Clinical trials: Cardiopulmonary Diseases
Renal Insufficiency, Acute Kidney Injury
Renal Assist Device (RAD) for Patients With Renal Insufficiency Undergoing Cardiac Surgery
The study is a prospective, non-randomized early feasibility study intended to evaluate the safety and performance of the JuxtaFlow System (also known as the JuxtaFlow Renal Assist Device (RAD)) in participants with pre-existing…
- Trial name
- BIPASS-AKI (NCT05990660)
- Testing
- JuxtaFlow System
- Where
- 3 sites in Poland, Serbia
- Volunteers
- 10 people
- Sponsor
- 3ive Labs
Out of Hospital Cardiac Arrest
Continuous Chest Compressions vs AHA Standard CPR of 30:2
The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted…
- Trial name
- CCC (NCT01372748)
- Testing
- Standard CPR, Continuous chest compressions
- Where
- 7 sites in United States, Canada
- Volunteers
- 23,711 people
- Sponsor
- University of Washington
Anderson-Fabry Disease
Functional Capacity in Anderson-Fabry Disease Patients
The goal of this observational study is to observe the relation between excercise parameters - assessed by CPET - and rest/stress hemodynamic parameters - assessed by echocardiogram and CMR - in patients with a genetic diagnosis…
- Trial name
- OPTIMA-FD (NCT06884358)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Neonatal Congenital Heart Disease
Magnetic Resonance Imaging (MRI) to Evaluate Brain Injury in Congenital Heart Disease
Infants with congenital heart disease (CHD) requiring surgery frequently have brain injury seen on magnetic resonance imaging (MRI).
- Trial name
- CHD Brain (NCT00932633)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Emory University
Cardiac Disease, Extracorporeal Circulation; Complications
PErfusion QUality ODds
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication after cardiac operations with cardiopulmonary bypass (CPB) use. Its frequency varies depending on the severity grade.
- Conditions
- Cardiac Disease, Extracorporeal Circulation; Complications, Perfusion; Complications, Acute Kidney Injury
- Trial name
- PEQUOD (NCT06019546)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Policlinico S. Donato
Exercise-Induced Bronchospasm
Effects of Montelukast on Occult Exercise-Induced Bronchospasm in Athletes
The purpose of this study is to determine if treatment of exercise-induced Bronchospasm with montelukast will help college athletes train more effectively and thus become more competitive in a non ergogenic manner.
- Trial name
- NCT00375232
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Hemodynamic Instability, Vasoplegic Syndrome
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement.
- Trial name
- HIPPIE (NCT02675374)
- Testing
- dexchlorpheniramine (Polaramine®) injection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Peripheral Arterial Disease
Cardiopulmonary Exercise Test in Peripheral Arterial Disease
Aim: To determine whether the lactate threshold during CPET is influenced by the presence of haemodynamically significant PAD. Assumption: Correction of haemodynamically significant PAD results in an increased LT, measured by…
- Trial name
- NCT02657278
- Testing
- Arterial Revascularization surgery or Endovascular procedure
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Outpatients, Cardiology
Interpretation Performance in Chinese and Japanese Medical Consultation Scenarios
This study aims to compare the translation and interpretation performance of ChatGPT, Google Translate(GT),and UD Talk in cardiopulmonary consultations and analyze their effectiveness in addressing language barriers.The…
- Conditions
- Outpatients, Cardiology, Pulmonology
- Trial name
- NCT06934031
- Testing
- translation software
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Out-Of-Hospital Cardiac Arrest, Trauma
AI to Improve Outcome From Traumatic Cardiac Arrest
This study evaluates data from patients in The Danish Medical Service electronical registry over a 6-year period from 2016 to 2021 with traumatic cardiac arrest.
- Trial name
- NCT05294575
- Where
- Denmark
- Volunteers
- 31,200 people
- Sponsor
- Prehospital Center, Region Zealand
Heart Failure
High-intensity Interval Versus Combined Exercise Training in CHF
Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and…
- Trial name
- NCT02387411
- Testing
- High-intensity interval exercise training, Combined exercise training
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Athens
Hypertension
Jacobson's Progressive Muscle Relaxation Technique With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals
The study is a randomized controlled trial. The purpose of study is to compare the additive effects of Jacobson's progressive muscle relaxation technique with aerobic exercise versus aerobic exercise on cardiopulmonary parameters…
- Trial name
- NCT06997445
- Testing
- Interventional group: Jacobson's progressive muscle relaxation technique with aerobic exercise, Aerobic Exercise
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Lung Cancer
Cardiopulmonary Monitoring in Lung Cancer Patients Receiving Combined Thoracic Radiotherapy and Immunotherapy
The overall purpose of this study is to evaluate cardiopulmonary toxicity in patients with lung cancer (NSCLC or SCLC) undergoing combined thoracic radiotherapy ± chemotherapy and immunotherapy through timed monitoring and blood…
- Trial name
- NCT06410300
- Testing
- Curative Radiotherapy, Immunotherapy
- Where
- 3 sites in United States
- Volunteers
- 125 people
- Sponsor
- Bo Lu
Obstructive Sleep Apnea of Adult
Effects of Rehabilitation for Patients With Obstructive Sleep Apnea
In previous review study, it was hypothesized that a comprehensive rehabilitation can combine both local pharyngeal muscle exercise and systemic cardiopulmonary rehabilitation for the OSA patients with oropharyngeal muscle…
- Trial name
- NCT03940781
- Testing
- comprehensive rehabilitation
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- National Cheng-Kung University Hospital
Valvular Disease
Impact of Cardiopulmonary Bypass Time on Gastrointestinal Complications
This retrospective study investigates the relationship between cardiopulmonary bypass (CPB) duration and the incidence of gastrointestinal complications (GICs) in patients undergoing heart valve replacement.
- Trial name
- NCT06697405
- Testing
- Prolonged ≥ 120 minutes
- Where
- China
- Volunteers
- 1,444 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Vasoplegic Syndrome
Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass
Several studies have described the use of alternative drugs as methylene blue (MB) (3) other than the standard limited options of the use of vasopressors and systemic corticosteroids (4) especially in the face of increasing…
- Trial name
- NCT06160219
- Testing
- Hydroxycobalamin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Healthy Obesity, Metabolically
Cardio-Pulmonary Exercise Testing in Healthy Population
Introduction: Cardiopulmonary exercise test (CPET) is a helpful tool for evaluation of aerobic exercise capacity and tolerance for variety of population.
- Trial name
- NCT05242211
- Testing
- exercise test
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Acute Kidney Injury, Neurological Injury
Mini Versus Conventional Cardiopulmonary Bypass In CABG in Asian Patients
Our intention is to perform a randomized controlled trial to compare the efficacy and safety of mini cardiopulmonary bypass system to a modified conventional bypass circuit in 80 Asian patients undergoing elective CABG.
- Trial name
- MiniCPB (NCT03657225)
- Testing
- Utilization of the mini CPB circuit, Utilization of the conventional circuit
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
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