Clinical trials: Cardiopulmonary-bypass
Ischemic Heart Disease
Exploration of Cerebral Pathophysiology During and After CABG Using CPB
Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
- Trial name
- NCT02941380
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass
The aim of the planned study is to assess the prophylactic effect of intraoperative administration of a single dose of methylprednisolone 2 (mg/kg) in decreasing the incidence of postoperative acute kidney injury after cardiac…
- Trial name
- NCT06917859
- Testing
- Methylprednisolone group
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Cardiac Surgery
Nicotinamide Mononucleotide in Patients Undergoing Cardiac Surgery
The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective cardiac surgery to investigate the effects of oral nicotinamide mononucleotide (NMN)…
- Trial name
- NCT07013591
- Testing
- MIB-626
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Antithrombinemia
Evaluation of the Relevance of Antithrombin Prescriptions at Strasbourg University Hospitals
Antithrombin (AT) is a physiological inhibitor of the coagulation cascade. In therapeutics, its presence in sufficient quantities is necessary for the pharmacological activity of unfractionated heparin (UFH) and partially…
- Trial name
- EPPATHUS (NCT07276074)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Strasbourg, France
Other Functional Disturbances Following Cardiac Surgery, Memory Disorders
COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-heart Operations
The aim of the study is to prove whether general anesthesia with inhaled sevoflurane reduces the frequency of neurological and cognitive impairment after open-heart operations with use of cardiopulmonary by-pass (CPB) in…
- Trial name
- NCT00541918
- Testing
- Diprivan (propofol, Astra Zeneca), Sevorane (sevoflurane, Abbott)
- Where
- 2 sites in Poland
- Sponsor
- Medical University of Gdansk
Cardiac Surgery Requiring Cardiopulmonary Bypass, Extracorporeal Circulation
Biocompatible Versus Non-coated Extracorporeal Circuits in Cardiac Surgery
The aim of the present strudy is to investigate whether the use of biocompatible extracorporeal circulation circuits with a special hydrophilic polymer coating without heparin causes a reduction in the activation of the…
- Trial name
- BALANCE (NCT06612060)
- Testing
- Cardiac surgery with the use of extracorporeal circulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Polychronis Antonitsis
Pulmonary Hypertension
VentaProst Versus Conventionally-Administered Aerosolized Epoprostenol in Patients Undergoing Cardiac Surgery With CPB
The purpose of the Phase 2a study is to: 1) demonstrate that the estimated VentaProst dose is safe and equivalent in effect to a dose administered via epoprostenol aerosolization by the current off-label-use practice; and 2)…
- Trial name
- NCT03122730
- Testing
- VentaProst
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Aerogen Pharma Limited
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Thoracic Surgery
Albumin Administration and Outcomes in Cardiac Surgery
The invesitgators utilized the Cerner HealthFacts database (a large HIPAA-compliant clinical-administrative database maintained by Cerner Inc., USA) to identify a cohort of 6,249 adults that underwent on-pump cardiac surgery for…
- Trial name
- NCT02878733
- Testing
- Albumin
- Volunteers
- 6,249 people
- Sponsor
- Vanderbilt University
Heart Surgery
Negative Venous Line Pressure in a Miniaturised Cardiopulmonary Bypass Circuit (CPB)
Study to measure the ability of a 'fenestrated' venous line cannula to reduce the negative line pressure seen with kinetic-assist active venous drainage (KAVD) in a standard miniaturised cardiopulmonary bypass circuit and thereby…
- Trial name
- NCT03717649
- Testing
- Conventional 2-stage venous cannula, Conventional 3-stage venous cannula, Fenestrated 3-stage venous cannula
- Volunteers
- 48 people
- Sponsor
- University Hospital Plymouth NHS Trust
Pulmonary Hypertension, Mitral Regurgitation
Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients
Our main hypothesis is that inhalation of milrinone can reduce the elevated pulmonary arterial pressure due to severe mitral valve regurgitation without compromising systemic hemodynamics.
- Trial name
- NCT01621971
- Testing
- inhaled milrinone, intravenous milrinone
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Acquired Antithrombin Deficiency
Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass
The primary objective of this study is to evaluate the efficacy of two different doses of Atenativ, versus placebo, in restoring and maintaining heparin responsiveness in adult patients undergoing cardiac surgery necessitating…
- Trial name
- NCT06096116
- Testing
- Human plasma derived antithrombin
- Where
- 27 sites in United States, Austria and 8 more
- Volunteers
- 120 people
- Sponsor
- Octapharma
NIRS, Cardiac Surgery Associated - Acute Kidney Injury
A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury
Acute kidney injury (AKI) is a complication of cardiac surgery that can affect outcome. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well oxygenated tissues are.
- Conditions
- NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
- Trial name
- NCT06705855
- Testing
- NIRS sensor placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Ischemia-reperfusion Injury
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
Background. Cardiopulmonary bypass in on-pump cardiac surgery (OPCS) can have harmful effects by ischemia-reperfusion. No data about the effects of remote ischemic postconditioning (RIP) in hypoxia-inducible factor-1 alpha…
- Trial name
- NCT04284592
- Testing
- Remote ischemic post-conditioning (RIP)
- Volunteers
- 70 people
- Sponsor
- José García de la Asunción
Complication of Extracorporeal Circulation, Kidney Circulation Disorder
Impact of CArdiopulmonary Bypass Flow on Renal Blood Flow, Function and OXygenation
Cardiac surgery with cardiopulmonary bypass (CPB), especially when oxygen delivery is low, is associated with acute kidney injury.
- Conditions
- Complication of Extracorporeal Circulation, Kidney Circulation Disorder, Renal Function Disorder
- Trial name
- ICAROX (NCT02549066)
- Testing
- Increased cardiopulmonary bypass flow, Milrinone
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Sahlgrenska University Hospital
Cardiac Surgery, Cardiopulmonary Bypass
REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
- Trial name
- RETROCAR (NCT04979754)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Bypass Grafting
Complement Activation and Central Nervous System Injury After Coronary Artery Surgery
The impact of the postoperative inflammatory response on the central nervous system after cardiac surgery is uncertain. The goal of this study was to evaluate the role of complement activation on cellular brain injury and…
- Trial name
- NCT00188006
- Testing
- heparin-coated cardiopulmonary bypass
- Sponsor
- University Hospital, Angers
Mitral Valvular Heart Disease
Comparison of 6% Hydroxyethyl Starch 130/0.4 With 5% Albumin as Priming Solution for Cardiopulmonary Bypass
Comparison of 6% hydroxyethyl starch 130/0.4 with 5% albumin as priming solution for cardiopulmonary bypass
- Trial name
- NCT00978588
- Testing
- 6% hydroxyethyl starch 130/0.4 and 5% albumin
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Acute Kidney Injury
Bicarbonate in Cardiac Surgery
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- NCT00878956
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 427 people
- Sponsor
- Austin Health