Clinical trials: Cardiopulmonary Diseases
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Influenza, Human, Transplantation Infection
Standard-dose Versus High-dose Flu Vaccine in Solid Organ Transplant.
Influenza infection in recipients of solid organ transplants recipients while on maintenance immunosuppressant therapy is associated with increased morbidity and mortality.
- Trial name
- NCT01808456
- Testing
- influenza trivalent inactive vaccine, influenza trivalent inactive vaccine high dose
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Inova Health Care Services
Non-Small Cell Lung Cancer
Prospective Study of Quality of Life in Non-small Cell Lung Cancer (NSCLC) Patients Treated With/Without Postoperative Radiotherapy
The patients from 12 centers were included into the study. pN2 patients received PORT, pN1 patients did not. PORT was 3D-planned and consisted in 54-56 Gy in 27-28 fractions.
- Trial name
- NCT01112631
- Where
- Poland
- Volunteers
- 293 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Covid19, Acute Cor Pulmonale
Cardiac Performance in Mechanically Ventilated COVID-19 Patients
Although COVID-19 affects primarily the respiratory system, several studies have shown evidence of cardiovascular alterations. Increased troponin levels were observed in a significant proportion of patients and this alteration…
- Conditions
- Covid19, Acute Cor Pulmonale, Cardiac Failure
- Trial name
- NCT04628195
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
COVID-19
The Effect of Home-based Rehabilitation Program After COVID-19 Infection
To follow up the cardiopulmonary function after coronavirus disease 2019 (CoVID-19) infection and compare the effect of a 12-week home-based cardiopulmonary with or without add-on remote rehabilitation on the cardiopulmonary…
- Trial name
- NCT05317975
- Testing
- Add-on telerehabilitation and home-based rehabilitation, Home-based rehabilitation alone
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Hypertension
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the…
- Trial name
- NCT04901884
- Testing
- PET/MR with 18F-FDG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Simulated Pediatric CRP Ventilation
Simulation-based Comparative Study on Efficiency of Ventilation During Paediatric Cardiopulmonary Resuscitation
The aim of this study is to gather data to support beginning the pediatric cardiopulmonary resuscitation (CPR) with 5 initial breaths.
- Trial name
- PEDIVENT (NCT05345704)
- Testing
- cardiopulmonary resuscitation (CPR)
- Where
- Czechia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Brno University Hospital
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help pediatric patients who have experienced heart failure during surgery and cannot be removed from cardiac…
- Trial name
- NCT01171950
- Testing
- CentriMag Ventricular Assist System
- Sponsor
- Abbott Medical Devices
Coagulopathy, Cardiopulmonary Bypass
Evaluation of TEG 6S PM® During Cardiopulmonary Bypass to Detect Postoperative Biological Coagulopathy
This is a prospective study to evaluate the predictive value of the TEG 6s platelet mapping® (TEG 6s® PM) performed during cardiopulmonary bypass (CPB) in the prediction of biological coagulopathy (determined by TEG 6S global…
- Conditions
- Coagulopathy, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PREDIPOC (NCT06230640)
- Testing
- In vitro medical diagnostic device TEG6s® Platelet Mapping
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Enzyme Replacement Therapy in Pompe Disease
Cardiopulmonary Exercise Test to Quantify Enzyme Replacement Response in Pediatric Pompe Disease
Introduction: Enzyme replacement therapy (ERT) with Myozyme improved the prospect of Pompe disease patients. Our aim was to evaluate ERT acute effect on exercise capacity in pediatric Pompe patients.
- Trial name
- NCT03147664
- Volunteers
- 5 people
- Sponsor
- Rambam Health Care Campus
Ckd-Mbd
Relationship Between Cardiopulmonary Exercise Testing and Ca-P in Chronic Kidney Disease (CKD)
Reductions in exercise capacity associated with exercise intolerance augment cardiovascular disease risk and predict mortality in chronic kidney disease.
- Trial name
- NCT04013139
- Testing
- CPET
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Heart Surgical Procedure
Blood Velocity Variation in Right Renal and Superior Mesenteric Arteries During Cardio-pulmonary Bypass
The cardiopulmonary by-pass technique, used in cardiac surgery to obtain a bloodless operating field and an immobile heart, determines important effects on the blood vessel wall, especially when a continuous and non-continuous…
- Trial name
- NCT06009809
- Testing
- transesophageal echocardiogram
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer, Anaesthesia
Cardiopulmonary Exercise Testing and Preoperative Risk Stratification
The investigators would like to evaluate the use of cardiopulmonary exercise tests (CPX) in guiding the care pathway of patients undergoing colorectal operations.
- Conditions
- Colorectal Cancer, Anaesthesia, Critical Illness
- Trial name
- NCT00737828
- Testing
- Perioperative care pathway guided by CPX results
- Where
- 3 sites in United Kingdom
- Volunteers
- 228 people
- Sponsor
- University College London Hospitals
Mitral Valve Stenosis With Incompetence or Regurgitation
The Effects of Levosimendan During Mitral Valve Surgery
The effects of levosimendan on renal function in patients with low ejection fraction undergoing mitral valve surgery will be investigated in a prospective, double-blinded, randomized clinical trial using serum creatinine…
- Trial name
- NCT01969071
- Testing
- Levosimendan, Dobutamine
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Valve Disease, Heart, CABG
Nonintubated Anesthesia for Adult Cardiac Surgery With Cardiopulmonary Bypass
The goal of this prospective, multicenter, randomized clinical trial is to learn whether a nonintubated supraglottic airway anesthesia strategy with early restoration of spontaneous breathing can reduce postoperative pulmonary…
- Trial name
- NIA-Heart (NCT07744009)
- Testing
- Nonintubated Anesthesia Group, Conventional Anesthesia Group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cardiorespiratory Arrest
Impact of Realistic Simulation Training on Nurses' Cardiopulmonary Resuscitation Performance
Introduction: Cardiopulmonary arrest is one of the most prevalent cardiovascular emergencies worldwide, associated with high morbidity and mortality.
- Trial name
- SIM-CPR Nurses (NCT07623447)
- Testing
- CPR training for nurses with the use of electrical therapy
- Where
- Brazil
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Breast Cancer, HER2-positive Breast Cancer
Study of Cardiopulmonary Exercise Testing in Women Who Have HER2-Positive Breast Cancer With Mild Cardiotoxicity
The purpose of this study is to find out how much oxygen is used during a cardiopulmonary exercise test (CPET) in women who have mild cardiotoxicity after standard treatment for HER2-positive breast cancer, and to see whether the…
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, HER2-positive Metastatic Breast Cancer, Breast Cancer Stage I
- Trial name
- NCT05036252
- Testing
- Cardiopulmonary Exercise Test, Echocardiogram, Echocardiography
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Early Initiation of Extracorporeal Life Support in Refractory OHCA
Despite adequate conventional cardiopulmonary resuscitation (CCPR) and attempted defibrillation, a considerable number of patients in cardiac arrest fail to achieve sustained return of spontaneous circulation.
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Death
- Trial name
- INCEPTION (NCT03101787)
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 10 sites in Netherlands
- Volunteers
- 134 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)
The purpose of this study is to determine whether MC-1 is effective and safe in reducing cardiovascular and neurological events in patients undergoing high-risk coronary artery bypass surgery
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury, Myocardial Revascularization
- Trial name
- NCT00157716
- Testing
- (MC-1) Pyridoxal-5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- Medicure
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