Clinical trials: Cardiosurgery
Cardiosurgery, Cardiopulmonary Bypass
Methadone in Adults Undergoing Cardiac Surgery
In cardiac surgery, the establishment of Cardiopulmonary bypass (CPB) involves profound changes that can alter the pharmacokinetics and clinical response to drugs.
- Conditions
- Cardiosurgery, Cardiopulmonary Bypass, Methadone
- Trial name
- NCT05075265
- Testing
- Methadone
- Where
- Chile
- Volunteers
- 29 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Shock, Cardiogenic, Shock Hypovolemic
Clinical Validation of Algorithms for Mean Systemic Filling Pressure and Automated Cardiac Output
Prospective combined clinical validation of an algorithmic calculated mean systemic filling pressure (Pms-Nav) with the gold standard for Pms (Pms calculated from venous return curves during inspiratory hold procedures with…
- Conditions
- Shock, Cardiogenic, Shock Hypovolemic, Hypovolemia, Cardiac Failure
- Trial name
- PP3D (NCT04202432)
- Testing
- Mean systemic filling pressure
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Postoperative Complications
Cardiopulmonary Exercise Testing in Cardiosurgery Patients
Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery.
- Trial name
- NCT06702059
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in Czechia
- Volunteers
- 130 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Congenital Heart Disease, Mechanical Ventilation Complication
Mechanical Ventilation During Cardiopulmonary Bypass
The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs
- Conditions
- Congenital Heart Disease, Mechanical Ventilation Complication, Cardiopulmonary Bypass
- Trial name
- VENICE (NCT03629574)
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Padova
Continuous Lactate Measurements, Cardiosurgery
Lactate in High-risk Cardiac Surgery
The major combined interventions are between challenging and high-risk aspects of current cardiosurgical practice. The results of operation may be hampered by unexpected anatomic and technical features influencing the surgical…
- Trial name
- CLM-CARD (NCT02568969)
- Testing
- Eirus continuous lactate monitor
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Northern State Medical University
Postoperative Heart Insufficiency
EVENT - Evaluation of the Influence of hTEE
Compromised tissue oxygenation during surgery may negatively influence patient outcome. Primary cause of insufficient tissue oxygenation is reduced cardiac output due to hypovolemia and/or reduced cardiac contractility.
- Trial name
- EVENT (NCT02046954)
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Charite University, Berlin, Germany
Atrial Fibrillation
CArdioSurgEry Atrial Fibrillation Register
CASE AF aims to describe the reality of medical care of patients in whom atrial fibrillation is treated by cardiac surgical ablation.
- Trial name
- CASE-AF (NCT03091452)
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Cardiosurgery
The Kallikrein-Kinin System in Cardiac Surgery
We aimed to established an interlink among the kallikrein-kinin system (KKS), endothelial dysfunction and POD in response to cardiosurgery , using clinic investigation.
- Trial name
- NCT06080295
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Qin Zhang
Death
Virtual Autopsy in Cardiology, Cardio- and Vascular-Surgery
Today complex vascular and cardiological interventions are performed in severely ill patients. Autopsy is the reference standard for quality control for almost two centuries, but autopsy rates for patients dying in hospitals are…
- Trial name
- NCT02502955
- Testing
- Comparison autopsy methods
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rheumatic Heart Disease, Coronary Heart Disease
Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery
In view of the lack of large-scale clinical study and potent evidence-based medicine, the investigators designed a randomized, double-blind, placebo-controlled study to ascertain whether preoperative intravenous administration…
- Trial name
- NCT01794884
- Testing
- Glutamine, Ringer's solution
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yuejiang Liu
Congenital Heart Disease in Children, Cardiopulmonary Bypass
Acute Kidney Injury in Children After Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common complication in patients with congenital heart defects after cardiopulmonary bypass. The death rate from AKI in critically ill children remains high and reaches 60%.
- Trial name
- NCT03144011
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Kidney Injury, Renal Replacement Therapy
AKI Cardiosurgery Diagnostic Study (AKI-CDS)
Acute kidney injury (AKI) is a common and major complication of cardiac surgery. The aim of this study is to evaluate the use of a fragment of proencephalin in plasma and other biomarkers as specific markers for early diagnosis…
- Trial name
- AKI-CDS (NCT03632538)
- Testing
- Biomarker ("penKid", adrenomedulin, C-terminal alpha-1 antitrypsin peptide)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock