robot on Cardiopulmonary Metabolic Efficiency During Stair Ascent in Elderly Adults
The aim of this study was to identify the assistance effect of the new wearable hip assist robot, gait enhancing mechatronic system (GEMS) developed by Samsung Advanced Institute of Technology (Samsung Electronics Co, Ltd.…
- Trial name
- NCT03389165
- Testing
- Wearable hip assist robot
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Samsung Medical Center
Acute Kidney Injury
Bicarbonate in Cardiac Surgery
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- NCT00878956
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 427 people
- Sponsor
- Austin Health
Cancer of Colon, Cancer of Rectum
Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery
To determine whether exercise and nutrition prehabilitation improves patient outcomes after cancer surgery
- Conditions
- Cancer of Colon, Cancer of Rectum, Liver Metastases
- Trial name
- SPECS (NCT04880772)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Atrial Fibrillation
Exercise Performance in Patients With Atrial Fibrillation
Heart failure and stroke are the two major complication of atrial fibrillation. Current treatment for atrial fibrillation is so focused to stroke prevention, but the risk assessment for heart failure is less highlighted.
- Trial name
- AF-CPX (NCT01943981)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Incheon St.Mary's Hospital
Dyspnea, Chronic Obstructive Pulmonary Disease Severe
Alleviating Dyspnea With Non-Invasive Neuromodulation
The goal of this feasibility sham-controlled randomized trial is to assess the feasibility of studying non-invasive neuromodulation techniques, specifically transcutaneous vagal nerve stimulation (tVNS) and transcutaneous…
- Trial name
- PNEURO (NCT06985628)
- Testing
- Transcutaneous vagal nerve stimulation (tVNS), Transcutaneous electrical nerve stimulation (TENS)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Université de Sherbrooke
Pulmonary Arterial Hypertension (PAH)
Telerehabilitation in Pulmonary Arterial Hypertension
Context: Pulmonary arterial hypertension (PAH) causes severe exercise intolerance and reduced quality of life, while access to supervised rehabilitation remains limited.
- Trial name
- TRHP-001 (NCT07799675)
- Testing
- Home-based telerehabilitation program
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cardiac Arrest, Pneumothorax
Post-Resuscitation Pneumothorax - Analysis of Incidence, Risk Factors and Outcome Relevance
In this retrospective study, the investigators seek to investigate the incidence of pneumothorax following possible risk factors, and elucidate its association with outcomes.
- Conditions
- Cardiac Arrest, Pneumothorax, Resuscitation
- Trial name
- NCT06182007
- Testing
- Cardiopulmonary Resuscitation
- Where
- Austria
- Volunteers
- 237 people
- Sponsor
- Auinger, Daniel MD
Household Air Polution, Cardiovascular Diseases
GEOHealth Hub: Household Air Pollution and Cardio-pulmonary and Immune Function Outcomes
Background: The increasing effect of environmental, occupational and climate change poses serious global threat for public health.
- Conditions
- Household Air Polution, Cardiovascular Diseases, Lung Diseases, Immune Dysfunction
- Trial name
- NCT02824237
- Testing
- Improved cook stove
- Where
- Bangladesh
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Cardiovascular Diseases
A Comparison of Conventional Adult Out-of-hospital Cardiopulmonary Resuscitation Against a Concept With Mechanical Chest Compressions and Simultaneous Defibrillation - LINC Study
The primary objective is to show superiority in survival of the modified method with the LUCAS Chest Compression System, compared to the conventional manual resuscitation method in patients suffering from out of hospital sudden…
- Trial name
- LINC (NCT00609778)
- Testing
- LUCAS, Conventional manual resuscitation method
- Where
- 6 sites in Netherlands, Sweden and 1 more
- Volunteers
- 2,500 people
- Sponsor
- Jolife AB
Heart Valve Disease, Coronary Artery Disease
RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery
Heart surgery involving valve replacement often involves the use of the heart-lung machine for over 90 minutes, and bleeding tendency is frequently seen.
- Trial name
- RiaCT (NCT01283321)
- Testing
- Human fibrinogen concentrate, apheresis platelets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Primary Condition/Focus: Cardiopulmonary Resuscitation Training
Simulation-Based CPR Workshop for University Students at Eastern International University
This study aims to evaluate the effectiveness of a simulation-based cardiopulmonary resuscitation (CPR) workshop in improving knowledge, practical skills, attitudes, and self-efficacy among university students at Eastern…
- Trial name
- EIU-CPR (NCT07126808)
- Testing
- Simulation-Based CPR Workshop
- Where
- Vietnam
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Le Hong Liem
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
COPD, Lung Function
Lung Function Decline and Disease Risk From Young Adulthood to Middle Age
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified.
- Conditions
- COPD, Lung Function, Heart - Lung Interaction, Restrictive Lung Disease
- Trial name
- CARDIA Lung (NCT02245178)
- Testing
- Lung spirometry, CT scan analysis
- Volunteers
- 3,193 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Respiration, Artificial, Positive-Pressure Respiration
VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU
Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU).
- Conditions
- Respiration, Artificial, Positive-Pressure Respiration, Postoperative Complications (Cardiopulmonary), Postoperative Complications
- Trial name
- VENTICRIT (NCT07646249)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Stroke, Cardiac Surgery
Effect of Minimally Invasive Extracorporeal Circulation on Optic Nerve Sheath Diameter and Stroke Incidence in Isolated Open Heart Surgery
This prospective randomized controlled trial compares the effects of Minimally Invasive Extracorporeal Circulation (MiECC) versus conventional cardiopulmonary bypass (CPB) on optic nerve sheath diameter (ONSD) and postoperative…
- Conditions
- Stroke, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- ONSD-MiECC (NCT07661238)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Pulmonary Hypertension
Inhaled Milrinone in Cardiac Surgery
The purpose of this study is to investigate the concentration-effect relationship of inhaled milrinone after prophylactic administration in cardiac surgical patients with preoperative pulmonary hypertension undergoing…
- Trial name
- NCT01725776
- Testing
- Inhaled milrinone 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Ventricular Septal Defect
Cardiac Function After Transcatheter VSD Closure
With advances in interventional cardiac catheterization, ventricular septal defect (VSD) could be successfully treated via transcatheter device closure.
- Trial name
- NCT03127748
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
Cardiac Arrest
Non-invasive Neurological Evaluation During CPR
Cardiac arrest remains a leading cause of death, currently affecting >250,000 Europeans outside the hospital each year. Manual cardiopulmonary resuscitation (CPR) provides between 15 to 30 % of normal blood flow to the heart and…
- Trial name
- Neuro-E-CPR (NCT02684955)
- Testing
- Cerebral spectroscopy, Pupillometry
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
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