Clinical trials: Cardiopulmonary-bypass
Cardiac Surgery
Optimization Strategy for Oxygen Delivery Under Cardiopulmonary Bypass
Cardiac surgery is a frequent procedure that can lead to serious complications, including acute kidney injury (AKI) or postoperative delirium.
- Trial name
- OPTI-DO2 (NCT05984563)
- Testing
- Cardiopulmonary bypass
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Cardiopulmonary Bypass
Validation of Venous Cannulae Flow Ratings
The purpose of this study is to characterize blood flow in the plastic tubing of a heart-lung bypass machine during heart surgery.
- Trial name
- NCT00906906
- Testing
- Doppler probes
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease
Improving the Results of Heart Bypass Surgery Using New Approaches to Surgery and Medication
Surgery for blocked arteries in the heart (coronary artery bypass grafting) can be accomplished using veins from the leg sewn onto the heart to provide an alternate path for blood flow, i.e. 'bypassing' the blockages.
- Trial name
- SUPERIORSVG (NCT01047449)
- Testing
- No-touch SVG harvest vs conventional SVG harvest technique
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre
Atrial Septal Defect, Ventricular Septal Defect
Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol
This clinical trial will determine the safety and effectiveness of intravenous L-citrulline in children undergoing cardiopulmonary bypass during heart surgery.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
- Trial name
- NCT01120964
- Testing
- Intravenous L-Citrulline
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Coronary Atherosclerosis
Potential Effects of Omega 3 Supplementation on Cardiomyocytes Membranes for Patients With Coronary Atherosclerosis?
To show the existence of a atrial cardiomyocytes membranes modification in omega-3 supplemented patients with coronary atherosclerosis.
- Trial name
- CORONOMEGA3 (NCT01699230)
- Testing
- Omega 3
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Surgical Procedure
Impact of HMS Plus Device on Postoperative Blood Loss During Cardiac Surgery
Activated clotting times (ACT) is employed most commonly to assess anticoagulation and ensure adequate heparin and protamine dosing during cardiopulmonary bypass (CPB).
- Trial name
- POC/HMS (NCT03885193)
- Where
- France
- Volunteers
- 188 people
- Sponsor
- Nantes University Hospital
Lung Injury, Cardiopulmonary Bypass
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality.
- Trial name
- NCT04296071
- Testing
- Research study
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sophia Koutsogiannaki
Hypotension During Surgery, Hypotension Postprocedural
Brain Autoregulation Research Study
Randomized, multi-site, study assessing the feasibility of lower limit of autoregulation targeted mean arterial pressure (MAP) vs. standard MAP management in neonates undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT07221721
- Testing
- Surgery with Active MAP Management, Surgery without Active MAP Management
- Where
- United States
- Sponsor
- Jennie E Minnich
Systemic Inflammatory Response, Aortic Valve Stenosis
Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement
Aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.
- Trial name
- NCT05641064
- Testing
- Dexmedetomidine 0.5mcg/kg/h, Dexmedetomidine 1 mcg/kg/h
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Dubrava
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Coronary Artery Bypass Grafting
Arrested Versus Beating Heart Techniques in Coronary Revascularisation
The individual contribution of the specific injuring mechanisms surgical trauma, extracorporeal circulation, and ischemia/reperfusion to clinical outcome in coronary revascularisation remains to be elucidated.
- Trial name
- NCT00999089
- Testing
- Conventional Coronary Artery Bypass, Off-Pump Coronary Artery Bypass, Pump-Assisted Coronary Artery Bypass
- Where
- 2 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Respiratory Failure, Pneumothorax
Mechanical Ventilation During Cardiac Surgery
Background There is no unanimous opinion about a lung-protective strategy in cardiac surgery. Small randomized clinical and animals trials suggest that ventilation during cardio-pulmonary bypass (CPB) could be protective on the…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Aspiration Pneumonia
- Trial name
- NCT02090205
- Testing
- Non-ventilation during CPB, Ventilation with CPAP, Ventilation with 5 act/minute
- Where
- 13 sites in Italy
- Volunteers
- 780 people
- Sponsor
- Ospedale San Raffaele
Patient Undergoing CABG Surgery, Ischemic Heart Disease Patients
Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass
This trial aims to study the performance of CO2 gap, lactate level, and central venous oxygen saturation in predicting major postoperative complications after cardiac surgery with cardiopulmonary bypass
- Trial name
- NCT06839027
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Postoperative Complications
The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index
Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality.
- Trial name
- NCT07044102
- Testing
- Patients Undergoing Low Tidal Volume Ventilation During CABG, Patients Undergoing Apneic Ventilation During CABG
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Atrial Fibrillation, Postoperative Atrial Fibrillation
SGB for Prevention of Postop A-Fib After Cardiac SurgeryTrial
This research study is being conducted to determine whether a stellate ganglion block, a small injection in the neck that temporarily reduces sympathetic nervous system activity, can help reduce the risk of developing…
- Trial name
- NCT07893275
- Testing
- Stellate Ganglion Block Injection with 10 mL 0.5% Bupivacaine, Stellate Ganglion Block Injection with 10 mL Normal Saline
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Bypass, Cardiopulmonary
Menthol Massage for Post-Bypass Pain & Anxiety
This randomized controlled trial aims to evaluate the effectiveness of mentholated ointment massage in reducing pain and anxiety levels in patients who have undergone coronary bypass surgery, volunteered to participate in the…
- Trial name
- Menthol Care (NCT07508371)
- Testing
- Menthol Massage, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
NIR Spectroscopy
Influence of Cardiopulmonary Bypass, and Sevoflurane or Propofol Anesthesia, on Tissue Oxygen Saturation.
The purpose of the present study is to assess, by near infrared spectroscopy with INVOS oximeter during vascular occlusion test (VOT), the influence of cardiopulmonary bypass on tissue saturation in thenar muscle.
- Trial name
- NCT02593448
- Testing
- NIRS during VOT, General anaesthesia with propofol use, General anaesthesia with sevoflurane use
- Where
- Poland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Cerebral Perfusion, Cerebral Oxygenation
Parameters of Cerebral Perfusion
The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of…
- Conditions
- Cerebral Perfusion, Cerebral Oxygenation, Cardiopulmonary Bypass
- Trial name
- NCT02806492
- Testing
- 50-100ug phenylephrine before CPB, 50-100ug phenylephrine during CPB, decreasing CPB flow
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht