Clinical trials: Cardiothoracic Surgery
Acute Renal Failure, Acute Kidney Injury
Pre-operative Short-term Administration of a Formula Diet Containing a Non-milk-derived Protein Source for Prevention of Acute Kidney Injury After Cardiac Surgery
Cardiac surgery is associated with a high risk of postoperative AKI with significant morbidity and mortality. To date, no preventive or therapeutic measures exist to prevent this.
- Trial name
- UNICORN (NCT03715868)
- Testing
- Non-milked derived protein source formula diet
- Where
- Germany
- Volunteers
- 117 people
- Sponsor
- University of Cologne
Acute Renal Failure
Brief Title:Effect of a Preoperative Calorie Restriction on Renal Function After Cardiac Surgery
The aim of this study is to assess the effect of a diet prior to cardiac surgery on the common postoperative decline of renal function. Until now, there is no known drug or procedure to preserve the kidneys from this impairment.
- Trial name
- CR_KCH (NCT01534364)
- Testing
- calorie restriction
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- University of Cologne
Postoperative Pain, Anxiety Postoperative
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benzodiazepines, which can have…
- Conditions
- Postoperative Pain, Anxiety Postoperative, Opioid Use
- Trial name
- NCT04912531
- Testing
- Virtual Realty using a Microsoft Hololens, Empatica HR wristband, and EEG, Essence Olfactory Necklace, Bedside Olfaction Device
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Critical Illness, Enteral Feeding
Tolerance and Efficacy of a Predigested, High Protein, High Omega 3 Fat Enteral Feeding Formula Versus a Standard Formula In Multiple Intensive Care Unit Settings
The purpose of this pilot study is to assess the efficacy, safety and tolerance profile of the enteral feeding product VITAL AF (a semi-elemental, high protein, and high omega-3 fish oil) when compared to Osmolite 1.2, a standard…
- Trial name
- NCT01448135
- Testing
- VITAL AF, Osmolite 1.2
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Pediatric Patients After Cardiothoracic Surgery
High Flow Nasal Cannula in Pediatric Patients After Cardiothoracic Surgery
High flow nasal cannula(HFNC) ventilation can provide such effects as wash-out effect of the carbon dioxide inside the anatomical dead space,some level of continuous airway pressure and humidified oxygen gases.
- Trial name
- OSACA CATS (NCT04451057)
- Testing
- high flow nasal cannula therapy, low flow nasal cannula therapy
- Where
- Japan
- Volunteers
- 286 people
- Sponsor
- Osaka University
Cardiothoracic Surgery, Vascular Surgery
A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery
This study will evaluate the safety and efficacy of ABT-719 in patients undergoing high risk major surgery.
- Trial name
- NCT01897519
- Testing
- ABT-719
- Where
- 23 sites in United States, Denmark
- Volunteers
- 56 people
- Sponsor
- AbbVie
Cardiac Disease, Surgery
Patient-centered and Clinical Outcomes After Minimally Invasive Cardiothoracic Surgery
Nowadays, minimally invasive cardiothoracic surgery techniques are being performed to treat patients with coronary heart diseases.
- Trial name
- NCT03902717
- Testing
- Minimally invasive cardiac surgery
- Where
- 2 sites in Belgium
- Volunteers
- 209 people
- Sponsor
- Jessa Hospital
Chylous Pleural Effusion Following Cardiothoracic Surgery
Fortified Skimmed Mother's Milk in the Management of Chylothorax
The purpose of this study is to determine if the use of fortified skimmed mother's milk is a safe alternative to specialized formula in the treatment of chylothorax following cardiothoracic surgery.
- Trial name
- NCT01673165
- Testing
- Skimmed mother's milk, Specialized Formula
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Bleeding Active
Effectiveness and Safety of CELSTAT for Hemostasis in Intraoperative Tissue Bleeding
The study is to evaluate the effectiveness and safety of CELSTAT vs active control.
- Trial name
- CELSTAT (NCT02640235)
- Testing
- CELSTAT, Surgicel Original
- Where
- 25 sites in United States, Czechia and 2 more
- Volunteers
- 260 people
- Sponsor
- Baxter Healthcare Corporation
Diabetes
Real-time Continuous Glucose Monitoring in Diabetic Cardiothoracic Surgery Patients
An increased risk of adverse outcome is noted for diabetic patients admitted in surgery intensive care units (ICU). Tight glycemic control with intensive insulin therapy dramatically reduces in-hospital mortality and adverse…
- Trial name
- MARGE (NCT00878891)
- Testing
- Continuous glucose monitoring for immediate correction of abnormal glycemia
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Bordeaux
Diabetes Mellitus
Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir
In this study we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir).
- Trial name
- NCT00717288
- Testing
- Detemir
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Ohio State University
Coronary Artery Atherosclerosis
Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery
Patients undergoing cardiac surgery frequently develop neurologic complications, ranging from subtle cognitive changes to evident confusion, delirium, and stroke.
- Trial name
- NCT01310608
- Testing
- A-View
- Volunteers
- 32 people
- Sponsor
- Isala
Shock
Renin as a Biomarker of Haemodynamic Normalisation
Study design Observational, single centre, prospective cohort study Planned sample size 100 participants Inclusion criteria The study will evaluate a cohort of participants meeting the following inclusion criteria: 1.
- Trial name
- NCT04303455
- Testing
- blood sampling
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- South West Sydney Local Health District
Cardiac Surgery Intensive Care Treatment
Identification of Dominate Stressors in the Intensive Care Unit (ICU)
Undergoing cardiopulmonary bypass surgery and the subsequent admission to the intensive care unit (ICU) is known to be a stressful event to the patient.
- Trial name
- NCT00645008
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Weill Medical College of Cornell University
Respiratory Insufficiency
BIPAP Vision Versus OPTIFLOW System Comparison in Acute Respiratory Failure After Cardio Thoracic Surgery
The OPTIFLOW ™ use is becoming more common in acute respiratory failure cases, but its place in relation to VNI (Bi-PAP mode) is not yet defined.
- Trial name
- OPTIFLOW (NCT01458444)
- Testing
- Non invasive ventilation (VNI), Non invasive ventilation
- Where
- France
- Volunteers
- 830 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Coronary Artery Bypass Grafting
Effectiveness of BoneSeal® on Bone Hemostats in Patients Undergoing Cardiothoracic Surgery
A prospective randomized open-label study that will evaluate the effectiveness of the pliable and absorbable bone hemostats (BoneSeal®) on the reduction of bleeding from the sternal bone marrow in patients undergoing…
- Trial name
- NCT03085017
- Testing
- BoneSeal, Ostene
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Loma Linda University
Cryotherapy Effect, Post Operative Pain
Cryoanalgesia and Post-thoracotomy Pain in Minimally Invasive Cardiothoracic Surgery
Minimally invasive cardiothoracic surgery is often associated with chronic pain syndrome, out of keeping with the extent of surgical dissection.
- Trial name
- NCT05255146
- Testing
- Atricure Inc. Nitrous oxide Cryoprobe
- Sponsor
- University of Alberta
Postoperative Atrial Fibrillation
Microvascular Effects of Intravenous Esmolol During Postoperative Atrial Fibrillation
Background: Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy by using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic…
- Trial name
- FANI (NCT03646773)
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
AKI - Acute Kidney Injury, Cardiac Surgery
Urine Output Response to Fluid and Diuretic Therapy in Cardiac ICU Patients Monitored With FIZE kUO®
This prospective observational study evaluates the real-time urine output response to fluid therapy and diuretics in cardiothoracic intensive care unit (CTICU) patients monitored with the FIZE kUO® device.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgery, Fluid Therapy, Hemodynamic Instability
- Trial name
- NCT07022314
- Testing
- FIZE kUO®
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- FIZE Medical ltd
Mechanical Ventilation
RespirAq Humidifier Usability During Invasive Ventilation
This study aims to capture preliminary safety and effectiveness information on a near-final humidifier device design and to provide data for more extensive research, if required.
- Trial name
- NCT04765878
- Testing
- RespirAq Humidification
- Volunteers
- 20 people
- Sponsor
- Auckland University of Technology