Clinical trials: Cardiothoracic Surgery
Cardiothoracic Surgery
Clinical Study Evaluating the Performance of HEMOBLAST Bellows Compared to FLOSEAL Hemostatic Matrix in Cardiothoracic Operations
The purpose of this study is to evaluate the performance of HEMOBLAST™ compared to FLOSEAL in cardiothoracic operations.
- Trial name
- NCT03725098
- Testing
- HEMOBLAST Bellows, FLOSEAL
- Where
- 4 sites in United States
- Volunteers
- 105 people
- Sponsor
- Biom'Up France SAS
IHD, Valve Heart Disease
Role of Chest Ultrasound in Detection of Post-operative Pulmonary Complications After Cardiothoracic Surgery
assess feasibility of detecting pulmonary complications postoperative using chest ultrasound compared to chest x-ray measure time lag between using ultrasound and using chest x-ray to detect pulmonary complications postoperative
- Conditions
- IHD, Valve Heart Disease, Surgery--Complications
- Trial name
- NCT04118621
- Testing
- chest ultrasound
- Volunteers
- 100 people
- Sponsor
- Assiut University
Vasoplegia, Vasoplegic Shock
Endotoxinemia and Vasoplegia Following Cardiothoracic Surgery With Cardiopulmonary Bypass (CPB)
This observational study investigates the effect of endotoxinemia on the postoperative incidence of vasoplegia or vasoplegic shock in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.
- Trial name
- NCT05925348
- Testing
- Patients with cardiopulmonary bypass
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universität Münster
Chronic Pain, Thoracic
Chronic Pain After Cardiothoracic Surgery
This is a prospective cohort study to estimate prevalence of chronic pain after cardiothoracic surgery
- Conditions
- Chronic Pain, Thoracic, Chronic Pain Syndrome
- Trial name
- NCT05702125
- Volunteers
- 96 people
- Sponsor
- Universitas Indonesia
Congenital Heart Disease
Post-Op Massage in Infants With Congenital Heart Disease
The primary aims of the proposed study are to pilot test the effectiveness of daily massage on pain and clinical outcomes in infants who have undergone cardiothoracic surgery.
- Trial name
- NCT04416230
- Testing
- massage, quiet time
- Volunteers
- 65 people
- Sponsor
- Ohio State University
Cardiothoracic Surgery
Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery
Evaluation of Liposomal Bupivacaine Compared to Usual Care and its Effect on Pain for Cardiac Surgery
- Trial name
- EXPAREL (NCT04065919)
- Testing
- Liposomal bupivacaine, 0.25% Bupivacaine with epinephrine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Florida Heart and Lung Institute
Cardiac Surgery, Inflammation
Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation
The purpose of this study is to see if ascorbic acid (Vitamin-C) therapy will reduce inflammation following heart surgery.
- Trial name
- AFIST (NCT00519337)
- Testing
- Ascorbic acid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hartford Hospital
Patient With Clinically Indicated Invasive Monitoring
ClearSight System CHN Study
The purpose of this clinical trial is to demonstrate that cardiac output (CO) as determined with the Clinical Platform (Model:EV1000A, Software Version:1.9) in a noninvasive manner is comparable to CO as determined by Pulmonary…
- Trial name
- NCT03807622
- Testing
- EV1000NI Clinical Platform: Noninvasive Hemodynamic Monitoring utilizing ClearSight System
- Where
- 3 sites in China
- Volunteers
- 125 people
- Sponsor
- Edwards Lifesciences
Cardiothoracic Surgery, Post-operative Atrial Fibrillation
Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)
This study will compare the effects of 20 mg of atorvastatin to 80 mg of atorvastatin for the prevention of atrial fibrillation after cardiothoracic surgery.
- Trial name
- NCT02029534
- Testing
- Atorvastatin 20 mg, Atorvastatin 80 mg
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Creighton University
Post-Operative Delirium
A Study to Evaluate ICU Simulation Experience in the Cardiothoracic Surgical Population to Reduce Post-operative Delirium
The purpose of this study is to evaluate the effect of a pre-ICU admission virtual reality ICU simulation on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.
- Trial name
- NCT05159648
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Mayo Clinic
Thoracic Diseases, Cardiovascular Diseases
Respiratory-Swallow Coordination in Cardiothoracic Surgical Patients
Dysphagia (swallowing impairment) is a common complication of cardiothoracic surgery (CS). Although alterations in respiratory-swallow coordination is a known underlying pathophysiologic mechanism of dysphagia in multiple patient…
- Trial name
- NCT05173207
- Testing
- Videofluoroscopic swallow exam with concurrent monitoring of respiratory-swallow coordination
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Frailty, Anesthesia
Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observational Study
Frailty is a multidimensional syndrome characterized by a decline in physiological homeostatic reserve, which translates into an increased susceptibility to adverse events and unfavorable outcomes following even small exposures…
- Conditions
- Frailty, Anesthesia, Thoracic Surgery, Cardiothoracic Surgery
- Trial name
- CAfCA (NCT05968456)
- Testing
- Data collection
- Where
- 8 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Postoperative Respiratory Complication
Preoperative Self-managed Respiratory Therapy for Reduction of Postoperative Pulmonary Complications
Postoperative pulmonary complications (PPCs) are a source of much morbidity and mortality. Rates of PPCs exceed 30% in patients with multiple risk factors.
- Trial name
- PRESMART (NCT03356496)
- Testing
- AirLife 4000 cc incentive spirometry device
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery
Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery
Frail Veterans are at increased risk for poor surgical outcomes, and as the Veteran population grows older and more frail, there is a critical need to identify effective strategies for reducing surgical risks for these patients.
- Conditions
- Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery, Frailty
- Trial name
- NCT03299101
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Office of Research and Development
Post Operative Pain
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
This is a retrospective and prospective, multicenter, observational patient registry to record outcomes from patients undergoing cryoablation of the intercostal nerves (cryoanalgesia) for post-operative pain management.
- Trial name
- REDUCE (NCT05110989)
- Testing
- AtriCure Cryo Nerve Block (cryoNB) Device Family
- Where
- 11 sites in United States, Austria and 3 more
- Volunteers
- 5,000 people
- Sponsor
- AtriCure, Inc.
Depression
Depression Among Cardiothoracic Surgery Patients in Baghdad
This observational study aims to estimate the prevalence and severity of depression among patients in the Cardiothoracic Surgery Ward in Baghdad City, Iraq, using a self-administered PHQ-9 questionnaire.
- Trial name
- PHQ-9 (NCT06734169)
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Al-Nahrain University
Staphylococcus Aureus, Bacteremia
Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
This study will assess the efficacy of a single dose of V710 vaccine to prevent serious Staphylococcus aureus infections following elective cardiothoracic surgery.
- Conditions
- Staphylococcus Aureus, Bacteremia, Mediastinitis
- Trial name
- NCT00518687
- Testing
- V710
- Volunteers
- 8,031 people
- Sponsor
- Merck Sharp & Dohme LLC
Chylothorax
Dietary Treatment of Infants With Chylothorax
Chylothorax occurs in ~3 to 5 % of infants undergoing cardiac surgery. Standard treatment requires discontinuation of breast milk feeding, due to the abundance of long chain triglycerides, and transition to a medium chain…
- Trial name
- NCT02143557
- Testing
- Fat-Modified Breast Milk, MCT formula
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Neuromuscular Block, Residual
Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery
The purpose of this study is to assess the effect of quantitative block monitoring versus less expensive qualitative monitoring treatment effects on the lowest SpO2/FiO2 ratio in the PACU.
- Trial name
- QUANTUM (NCT07084363)
- Testing
- Quantitative monitoring, Qualitative monitoring
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- The University of Texas Health Science Center, Houston
Deep Venous Thrombosis
Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery
A blood clot in the veins, also known as deep venous thrombosis (DVT), is one of the most common complications after surgery. This may result in death if a clot breaks off and travel to the lungs; this is referred to as pulmonary…
- Trial name
- NCT00329433
- Testing
- Desirudin (Iprivask™), Heparin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Washington University School of Medicine