Clinical trials: Cardiovascular Adaption
Cardiovascular Diseases
Impact of Statin Therapy on Adaptations to Aerobic Exercise
The purpose of this study is to determine how different doses of a statin affect muscle health and exercise.
- Trial name
- NCT03360916
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet, Exercise Program
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Sedentary Behaviors, Physical Inactivity
Step-Up vs. Running Exercise at Matched Heart Rate Zones in Sedentary Males
This study compares the effects of two aerobic exercise methods - loaded step-up exercise and treadmill running - on cardiovascular fitness, leg strength, heart rate variability, and recovery in sedentary adult males.
- Trial name
- NCT07585617
- Testing
- Loaded Step-Up Exercise, Treadmill Running
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ankara University
Medication Non-adherence
Improving Adherence and Outcomes by Artificial Intelligence-Adapted Text Messages
Uncontrolled hypertension is a major cause of morbidity and mortality and many patients fail to take their antihypertensive medication as prescribed.
- Trial name
- AIM@BP (NCT02454660)
- Testing
- SMS (Text messages)
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Postmenopausal, Hypertension
Cardiometabolic Adaptations to Concurrent Training: Effect of Effort Configuration on Postmenopausal Women
The main objectives of this project are to assess the effects of a 20-week concurrent training program on neuromuscular adaptations, body composition, cardiometabolic health, quality of life, mood state, physical self-perception…
- Trial name
- CARE+E (NCT07377383)
- Testing
- Concurrent Training Program
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Disparities, Community Health Workers
Philly CEAL- DECIDE+ Adaptation
Cardiovascular disease (CVD) disproportionately affects racial/ethnic minorities and underserved populations in Philadelphia. This study aims to evaluate the effectiveness of an enhanced community health worker (CHW) program that…
- Conditions
- Disparities, Community Health Workers, Cardiovascular Diseases, Social Determinants of Health (SDOH)
- Trial name
- NCT06732102
- Testing
- DECIDE, Community Health Worker Support
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hypertension, Patient Engagement
Roy Adaptation Model in Hypertensive Patients
The aim of this study was to determine the effect of training given according to the Roy Adaptation Model on medical treatment and physiological, psychological and social adaptation to the disease in individuals with hypertension.
- Conditions
- Hypertension, Patient Engagement, Nurse-Patient Relations
- Trial name
- NCT05221424
- Testing
- Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Pre-Eclampsia, Vascular Diseases
Mechanisms of Pregnancy Vascular Adaptations
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples…
- Trial name
- NCT03806283
- Testing
- Omental Biopsy
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiovascular Disease
Effect of ACE Genotype on Cardiovascular Rehabilitation
The study aims to systematically investigate the interaction between training modality, ACE genotype and disease in heart patients whom complete a cardiovascular rehabilitation program.
- Trial name
- ACE-REHAB (NCT02845063)
- Testing
- concentric cardiovascular training, eccentric cardiovascular training, ACE genotyping
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stroke, Spinocerebellar Ataxia
Laryngeal Adaptation for Speech and Swallowing
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
- Conditions
- Stroke, Spinocerebellar Ataxia, Cerebral Stroke, Dysphagia
- Trial name
- NCT03770377
- Testing
- Intermittent Perturbation to Continuous Perturbation, Continuous Perturbation to Intermittent Perturbation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
IVF, Frozen Embryo Transfer (FET)
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
- Conditions
- IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI)
- Trial name
- NCT06471140
- Testing
- magnetic resonance imaging (MRI)
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Healthy Participants
The UBC Long-distance Triathlon Adaptation Study
The purpose of this study is to investigate the effect of 12-months of individualized endurance-training (swimming, cycling and running) on physiological and psychological adaptations in exercise naïve individuals.
- Trial name
- ULTRA (NCT06467656)
- Testing
- Individualized, periodized endurance training for ultra-endurance triathlon., Time-Aligned Control
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aphasia, Stroke
Adapted Solution Focused Therapy for People With Aphasia (SOFIA Trial)
Around one third of stroke survivors will have aphasia, which means they will have difficulty talking, understanding, reading or writing.
- Trial name
- SOFIA (NCT03245060)
- Testing
- Adapted Solution Focused Brief Therapy
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- City, University of London
Right Ventricular Hypertrophy, d-TGA
Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings
Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).
- Trial name
- NCT01430897
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Normal Physiology, Stroke
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation
Background: After a stroke, the balance between the two halves of the brain can be lost. This may cause people to lose the ability to perceive a side of space. This is called neglect.
- Trial name
- NCT02911129
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Augmentation of Locomotor Adaptation Post-Stroke
This project will evaluate two different methods of normalizing the center of mass acceleration (COMa) in individuals post-stroke, specifically focusing on rates and pattern of recovery to analyze walking-specific adaptations as…
- Trial name
- NCT02892084
- Testing
- tDCS
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy
Dose Adaptation to Offset the Interaction Between Ticagrelor and Ritonavir by Population-based PK Modeling
Ticagrelor is a new generation antiplatelet agent with higher efficacy as compared to clopidogrel and prasugrel in treatment of patients with moderate and high ischemic risks.
- Trial name
- NCT02435563
- Testing
- ticagrelor 180 mg administrated alone, Ticagrelor adjusted dose + ritonavir 100mg
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva