Clinical trials: Cardiopulmonary-bypass
Cardiopulmonary Bypass, Lactate
Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries
Tissue hypoperfusion during cardiopulmonary bypass (CPB) affects cardiac surgical outcomes. Lactate, an end product of anaerobic glycolysis from oxygen deficit, is an obtainable marker of tissue hypoxia.
- Trial name
- NCT03934892
- Testing
- serum lactate
- Volunteers
- 97 people
- Sponsor
- Hualien Tzu Chi General Hospital
Congenital Heart Disease
The Myocardial Protective Effects of a Moderate-potassium Blood Cardioplegia in Pediatric Cardiac Surgery
The investigators previously investigated the cardioprotective effect of an adenosine-lidocaine cardioplegia with moderate-potassium (K+, 10.0 mmol/L) in pediatric cardiac surgery, which was associated with better myocardial…
- Trial name
- NCT01479049
- Testing
- MP (moderate potassium) group, HP (High potassium) group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Anesthetics, Intravenous, Pharmacology
Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass
Target controlled infusion with remifentanil is widely used during cardiac surgery, wich is performed using the Minto model. It was derived from patients undergoing general surgery.
- Conditions
- Anesthetics, Intravenous, Pharmacology, Anesthetics, Cardiopulmonary Bypass
- Trial name
- NCT02566733
- Testing
- Remiva, Ultiva
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Seoul National University Hospital
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help patients who have experienced heart failure during surgery and cannot be removed from cardiac bypass.
- Trial name
- NCT00819793
- Testing
- CentriMag Ventricular Assist System
- Where
- 14 sites in United States
- Volunteers
- 32 people
- Sponsor
- Abbott Medical Devices
Laryngoscopy, Hemodynamic Changes
Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG…
- Trial name
- NCT07435337
- Testing
- Nalbuphine, Fentanyl
- Where
- Pakistan
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Institute of Cardiology
Cardiopulmonary Bypass, Consciousness Monitors
Isoflurane During Cardiopulmonary Bypass
There is no clinical way of assessing the depth of anaesthesia while patients are on the heart-lung machine. A new method of measuring the depth of anaesthesia using brainwaves called the Bispectral index (BIS) has been developed…
- Conditions
- Cardiopulmonary Bypass, Consciousness Monitors, Isoflurane
- Trial name
- NCT02471950
- Testing
- 2.5 % Isoflurane administration
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Ventricular Septal Defect
Use of Ketamine Prior to Cardiopulmonary Bypass in Children
To assess whether the drug ketamine given prior to cardiopulmonary bypass can decrease injury to the cells in the brain.
- Trial name
- NCT00556361
- Testing
- saline, ketamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Emergence Delirium, Postoperative Delirium
Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With Perioperative Use of a Heart-lung Machine; a Monocentric Pilot Observational Study
Basics (state of scientific knowledge): Delirium is an acute disturbance of consciousness and attention that develops over a short period of time and fluctuates in severity.
- Trial name
- MO-FA2-(TB) (NCT07276503)
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Heart Valve Surgery
Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
- Trial name
- NCT05136001
- Testing
- polysomnography
- Where
- China
- Volunteers
- 36 people
- Sponsor
- China Medical University, China
Cognitive Decline
Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass
The incidence of cognitive decline related to CPB ranges from 20% to 80%, which may affect length of hospital stay, quality of life, the rehabilitation process, and work performance.However, there is no method to prevent the…
- Trial name
- NCT00297245
- Testing
- cognitive function
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Heart; Dysfunction Postoperative, Cardiac Surgery
Clinical Assessment of Nonin 7600 Near Infrared Spectroscopy (NIRS) Tissue Oximetry During Cardiovascular Surgery
An observational study designed to evaluate the performance of a new Near Infrared Spectroscopy (NIRS) tissue oximeter device in the clinical setting, including a cerebral sensor and peripheral sensor.
- Trial name
- NCT01289470
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nonin Medical, Inc
Cardiovascular Surgery, Blood Loss, Surgical
Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil
Randomized trial to evaluate the effectiveness of a intra operative blood recovery system in reducing the need for allogeneic transfusion in cardiovascular surgeries using cardiopulmonary bypass
- Trial name
- NCT06601582
- Testing
- Use of a operative blood salvage system
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Complex Congenital Heart Disease
Noninvasive Measurement of the Cerebral Autoregulation in Neonates and Infants With Complex Congenital Heart Disease
Feasibility of non-invasive cerebral autoregulation measurement at the PICU and impact of changes in oxygen supply
- Trial name
- NCT04810013
- Testing
- non-invasive measurement of cerebral autoregulation
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Tuebingen
Vasodilatory Hypotension During or After Cardiac Surgery
ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
The purpose of this research is to evaluate the use of Angiotensin II in patients with low blood pressure post-surgery. Your information will be collected for 28 days post the procedure and initiation of the study drug to assess…
- Trial name
- NCT06487585
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland St. Joseph Medical Center
Congenital Heart Disease
Study of Possible Brain Hormone Problems After Open Heart Surgery in Infants
The goal of this study is to evaluate specific hormone levels in children undergoing heart surgery in order to identify patterns associated with any unstable vital signs.
- Trial name
- NCT00850720
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Congenital Heart Disease, Disorder of Fetus or Newborn
Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition…
- Trial name
- NCT01579513
- Testing
- Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Medical University of South Carolina
Cardiopulmonary Bypass, Cardiac Surgery
Prediction of PPC Using DAMPs in Adult Cardiac Surgery
DAMPs (damage associated molecular patterns) are endogenous molecules that are expressed by cell stress or cell damage and play an important role in tissue (or host) defense and repair by activating the innate immune system.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Damage-associated Molecular Patterns
- Trial name
- NCT04945915
- Testing
- blood sampling
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Pusan National University Yangsan Hospital
Intraoperative Hypotension
Bispectral Index Guided Sevoflurane Titration
Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates. The investigators hypothesised that goal-directed sevoflurane administration (guided by BIS monitoring)…
- Trial name
- NCT02515019
- Testing
- Bispectral index Monitoring
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures
Electroacupuncture at ST36 for Reducing Postoperative Inflammation After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery using cardiopulmonary bypass can trigger a marked systemic inflammatory response and may contribute to postoperative organ dysfunction and delayed recovery.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures, Postoperative Complications (Cardiopulmonary)
- Trial name
- EAST36-CPB (NCT07795112)
- Testing
- Electroacupuncture at Bilateral ST36, Acupuncture Without Electrical Stimulation at Bilateral ST36
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital