Clinical trials: Cardiovascular Autonomic Dysfunction
Cerebrovascular Accident, Baroreflexes
Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke
After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general.
- Conditions
- Cerebrovascular Accident, Baroreflexes, Autonomic Nervous System Diseases
- Trial name
- NCT00422474
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Arhythmia, Atrioventricular Heart-block
Observation of ImageReady™ MR Conditional Pacing System in China
To observe the safety and efficacy of ImageReady™ MR Conditional Pacing System in Chinese subjects
- Conditions
- Arhythmia, Atrioventricular Heart-block, Chronic Bundle Branch or Branch Block, Carotid Sinus Hypersensitivity Reaction Syndrome
- Trial name
- NCT02636712
- Testing
- ImageReady™ MR Conditional Pacing System
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Ischemic Stroke, Haemorrhagic Stroke
The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke
After stroke, blood vessels in the brain can become damaged, and the brain's ability to control blood flow can be impaired. The brain therefore may be less able to maintain a healthy level of blood flow during challenges such as…
- Conditions
- Ischemic Stroke, Haemorrhagic Stroke, Cerebrovascular Accident, Acute Stroke
- Trial name
- NCT04972812
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Sheffield Hallam University
Postural Orthostatic Tachycardia Syndrome
A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS
POTS is a relatively common condition that affects millions of patients around the globe. It has an estimated prevalence of 170/100,000 with approximately 80% of patients being women of childbearing age.
- Trial name
- NCT03365414
- Testing
- Albumin (Human) 5%, USP, Normal Saline 0.9% Infusion Solution Bag
- Sponsor
- University of Alberta
Orthostatic Hypotension
Spinal Cord Stimulation for Orthostatic Hypotension
This is a prospective single-center randomized crossover control study that aims to evaluate the effects of non-invasive transcutaneous spinal cord stimulation in patients with known or suspected orthostatic hypotension.
- Trial name
- NCT05230147
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Orthostatic Hypotension
Breathing Device for Orthostatic Hypotension (OH)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease blood pressure drops on standing in patients with orthostatic hypotension.
- Trial name
- NCT00962884
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Sponsor
- Alfredo Gamboa
Parkinson's Disease, Parkinsonism
Modifiable Variables in Parkinsonism (MVP)
We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD…
- Conditions
- Parkinson's Disease, Parkinsonism, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT02194816
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Bastyr University
Orthostatic Hypotension, Pure Autonomic Failure
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression…
- Conditions
- Orthostatic Hypotension, Pure Autonomic Failure, Multiple System Atrophy, Autonomic Failure
- Trial name
- NCT02429557
- Testing
- Abdominal compression, midodrine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS)
Two Point Discrimination
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of…
- Conditions
- Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), Amplified Musculoskeletal Pain Syndrome (AMPS), Low Back Pain
- Trial name
- TPD (NCT03686748)
- Testing
- Two-point discrimination training, One-point discrimination training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autonomic Failure, Orthostatic Hypotension
Treatment of Orthostatic Hypotension in Autonomic Failure
The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function.
- Trial name
- NCT00223691
- Testing
- Atomoxetine, Acarbose, Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- Vanderbilt University
Circulatory Collapse, Circulatory Failure
Suspension Syndrome
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness.
- Conditions
- Circulatory Collapse, Circulatory Failure, Syncope, Vasovagal, Neurally-Mediated, Orthostatic Hypotension
- Trial name
- NCT02726776
- Testing
- Suspension in a harness, Climbing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Coronary Artery Spasm, Hypertension
The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering…
- Trial name
- NCT01882790
- Where
- 3 sites in South Korea
- Volunteers
- 1,933 people
- Sponsor
- Korea University
Heart Failure
Cardiac Autonomic Dysfunction As a Sign of Irreversible Advanced Heart Failure
The main hypothesis is that autonomic dysfunction cannot improve among patients reaching end-stage heart failure. To evaluate this, patients admitted with acute decompensated heart failure in Bispebjerg hospital, and history one…
- Trial name
- CADYSH (NCT06532825)
- Testing
- heart monitoring
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Stroke, Cardiac Disease
Multifactorial Risk Stratification in Stroke Patients With Cardiac Disease
Prospective registry for multifactorial risk factor assessment, enrolling consecutive ischemic stroke/transient ischemic attack patients with structural, inflammatory, or arrhythmogenic cardiac disease, who are admitted to our…
- Trial name
- NCT04352790
- Volunteers
- 878 people
- Sponsor
- University Hospital Tuebingen
Myocardial Infarction, Autonomic Nervous System Diseases
Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction
The majority of deaths after myocardial infarction occurs in patients with preserved left ventricular ejection fraction (>35%) for whom no prophylactic strategies exist.
- Trial name
- SMART-MI (NCT02594488)
- Testing
- Medtronic Reveal LINQ implantable cardiac monitor
- Where
- 32 sites in Austria, Germany
- Volunteers
- 400 people
- Sponsor
- LMU Klinikum
Orthostatic Intolerance, Orthostatic Hypotension
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)
Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic hypotension in patients undergoing unilateral THA
- Conditions
- Orthostatic Intolerance, Orthostatic Hypotension, Postoperative Complications
- Trial name
- NCT03759574
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Hvidovre University Hospital
PSP, PSP - Progressive Supranuclear Palsy
The CurePSP Genetics Program
This study is an observational, prospective genetic study. It aims to obtain DNA for research and testing from patients with PSP, CBS, MSA, and related neurological conditions and their families.
- Conditions
- PSP, PSP - Progressive Supranuclear Palsy, Corticobasal Syndrome, Corticobasal Syndrome(CBS)
- Trial name
- NCT06647641
- Testing
- Whole genome sequencing will be performed at the NIH
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries, Cardiovascular Condition
Effect of Three Training Programs on the Cardiovascular Condition of Individuals with Spinal Cord Injury
Objective: Describe the effect of different aerobic training programs on the autonomic nervous system (ANS), cardiovascular condition, body composition, metabolic profile, movement and functional independence in patients with…
- Conditions
- Spinal Cord Injuries, Cardiovascular Condition, Exercise
- Trial name
- NCT06627881
- Testing
- Continuous aerobic kayak training program, Aerobic Endurance Circuit Program, High intensity interval program with rope
- Where
- Mexico
- Volunteers
- 63 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Orthostatic Hypotension
SalT Supplementation in Older Adults With Orthostatic Intolerance Disorders
Background Orthostatic hypotension (OH) is a common cause of falls, and key source of morbidity and mortality due to injury (e.g. hip fracture).
- Trial name
- STOOD (NCT06188663)
- Testing
- Salt supplementation (encapsulated sodium chloride)
- Where
- Ireland
- Volunteers
- 42 people
- Sponsor
- University of Galway