Clinical trials: Cardiovascular Biomarkers
Heart Failure，Congestive
Serum Catestatin Expression and Cardiometabolic Parameters in Patients With Congestive Heart Failure
The congestive heart failure (HF) is a condition associated with substantial morbidity, mortality, and high healthcare expenditures.
- Trial name
- CATSTAT-HF (NCT03389386)
- Testing
- Blood withdrawal for laboratory analysis, Standard-of-care treatment, Transthoracic echocardiography (TTE)
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Josko Bozic
Serum, Lipoprotein(A)
Serum Lipoprotein-a as a Marker of Severity of Coronary Artery Disease in Aortic Valve Sclerosis Patients
This work aimed to evaluate the association of serum level of Lp(a) with the severity of coronary artery disease (CAD) in aortic valve sclerosis (AVS) patients.
- Conditions
- Serum, Lipoprotein(A), Severity, Coronary Artery Disease
- Trial name
- NCT07209631
- Testing
- Serum Lipoprotein-a level
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Multiple Myeloma
Value of Macrophage-Colony Stimulating Factor as a New Marker of Bone Lesions in Multiple Myeloma
The Primary objective of this study is to compare serum levels of Macrophage-Colony Stimulating Factor (M-CSF) in a population of patients with multiple myeloma (MM), in a population of patients with Monoclonal Gammopathy of…
- Trial name
- MCSF-MYELOME (NCT02800954)
- Testing
- blood samples, Bone marow samples
- Where
- 3 sites in France
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cancer, Venous Thromboembolism
Identification of Novel Biomarkers to Aid in the Detection of Occult Cancer in Patients With Venous Thromboembolism
Venous thromboembolism is a common and serious complication in cancer, and is associated with a substantially increased morbidity and mortality. Furthermore, VTE may be the earliest sign of cancer.
- Trial name
- NCT03781531
- Where
- 2 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Danderyd Hospital
Atherosclerosis
Integrated Biomarker And Imaging Study - 2
IBIS-2 is a study using SB-480848 versus placebo in subjects with angiographically documented coronary heart disease. Endpoints include coronary imaging, endothelial function, biomarkers, safety and tolerability.
- Trial name
- NCT00268996
- Testing
- SB-480848
- Where
- 26 sites in Austria, Belgium and 9 more
- Volunteers
- 336 people
- Sponsor
- GlaxoSmithKline
Pulmonary Embolism
Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath
In this study, a new, non-invasive method for diagnosis of pulmonary embolism (PE) will be tested. In pre-clinical studies, the investigators have identified 151 putative biomarkers for pulmonary embolism in the exhaled breath…
- Trial name
- NILEX (NCT06135220)
- Testing
- New method for diagnosis of pulmonary embolism (PE) in order to validate/consolidate 151 putative identified biomarkers for PE in the exhaled breath.
- Where
- Denmark
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Stroke, Ischemic
Network Properties As Biomarkers for Non-Invasive Brain Stimulation (NIBS) After Stroke
The present study will evaluate the potential of cortico-cerebellar network properties derived from neuroimaging in a group of chronic stroke patients to explain inter-subject variability in responsiveness to transcranial direct…
- Trial name
- MARK-NIBS (NCT05560724)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Cardiovascular Diseases
Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH)
The purpose of this randomized, cross-over study, is to ascertain if ticagrelor, but not prasugrel or clopidogrel, is associated to an improved endothelial function as assessed with peripheral arterial tonometry and markers of…
- Trial name
- HI-TECH (NCT02587260)
- Testing
- Ticagrelor, Prasugrel, Clopidogrel
- Where
- 5 sites in Italy, Netherlands and 2 more
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Venous Leg Ulcer
Assessment of the Evolution of Wound Biomarkers in Venous Leg Ulcers Treated With KLOX Biophotonic System
The main purpose of the study is to evaluate the effect of KLOX BioPhotonic System (composed of KLOX LumiHeal Gel and KT-L Lamp) on the expression of wound biomarkers in the treatment of venous leg ulcers (VLU).
- Trial name
- NCT03593369
- Testing
- KLOX BioPhotonic System (single treatment)+SOC, KLOX BioPhotonic System (consecutive treatments)+SOC, Standard of Care (SOC)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- KLOX Technologies Inc.
Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
Metabolomic Profile and Proteasic Activity as Biomarkers for Early Detection of Arterial Vasospas in Arterial Vasospasm After Aneurysmal Subarachnoid Hemorrhage
The subarachnoid hemorrhage (SAH) from ruptured aneurysm is a situation that is life-threatening, which is largely dependent on the occurrence of vasospasm from the 4th day after the bleeding.
- Trial name
- NCT02397759
- Testing
- Blood draw and cerebrospinal fluid draw
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pulmonary Embolism
Semaglutide Use in Acute Pulmonary Embolism
Evaluation of circulating endothelial inflammatory biomarkers in response to GLP-1 agonist Semaglutide in acute pulmonary embolism
- Trial name
- NCT06118203
- Testing
- Semaglutide
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Multiple Myeloma, Leukemia
Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study
Background: Multiple myeloma (MM), a type of cancer that affects the white blood cells, is often preceded by a precancerous disorder known as monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Multiple Myeloma, Leukemia, MGUS, Monoclonal B-Cell Lymphocytosis
- Trial name
- NCT01139476
- Where
- United States
- Volunteers
- 1,892 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases
A Registry Study of Biomarkers in Progression of Acute Heart Failure(BIOMS-POAHF)
The registry study aims to discover the prognostic value of bio-markers in acute heart failure
- Trial name
- NCT04108182
- Where
- China
- Volunteers
- 850 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Atrial Fibrillation (AF)
Identification of the Metabolic Signature of Atrial Fibrillation for Personalized Prevention
Atrial fibrillation (AF) is a major public health problem. The efficacy of the existing techniques is limited in the more aggressive forms.
- Trial name
- IMAGE-AF (NCT06735001)
- Testing
- FA ablation, Lab test
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Acute Heart Failure (AHF), Sarcopenia
Sarcopenia in Older Patients Hospitalized for Acute Heart Failure.
Acute heart failure (AHF) is the leading cause of hospitalization in people over 65, with the group with preserved ejection fraction (HFpEF) being the most closely related to aging.
- Conditions
- Acute Heart Failure (AHF), Sarcopenia, Heart Failure
- Trial name
- MUSICA (NCT07530029)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Stroke, Stroke Rehabilitation
Biomarkers of Reaction To HIIT Exercise
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy.
- Conditions
- Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty
- Trial name
- BReaTHE (NCT06059872)
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Dietary Modification, Cardiovascular Disease
Feeding the Rainbow to Investigate Endothelial Dysfunction
The primary purpose of this study is to compare the change in blood carotene concentration between a food-based versus nutritional supplement-based intervention.
- Trial name
- FRIED (NCT01175577)
- Testing
- Chlorophyll complex, Standard Process, Betatene, sold as "Full Spectrum Carotenoid Complex", Small carotenoid-rich meals
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Cardiac Arrest
Intravascular Clotting (POCUS) - Marker of the Timing and Severity of Cardiac Arrest; Indicator of Futile Resuscitation
The scientific goals of the project: 1. ultrasound assessment of the incidence of clotting in deep veins in patients after cardiac arrest during resuscitation and after the declaration of death; comparison to the incidence of…
- Trial name
- NCT06406920
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
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