Clinical trials: Cardiovascular Biomarkers
Asthma, COPD
Exhaled Breath Metabolomic Biomarkers in the Acutely Breathless Patient
An acute study carried out across three acute admissions units within Leicestershire. The study is aimed at discovery and validation of volatile organic compounds (VOCs) in exhaled breath.
- Conditions
- Asthma, COPD, Heart Failure, Community-acquired Pneumonia
- Trial name
- EMBER (NCT03672994)
- Where
- United Kingdom
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Cardiovascular Disease
Effect of Wine Consumption on Cardiovascular Markers in CHDs Patients
Many epidemiological studies support that 20-30gr of alcohol consumption per day is related with lower risk for cardiovascular diseases, heart attack as well as mortality related to these diseases.
- Trial name
- NCT04438122
- Testing
- Cabernet Sauvignon, Tsipouro
- Where
- Greece
- Volunteers
- 57 people
- Sponsor
- Harokopio University
Elevated Blood Pressure
Trial of Oral Melatonin in Elevated Blood Pressure
Since, lowering blood pressure (BP) in elevated blood pressure individuals represents an excellent opportunity to for primary prevention of hypertension (HTN).
- Trial name
- MRCTEBP (NCT03764020)
- Testing
- Melatonin/experimental
- Volunteers
- 320 people
- Sponsor
- Tehran University of Medical Sciences
Interstitial Lung Disease, Cardiovascular Morbidity
Interstitial Lung Disease is a Risk Factor for Cardiovascular Disease
A group of Interstitial pulmonary fibrosis will be recruited from Assiut university hospital outpatient clinic. Evaluation will be done regarding cardiovascular comorbidities (Cardiovascular comorbidities will be evaluated with…
- Trial name
- NCT06539962
- Testing
- Krebs von den Lungen-6 (KL-6)
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Assiut University
Statin Treatment for Primary Prevention
STREAM Trial - Biomarker
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM-Bio (NCT05482386)
- Testing
- Statin discontinuation
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prehypertension, Hypertension
Health Effects of a Nordic Diet Rich in Plant-based Foods and Fish
The purpose of this study is to investigate the effects of a Nordic diet rich in plant-based foods and fish on indicators of cardiovascular disease risk at two different levels of salt intake.
- Trial name
- NCT01412346
- Testing
- Effects of a Nordic diet rich in plant-based foods and fish
- Where
- Finland
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Oxidative Stress, Atherosclerosis
Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals
Low-density lipoprotein (LDL) oxidation has a pivotal role in atherosclerosis development. There is a relationship between carotenoids serum concentration and cardiovascular (CV) benefits, mainly in oxidized LDL (oxLDL)…
- Trial name
- NCT03820245
- Testing
- Bixin, Norbixin, Lycopene
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Aneurysmal Subarachnoid Hemorrhage
The Role of Biomarker in Serum, Cerebrospinal Fluid and Parenchyma in the Context of Aneurysmal Subarachnoid Hemorrhage.
The aim of this study is to improve the usability of biomarkers for the timely prediction of new complications following a cerebral hemorrhage, especially in combination with invasive, functional and local measurements for…
- Trial name
- bioSAB (NCT02142166)
- Testing
- Biomarker in serum, liquor, micro-dialysate, Biomarker in serum and in liquor
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- RWTH Aachen University
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Acute Intradialytic Hypotension
Observational Study to Assess Oxygen Saturation Predictive Power Related to Intradialytic Acute Hypotension
The aim of the present work was to analyze the short-term variability of SO2 during hemodialysis in sessions with and without hypotension to correlate the SO2 variability to hemodynamic instability.
- Trial name
- SOGLIA (NCT01759641)
- Testing
- Hypotension-prone patients
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
OCT Angiography, Atrial Fibrillation (AF)
OCT-A Biomarkers for Cognitive Impairment in Patients With Chronic Atrial Fibrillation
The OCTAF study is a monocentric, cross-sectional pilot study designed to investigate the relationship between retinal microvascular biomarkers and cognitive impairment in patients with atrial fibrillation (AF).
- Conditions
- OCT Angiography, Atrial Fibrillation (AF), Mild Cognitive Impairment
- Trial name
- OCTAF (NCT07607756)
- Testing
- OCT-angiography
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Out-of-Hospital Cardiac Arrest, Ventricular Fibrillation
DIagnostics, Fatty Acids and Vitamin D in SCA
Sudden cardiac death (SCD) is a major cause of mortality in industrialized countries and represents a major health issue. The survival rate after out-of-hospital cardiac arrest (OHCA) is only 10-15%, regardless of first recorded…
- Trial name
- DIFAD-SCA (NCT02886273)
- Testing
- Group 1, Group 2, Group 3
- Where
- Norway
- Volunteers
- 116 people
- Sponsor
- Helse Stavanger HF
Multiple Myeloma
Lenalidomide Maintenance Therapy for Multiple Myeloma
Background: Multiple myeloma is rarely curable, but it is treatable. Initial treatment is directed at controlling symptoms and reducing the number of myeloma cells. It continues until the cancer stops responding to treatment.
- Trial name
- NCT01675141
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Single-ventricle
Validation of Cardiac Magnetic Resonance Sequences in Patients With Single Ventricles
Single ventricle defects make up the severe end of the congenital heart disease spectrum. The Fontan operation leads to a complete redirection of systemic venous blood outside of the heart and directly into the lungs.
- Trial name
- NCT04017494
- Testing
- Cardiac Magnetic Resonance Imaging, Blood draw for hematocrit and heart failure biomarkers, Cardiopulmonary exercise test
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Barbara Burkhardt
Aortic Dissection
Significance of Serum Tenascin C in Patients With Acute Aortic Disease
This study aims to investigate Serum Tenascin C levels in patients with acute symptoms relating to a known or newly diagnosed aortic aneurysm in emergency department and reveals the possible role of Tenascin C in the development…
- Trial name
- NCT02816892
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Central South University
Post COVID-19, Endothelial Dysfunction
Endothelial Protection in Post COVID-19 Patients With Sulodexide
This is a Prospective, multicenter, randomized (1:1, placebo use) trial with a parallel-group design to assess if the use of sulodexide influences serum levels of biomarkers for endothelial dysfunction on convalescent COVID-19…
- Conditions
- Post COVID-19, Endothelial Dysfunction, Thrombosis
- Trial name
- NCT05371925
- Testing
- Sulodexide
- Where
- Mexico
- Volunteers
- 206 people
- Sponsor
- Centro Medico del Noroeste
Vascular Disease, Peripheral, Thromboprophylaxis
Heparin-Binding Protein and Heparins
Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis.
- Conditions
- Vascular Disease, Peripheral, Thromboprophylaxis, Cardiovascular Diseases
- Trial name
- HepHep (NCT04146493)
- Testing
- Blood samples for Heparin-binding protein measurement
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Halla Halldorsdottir
Congenital Heart Disease
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
Background: In Fontan Associated Liver Disease (FALD), congestion of blood in the liver causes cirrhosis. This condition can cause death. Researchers want to understand what triggers this process and find new treatments for it.
- Trial name
- NCT05213598
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 2
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
A. Four groups of patients with type 2 diabetes mellitus with high or very high cardiovascular risk or heart failure with preserved ejection fraction (HFpEF) will be studied before and at 6 and 12 months of treatment: 60 patients…
- Trial name
- NCT03878706
- Where
- Greece
- Volunteers
- 240 people
- Sponsor
- University of Athens
Myocardial Infarction, Acute
Biomarkers in Patients Hospitalized With Suspected Acute Myocardial Infarction
The concentration of troponins in plasma is used for diagnosing acute myocardial infarction. Different types of heart-specific troponins can be measured and with different analytical methods.
- Trial name
- BIOMAC (NCT04167904)
- Where
- Norway
- Volunteers
- 4,446 people
- Sponsor
- St. Olavs Hospital
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