Clinical trials: Cardiovascular
Myocarditis, Takotsubo Cardiomyopathy
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)
Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues.
- Conditions
- Myocarditis, Takotsubo Cardiomyopathy, Reversible Coronary Ischaemia
- Trial name
- MEMORY (NCT04623788)
- Testing
- Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Lumbar Spinal Stenosis, Cardiac Amyloidosis
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective.
- Conditions
- Lumbar Spinal Stenosis, Cardiac Amyloidosis, ATTR Amyloidosis Wild Type, ATTR Gene Mutation
- Trial name
- NCT06034405
- Testing
- Tc99-PYP or Tc99-HDMP Scan
- Where
- 6 sites in United States
- Volunteers
- 1,663 people, healthy volunteers welcome
- Sponsor
- Columbia University
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension
Clinical Study of Blood Pressure Monitor in Conformance With the ANSI/AAMI SP10
The clinical protocol of the clinical testing of this device: 1. Objective of the test: To verify the function of device. 2. Test methods and procedures: Performance test in two positions: Seated and Supine. 3.
- Trial name
- BPM_S (NCT01502553)
- Testing
- Comparison Test to Yuyue Medical BP Meter, YYBP-212
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Leo Wang
Cardiovascular Diseases, Stress, Psychological
Adaptive Internet-based Stress Management Among Adults With a Cardiovascular Disease: A Pilot Sequential Multiple Assignment Randomized Trial (SMART) Design
Internet-based stress management programs adapted to patients' needs Stress is inevitable, and it has many negative consequences on the health of everybody, but particularly on the health of patients with a cardiovascular disease…
- Trial name
- NCT03267953
- Testing
- My Health CheckUp Online Stress Management Program, Lay telephone coaching, Motivational interviewing (telephone)
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Stroke, Urinary Incontinence
Effect of Pelvic Floor Muscle Training in Stroke
Aim: To evaluate the long term effect of pelvic floor muscle training in women with urinary incontinence after ischemic stroke measured by quality of life paramters.
- Trial name
- NCT00258037
- Testing
- Pelvic Floor Muscle training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-1 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421388
- Testing
- BR1015-A, BR1015-1, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Chronic Wounds, Burns
THERAVEX Tissue Care Spray Plus for the Management of Cutaneous Wounds, Burns, and Chronic Ulcers
Pilot observational clinical evaluation assessing the safety and potential effectiveness of THERAVEX Tissue Care Spray Plus as an adjunctive topical therapy for the management of cutaneous wounds, burns, traumatic lesions…
- Conditions
- Chronic Wounds, Burns, Pressure Ulcer, Traumatic Wounds
- Trial name
- NCT07617961
- Testing
- THERAVEX TISSUE CARE SPRAY PLUS
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Biointelligent Technology Systems SL
Dilated Cardiomyopathy
Pathophysiology of Dilated Cardiomyopathy
This will be a cross-sectional, observational study. Null hypothesis: There is no difference in the amount of extracellular volume (ECV or scarring) in the hearts of patients with heart failure as compared to control subjects.
- Trial name
- NCT02001961
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Chronic Kidney Diseases, Cardiovascular Diseases
Assessment of Protein Modification in Chronic Kidney Disease - Selected Clinical and Biochemical Aspects
The studies included the effect of chronic kidney disease advancement on the accumulation of oxidative stress markers in plasma. In patients with end-stage renal disease, the effect of replacement therapy was also assessed.
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Dialysis; Complications
- Trial name
- NCT04939870
- Testing
- Biochemical parameters evaluation
- Where
- Poland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Cardiovascular Disease, Stroke
Heart Outcomes Prevention Evaluation-3
Heart disease and stroke are major causes of death and disability worldwide and are largely preventable. Cholesterol and blood pressure are major cardiovascular risk factors.
- Trial name
- HOPE-3 (NCT00468923)
- Testing
- Candesartan/HCT, Rosuvastatin
- Where
- Canada
- Volunteers
- 12,705 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Coronary Artery Disease (CAD), Cardiac Rehab
The Effect of Cardiac Rehabilitation on Ferroptosis in Patients With Coronary Artery Disease
Coronary artery disease (CAD) remains a major global health concern and is the leading cause of cardiovascular mortality worldwide.
- Conditions
- Coronary Artery Disease (CAD), Cardiac Rehab, Ferroptosis
- Trial name
- NCT07722637
- Testing
- Cardiac Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
End-Stage Renal Disease
A Pharmacokinetics, Pharmacodynamics and Safety Study of Single Dose of Rivaroxaban in Participants With End-Stage Renal Disease (ESRD) on Maintenance Hemodialysis
The purpose of this study is to assess the pharmacokinetics (the study of the way a drug enters and leaves the blood and tissues over time) and pharmacodynamics (the way a drug may change body function) of a single 15-milligram…
- Trial name
- NCT02289703
- Testing
- Rivaroxaban 15 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Hypertension, Heart Failure
Finding Early Predictors of Myocardial Dysfunction
The study objective is to clarify the grounds of heart exertional dyspnoea stenocardia in patients with well-controlled stage I or II hypertension according to European Society of Hypertension, without changes in epicardial…
- Trial name
- NCT02026154
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Critical Limb Ischemia
A Safety and Tolerability Study of RJX Drug Product in Healthy Participants
Designed as a single center, two-part, double-blind, placebo-controlled, randomized study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of RJX in healthy participants.
- Trial name
- NCT03680105
- Testing
- RJX
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Reven Pharmaceuticals, Inc.
Diabetes
Investigating Ultrasound Debridement in Wound Care
The initial step of wound management, debridement, is thought to be critical in promoting wound healing. Of the numerous debridement modalities, ultrasound seems to hold promising results in accelerate healing in our own clinical…
- Trial name
- NCT03516422
- Testing
- ULTRASOUND DEBRIDEMENT, STANDARD CARE GROUP
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ischemic Stroke, Transient Ischemic Attack (TIA)
NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event
A natural form of vitamin E called tocotrienol (TCT), found in many common foods such as barley, decreases stroke size in animal models.
- Trial name
- NUTRITION (NCT01578629)
- Testing
- Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Andrew Slivka
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Cardiovascular Risk Factor, Heart Diseases
Effect of Macadamia Nut on Cardiometabolic Risk Factors
This research study will test the effects of macadamia nuts on adiposity, and traditional and emergent risk factors of cardiometabolic disease in adult men and women
- Conditions
- Cardiovascular Risk Factor, Heart Diseases, Inflammation
- Trial name
- MAC (NCT03801837)
- Testing
- Macadamia Nut, Control Diet
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.