Clinical trials: Cardiovascular
HIV Infections, HIV Seronegativity
Carotid Artery Thickness in HIV Infected and Uninfected Adults
The intima-media thickness (IMT) test is a low cost, non-invasive way to measure the thickness of the carotid artery (the large artery in the neck).
- Conditions
- HIV Infections, HIV Seronegativity, Atherosclerosis
- Trial name
- NCT00007319
- Where
- 10 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atherosclerosis
Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
Darapladib (SB-480848) is a novel, selective, orally active inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2) currently under clinical development by GlaxoSmithKline as a potential anti-atherosclerosis agent for…
- Trial name
- NCT01852565
- Testing
- Darapladib, Diltiazem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Community-dwelling Elderly
tDCS and the Cardiovascular System in Community-dwelling Elderly.
This study could contribute to the advancements in healthcare by exploring the innovative intervention, which is Transcranial Direct Current Stimulation (tDCS).
- Trial name
- NCT07573800
- Testing
- tDCS
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Marfan Syndrome, Ectopia Lentis
Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
Marfan syndrome is characterized by musculoskeletal manifestations, cardiovascular disease and ocular abnormalities, particularly ectopia lentis.
- Trial name
- NCT04319107
- Testing
- ophthalmological examinations using a slit lamp bio microscopy and a three-mirror lens, standard procedure.
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Radiation Effects
Brain Radiation Exposure and Attenuation During Invasive Cardiology Procedures
Invasive cardiac procedures involve procedural guidance with x-rays in the form of fluoroscopy. X-ray exposure poses a potential risk of acute and long-term complications to staff involved in these procedures.
- Trial name
- BRAIN (NCT01910272)
- Testing
- All subjects are wearing the non-lead attenuation cap (BLOXR)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
HIV Infections, Coronary Artery Disease
Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons
The primary purpose of this study is to evaluate the association between nonalcoholic fatty liver disease (NAFLD) by computed tomography (CT) scan and coronary artery disease (CAD) measured by the calcium (CAC) score among…
- Conditions
- HIV Infections, Coronary Artery Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT00889577
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Arrhythmias, Cardiac, Atrial Fibrillation
Screening of Cardiac Arrhythmias With Wrist-worn Aino ECG Cardiac Monitor
The study investigates the performance pf PulseOn Arrhythmia Monitor System that includes a wrist-worn device, which combines continuous optical heartbeat interval monitoring and intermittent ECG measurement, and a data…
- Trial name
- NCT05196412
- Testing
- PulseOn Arrhythmia Monitor device
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- PulseOn Oy
Stroke, Incentives
Stroke Patients' Outpatient Rehabilitation Therapy (SPORT)
Background: Stroke is the leading cause of long-term disability in Singapore, and studies have found that intensive specialized stroke rehabilitation can improve post-stroke functional outcomes for a substantial proportion of…
- Conditions
- Stroke, Incentives, Stroke Rehabilitation
- Trial name
- SPORT (NCT03165630)
- Testing
- Transportation incentives, Transportation and rehabilitation services incentives
- Where
- Singapore
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Visceral Fat, Fatty Liver
Visceral Abdominal Fat, Non Alcoholic Fatty Liver Diseases and Asymptomatic Coronary Atherosclerosis
Visceral fat or peri-omental fat is increasingly associated with metabolic syndrome, a condition carrying a high risk of coronary artery disease. The independent role of Visceral Fat in cardiovascular risk remains unclear.
- Conditions
- Visceral Fat, Fatty Liver, Atherosclerosis, Coronary Computed Tomography Angiography
- Trial name
- NCT01282892
- Testing
- excess of visceral fat, patients with NAFLD
- Where
- 2 sites in Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Obesity, Hypertension
The Effect of Phentermine and B12 on Weight Loss Among Obese Patients
This is a pilot study designed to test the hypothesis that the combination of phentermine and B12 will result in significantly greater weight loss among obese patients compared to phentermine alone.
- Trial name
- NCT01719185
- Testing
- Phentermine and B12, Phentermine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Lang
Elevated Blood Pressure
Baduanjin Lower Elevated Blood PreSsure Study
The aim of this study is to evaluate the effects of Baduanjin on blood pressure in individuals with high normal blood pressure (SBP 130-139 mmHg, and/or DBP 85-89 mmHg), as well as on glucose and lipid metabolism, quality of…
- Trial name
- BLESS (NCT05397535)
- Testing
- Baduanjin, Brisk walking
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hot Weather; Adverse Effect, Healthy
Characterization of Myocardial Blood Flow During Heat Exposure
The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.
- Conditions
- Hot Weather; Adverse Effect, Healthy, Coronary Artery Disease, Aging
- Trial name
- PET-Heat (NCT04549974)
- Testing
- Heat exposure
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Trisomy 13, Trisomy 18
High Risk Multiple Gestation Study
The objectives of the clinical study are to demonstrate the accuracy of our proprietary algorithm method to determine the genetic health of the developing fetuses in a multiple gestation pregnancy from a maternal blood sample.
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
- Trial name
- NCT02278874
- Where
- 4 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Cardiac Arrest
Improving Defibrillation Pad Position
Manufacturer's diagrams showing defibrillation pad positioning (as used on public access defibrillators) are anatomically incorrect and are likely to lead to poor position of defibrillation pads, with reduced defibrillation…
- Trial name
- NCT03476720
- Testing
- Pad positioning according to a manufacturer's diagram
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hypertension, High Blood Pressure
Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region Project 1 - Epidemiology (ACHIEVE P1-EPI)
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health…
- Trial name
- NCT06593496
- Testing
- Text Message Reminder
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Deep Vein Thrombosis
Targeted Metabolic Profiling in Deep Vein Thrombosis
Deep venous thrombosis(DVT) is a blood clot, usually affecting the legs, causing pain, swelling, and redness. The clot damages the veins, which can result in chronic pain, swelling and ulceration.
- Trial name
- NCT04096755
- Testing
- Procedure
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
NAFLD, Cardiovascular Diseases
Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: the Correlation Analysis and Risk Prediction Model Study
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. NAFLD is associated with a lot of comorbidity, such as diabetes, metabolic syndrome, coronary heart disease and chronic…
- Trial name
- NCT03534908
- Where
- China
- Volunteers
- 5,000,000 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Deep Vein Thrombosis, Superficial Thrombophlebitis
DOACT Algorithm Versus AI-Based Decision Models in Oral Anticoagulant Therapy for Vascular Patients
Study using a decision algorithm for the application of an oral anticoagulant calculator in vascular diseases, aimed at validating a clinical decision-support tool for conditions such as deep vein thrombosis, superficial…
- Conditions
- Deep Vein Thrombosis, Superficial Thrombophlebitis, Pulmonary Thromboembolisms, Clinical Decision Support Systems
- Trial name
- DOACT (NCT07290608)
- Testing
- DOACT algorithm, No algorithm, LLM-based tools
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- ITALO EUGENIO SOUZA GADELHA DE ABREU
Stroke
Perceptual-motor Interaction to Improve Bimanual Coordination After Stroke
Significant difficulty in incorporating the weaker arm in daily activities after stroke is, in part, driven by difficulty in engaging both arms interactively in a coordinated manner.
- Trial name
- Bimanual (NCT03755076)
- Testing
- Perceptual cuing
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
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