Clinical trials: Cardiopulmonary Diseases
Cardiopulmonary Arrest
SNPeCPR In Cardiac Arrest REsuscitation
Approximately 50,000 patients are victims of out of hospital cardiac arrest every year in France. Despite cardiopulmonary resuscitation (CPR) and many studies on the topic resuscitation survival after cardiac arrest remains low…
- Trial name
- SICARE (NCT02225561)
- Testing
- pharmaco- mechanical optimization, mechanical optimization only
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluid Volume Disorder
Effects of Hypertonic Saline-HES Solution on Extracellular Water in Cardiac Surgery Patients
The aim of the study is to describe the effects of hypertonic saline/hydroxyethylstarch solution in comparison to saline solution for 25 + 25 patients undergoing coronary bypass grafting surgery (CABG) using CPB.
- Trial name
- NCT01348659
- Testing
- 7.2% NaCl/hydroxyethylstarch, NaCl 0.9%
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Kati Järvelä
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Ventricular Septal Defect
Use of Ketamine Prior to Cardiopulmonary Bypass in Children
To assess whether the drug ketamine given prior to cardiopulmonary bypass can decrease injury to the cells in the brain.
- Trial name
- NCT00556361
- Testing
- saline, ketamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Mitral Regurgitation, Pulmonary Hypertension
The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
Mitral regurgitation (MR) is a prevalent valvular heart pathology. Indications for surgery include symptoms, impaired left ventricular function or enlarging dimensions, new onset atrial fibrillation, pulmonary hypertension…
- Trial name
- RIPCOM1 (NCT03155373)
- Testing
- Cardiac catheterisation, Cardiopulmonary exercise testing, Pulmonary function tests
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiac Disease, Renal Disease
Pharmacokinetics of Tranexamic Acid in Patients With Varying Renal Function Undergoing Cardiac Surgery With the Use of Cardiopulmonary Bypass
Cardiopulmonary bypass surgery is associated with extensive blood loss in upto 20% of patients. Tranexamic acid (TXA) is a routinely administered antifibrinolytic agent that reduces blood loss and blood transfusion requirement.
- Trial name
- NCT01609686
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- University Health Network, Toronto
Cardiopulmonary Arrest, VA-ECMO
Optimized CT-imaging Protocol in VA-ECMO Patients After CPR
Veno-arterial (VA) extracorporal membrane oxygenation (ECMO) is an increasingly applied method in patients under cardiopulmonary resuscitation (CPR), who are regularly examined with a contrast-enhanced computed tomography to…
- Trial name
- NCT05290805
- Testing
- ECMO flow rate reduction
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Lung Diseases, Obstructive, Postoperative Complications
Preoperative Self-assessment for Cardio-pulmonary Risk Stratification
This prospective study intends to development and validation a patient self-assessment questionnaire. The aim of the self-assessment, by questionnaire, is to estimate the risk of postoperative pulmonary complications (PPC).
- Conditions
- Lung Diseases, Obstructive, Postoperative Complications, Cardiac Event
- Trial name
- PRESELECT (NCT04156594)
- Where
- Germany
- Volunteers
- 5,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation
Ventilation in Cardiac Arrest Resuscitation Study
Out-of-hospital cardiac arrest (OHCA) is a major public health problem, with around 40,000 victims each year in France. Their survival rate remains dramatically low, at less than 10%.
- Conditions
- Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation, Basic Cardiac Life Support
- Trial name
- VECARS (NCT05992454)
- Testing
- EOLIFE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Defence Health Service
Fontan Palliation, Congenital Heart Disease
Cardio Pulmonary Exercise Testing in Patients Post the Fontan Palliation in Comparison With Patients With Repaired Congenital Heart Disease and Healthy Volunteers.
prospective cardio respiratory evaluation for patients post the Fontan palliation for single ventricle, compared to subjects post successful cardiac repaired surgery compared to healthy volunteers in order to evaluate the…
- Trial name
- NCT02659462
- Testing
- Cardio Pulmonary Exercise Testing
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Heart Failure, Chronic Heart Failure
Wearable Tissue Oximetry During Arm Cuff Occlusion, Walking, and Standing Tests in Outpatients With Chronic Heart Failure
This prospective, single-center, observational pilot study evaluated an investigational wearable tissue oximeter (NIRSense Argus Oximetry System, also called Envello Core) in adult outpatients with chronic heart failure in New…
- Trial name
- NCT07874386
- Testing
- Argus Oximetry System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NIRSense Inc.
Cardiopulmonary Arrest
REBOA in Nontraumatic OHCA
The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients.
- Trial name
- REBOA (NCT06031623)
- Testing
- REBOA
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Seoul National University Hospital
Cardiac Surgical Procedures, Coronary Artery Bypass
Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery
TALEN is a prospective randomised double-blind placebo-controlled phase 2 study of 5-Aminolevulinic Acid with Sodium Ferrous Citrate (5-ALA-SFC) in adult patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Bypass, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- TALEN (NCT07027670)
- Testing
- 5-Aminolevulinic Acid hydrochloride (5-ALA), Sodium ferrous citrate (SFC)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Cardiac Arrest
Endotracheal Intubation Using Three Laryngoscopes in Maternal Cardiac Arrest: a Manikin Simulation Study
European Resuscitation Council (ERC) Guidelines for Resuscitation 2010 emphasize high quality chest compressions .They propose minor changes for pregnant women: manual left deviation of the uterus or a left-lateral incline of…
- Trial name
- NCT02074072
- Testing
- 15 degree left-lateral tilt wedges, 30 degree left-lateral tilt wedges
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hanyang University Seoul Hospital
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia
The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD)…
- Trial name
- NCT07526766
- Testing
- Aerobic and resistance exercises
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Coronary Heart Disease (CHD)
The Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Coronary Heart Disease: A Retrospective Cohort Study(CPETPCAD)
Parameters related to cardiopulmonary exercise testing (CPET) are important objective indicators for evaluating cardiopulmonary function in patients with coronary heart disease.
- Trial name
- CPET-PCHD (NCT07534410)
- Volunteers
- 15,000 people
- Sponsor
- Xinjiang Medical University
Cardiac Arrest, Pediatric ALL
Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN)
: An intrahospital CA data recording protocol has been designed following the Utstein model. Database is hosted according to European legislation regarding patient data protection. It is drafted in English and Spanish.
- Conditions
- Cardiac Arrest, Pediatric ALL, In-hospital Cardiac Arrest
- Trial name
- PACHIN (NCT04675918)
- Testing
- Cardiac arrest
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Jimena del Castillo
Hypogammaglobulinemia, Congenital Heart Disease
Post-bypass Prophylactic IVIG in Infants and Neonates
The purpose of this study protocol is to determine if administering Intravenous Immunoglobulin (IVIG) for treatment of cardiopulmonary bypass (CPB) induced hypogammaglobulinemia in the early post-operative period can impact…
- Trial name
- NCT02043379
- Testing
- IVIG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Stereotype-threat, COVID-19
Stereotype Threat Effect on CPR Performance in Covid-19 Intensive Care Units: A Randomised Controlled Mannequin Study
Stereotype threat (ST) is an important issue that has been studied repeatedly in the psychology literature. ST is the thought that a person will be negatively evaluated and judged regarding a negative stereotype that belongs to…
- Trial name
- NCT05074446
- Testing
- stereotype threat manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
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