Clinical trials: Cardiovascular Biomarkers
Congestive Heart Failure
Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)
This is a prospective, double blinded randomized clinical study to evaluate the Effects of Pentoxifylline on left ventricular systolic function indices and circulating biomarkers in patients with chronic congestive heart failure.
- Trial name
- PENT-CHF (NCT01337349)
- Testing
- Pentoxifylline
- Where
- United States
- Sponsor
- Henry Ford Health System
Myocardial Infarction
Effect of Renin Angiotensin Aldosterone System Genetic Polymorphism on the Pharmacological Effect of Mineralocorticoid Receptor Antagonists in Patients With Myocardial Infarction
Early treatment of Myocardial Infarction patients with mineralocorticoid receptor antagonist with help reduces the incidence of cardiac remodeling and development into heart failure.
- Trial name
- NCT05873400
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Cardiotoxicity, Aluminum Phosphid Poisoning
Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers
Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas.
- Trial name
- NCT04191265
- Testing
- serum tropinin, serum CKmb
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Stroke, Biomarker
Serum BDNF Role as a Biomarker for Stroke Rehabilitation
This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping…
- Conditions
- Stroke, Biomarker, Rehabilitation, BDNF
- Trial name
- BDNF (NCT03164798)
- Testing
- Conventional inpatient rehabilitation
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation
Investigation of Specific Biomarkers in Patients With Atrial Fibrillation Who Undergo Interventional Treatment
The two main mechanisms for atrial fibrillation (AF) recurrence after cryoablation include Pulmonary vein (PV) reconnection and the presence of non-PV associated arrhythmic focuses.
- Trial name
- NCT05170607
- Testing
- Proteomic analysis by antibody microarrays
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Angiocardiography, Heart Failure
Identification and Functional Study of Novel Biomarkers for Cardiovascular Diseases
Cardiovascular diseases, mainly represented by ischemic heart disease and heart failure, are the number one killers of human health today.
- Conditions
- Angiocardiography, Heart Failure, Ischemic Heart Disease, Acute Myocardial Infarction (AMI)
- Trial name
- NCT06690684
- Testing
- Hematological indicators, Serological indicators in patients with myocardial infarction, Levels of biomarkers in blood of patients with acute myocardial infarction
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ya-Wei Xu
Atrial Fibrillation (AF)
Predicting Disease Progression in Atrial Fibrillation: A Multiparametric Approach for Prognostic Marker Identification and Personalized Patient Management
This project leverages artificial intelligence (AI) to decipher Atrial Fibrillation (AF) progression and optimize treatment strategies.
- Trial name
- PAMP FA (NCT06647914)
- Volunteers
- 322 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Acute Ischemic Stroke
The Role of OXytocin in Acute Ischemic Stroke reconvAlesceNcE: The ROXANE Study
Evidence suggests that oxytocin has a neuroprotective role on a systemic and cellular level in the context of acute ischemic stroke (AIS).
- Trial name
- ROXANE (NCT05873309)
- Where
- Switzerland
- Volunteers
- 386 people
- Sponsor
- University Hospital, Basel, Switzerland
Hemorrhagic Stroke, Intracerebral, Cerebral Cavernous Malformation
CCM Blood Biomarker Validation Study
Cerebral cavernous malformations (CCMs), one of the most common microvascular malformations in the capillary beds of the brain, are susceptible to hemorrhagic stroke.
- Trial name
- NCT05148663
- Testing
- CCM Hemorrhagic Panel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Decompensated Heart Failure
Impact of Therapy Optimization on the Level of Biomarkers in Patients With Decompensated Heart Failure
In this pilot, investigator-initiated multi-centre, multinational, observational study the investigators would like to examine the impact of therapy optimization on the level of biomarkers in patients with acute decompensated and…
- Trial name
- MOLITOR (NCT01501981)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Chest Pain
Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients
Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized.
- Trial name
- dp/dt (NCT05416112)
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Retinal Vein Occlusion, Vascular Occlusive Disease
Intravitreal Aflibercept for Macular Edema Due to Central Retinal Vein Occlusion
Central retinal vein occlusion (CRVO) is a common retinal vascular disorder, occurring when there is a blockage to the main blood vessel that transports blood away from the retina.
- Trial name
- INTRAMED-CRVO (NCT06416241)
- Testing
- EYLEA 2 MG in 0.05 ML Injection
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Athens
Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF
Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. As an independent predictor of cardiovascular mortality, particularly for stroke, its management is a real public health issue.
- Conditions
- Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF, Able to Give His Non Opposition to Participate to the Study
- Trial name
- PROFIB-AF (NCT05179902)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cerebral Infarction
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke
Single-center, prospective, descriptive and biomedical research with controls, without health product. Depression is the second risk factor for stroke as tobacco smoking following hypertension.
- Trial name
- NCT02963545
- Testing
- Usual care patients in neurology department, blood and urines sampling, Psychiatric evaluation
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Versailles Hospital
Susac Syndrome
Investigation of Biomarkers in Susac Syndrome
Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome
- Trial name
- NCT01273792
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Disease
Liquid Biopsy System Intracoronary Blood Sampling and Analysis to Characterise Disease Biomarkers in Patients With Coronary Disease
The aim of this research, proposed and funded by PlaqueTec and co-ordinated by Papworth Trials Unit Collaboration, is to demonstrate the performance of the coronary artery blood sampling device (Liquid Biospy System, LBS) and…
- Trial name
- BIOPATTERN (NCT06259019)
- Testing
- Liquid Biopsy System (LBS)
- Where
- 4 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- PlaqueTec Ltd
Alzheimer Disease, Cognitive Impairment
The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers
The goal of this observational study is to determine whether the early adoption of blood-based biomarkers for Alzheimer's disease is associated with an impact on etiological diagnosis, patient's management, emotional impact…
- Conditions
- Alzheimer Disease, Cognitive Impairment, Dementia, Neurodegenerative Diseases
- Trial name
- PLASMAR (NCT06246019)
- Testing
- Early adoption of blood-based biomarkers for Alzheimer's disease
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Atrial Fibrillation, Inflammatory Marker
Red Cell Distribution Width as a Predictor for Post Operative Atrial Fibrillation After Open Heart Surgries
In this study we investigate the correlation between RDW and POAF, as we use the RDW as a predictor for inflammation for prediction of POAF
- Conditions
- Atrial Fibrillation, Inflammatory Marker, Heart; Surgery, Heart, Functional Disturbance as Result
- Trial name
- NCT06286111
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Stroke, Ischemic
Network Properties As Biomarkers for Non-Invasive Brain Stimulation (NIBS) After Stroke
The present study will evaluate the potential of cortico-cerebellar network properties derived from neuroimaging in a group of chronic stroke patients to explain inter-subject variability in responsiveness to transcranial direct…
- Trial name
- MARK-NIBS (NCT05560724)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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