Clinical trials: Cardiovascular Biomarkers
Peripheral Arterial Disease
Peripheral Arterial Disease Biomarkers
The study aims to determine how expression levels of biomarkers for peripheral arterial disease change over time in response to exercise therapy, surgical or endovascular intervention, and whether they can be used to predict…
- Trial name
- PADBIRD (NCT06373302)
- Volunteers
- 100 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Type 2 Diabetes, Coronary Artery Disease (CAD)
Effect of a Low Advanced Glycation End Products Diet of Patients With Type 2 Diabetes Mellitus
The present study showed that a reduction of approximately 56% in CML consumption promoted a 30% reduction in this blood biomarker.
- Trial name
- NCT07303842
- Testing
- a low-CML diet, Control
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- InCor Heart Institute
Emotional Well-being, Psychological Stress
Feasibility of a Mind-Body Intervention for Optimism
This pilot study tests whether three brief mind-body activities can be delivered remotely to midlife adults, and whether they show early signs of improving cardiovascular health, emotional well-being, and stress.
- Conditions
- Emotional Well-being, Psychological Stress, Cardiovascular Risk
- Trial name
- NCT07862478
- Testing
- Emotional Well-Being Writing, Chair-Assisted Squats, Slow-Paced Breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Penn State University
Stroke Acute
NanO2 in Large VessEL Occlusion Stroke (NOVEL)
This is a National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) clinical trial aiming to investigate a possible new treatment to limit damage to the brain caused by a stroke.
- Trial name
- NOVEL (NCT06821347)
- Testing
- NanO2TM, Sodium Chloride 0.9% Intravenous
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Greater Glasgow and Clyde
Heart Failure
Markers and Response to Cardiac Resynchronization Therapy
The purpose of this study is to investigate: the relation of a set of (bio)markers and response to Cardiac Resynchronization Therapy (CRT); the interrelationship as well as the potential predictive power of these (bio)markers on…
- Trial name
- MARC (NCT01519908)
- Testing
- CRT-D (Medtronic)
- Where
- 6 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Stroke
Blood Proteome Profiling Identifies Biomarkers in Ischemic Stroke
Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the…
- Trial name
- NCT06729385
- Testing
- The blood Proteome Profiling
- Where
- 4 sites in China
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Glomerulonephritis Acute
Urinary T Lymphocytes Predict Renal Flares in Patients With Inactive ANCA-associated Glomerulonephritis
Urinary CD4+ and CD8+ T lymphocytes may predict renal flares in patients with inactive ANCA-associated vasculitis and thus serve as early non-invasive biomarkers.
- Trial name
- PRE-FLARED (NCT04428398)
- Testing
- Analysis of urine samples with flow cytometry
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Atrial Fibrillation
Left Atrial Appendage Occlusion and Biomarker Evaluation
"Left Atrial Appendage Occlusion and Biomarker Evaluation" (LABEL) is a single-center, prospective and observational study evaluating changes of the expression of biomarkers in eligible patients before and after percutaneous…
- Conditions
- Stroke, Atrial Fibrillation, Bleeding
- Trial name
- LABEL (NCT02985463)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsmedizin Mannheim
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Cerebral Ischemia
Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury
The purpose of this study is to use an iatrogenic model of stroke, meaning those strokes inadvertently caused by endovascular coiling of elective aneurysms, to study the biology of stroke in humans.
- Trial name
- NCT02389647
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Supportive Care, Metabolic Syndrome
Green Coffee Effect on Metabolic Syndrome
The present study aimed to investigate the effect of green coffee bean extract (GCBE) on the inflammatory biomarkers in obese patients with a metabolic syndrome via analyzing some inflammatory biomarkers as resistin, TNF-α, total…
- Conditions
- Supportive Care, Metabolic Syndrome, Obesity, Hypertension
- Trial name
- NCT05688917
- Testing
- Green coffee been extract
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Tanta University
Hypercholesterolemia
Replacement of Saturated Fat in Dairy on Total Cholesterol
The consumption of milk and dairy products is recognised as an essential part of a healthy diet as it represents an important source of key micro- and macronutrients.
- Trial name
- RESET (NCT02089035)
- Testing
- MUFA-rich dairy products (UHT milk, cheese and butter), Conventional dairy products (UHT milk, cheese, butter)
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Reading
Perioperative/Postoperative Complications, Risk Factor, Cardiovascular
Myocardial Injury in Noncardiac Surgery in Sweden
The purpose of this multicentre, prospective, observational study is to identify robust biochemical markers that predict adverse cardiovascular outcomes and mortality in patients undergoing major abdominal surgery.
- Trial name
- MINSS (NCT03436238)
- Where
- 7 sites in Sweden
- Volunteers
- 1,269 people
- Sponsor
- Linkoeping University
Takotsubo Cardiomyopathy, Sepsis-induced Cardiomyopathy
Characterization of priMary And sEcondary STress Related takOtsubo
Takotsubo syndrome (TTS) is an acute and reversible form of myocardial injury often preceded by a physical or emotional trigger.
- Trial name
- MAESTRO (NCT05793008)
- Testing
- Positron Emission Tomography (PET) analysis, Blood samples collection, Clinical follow up visit
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Neoplasms, Cardiovascular Diseases
Acute and Long-term Cardiovascular Toxicity After Modern Radiotherapy for Breast Cancer
In Europe, breast cancer is by far the most common form of cancer diagnosed in women today, accounting for 29% of all cases. The 5-year survival rate is approximately 90%.
- Trial name
- NCT02541435
- Where
- 2 sites in Norway
- Volunteers
- 1,600 people
- Sponsor
- St. Olavs Hospital
Ischemic Stroke
The Level of Blood Brain Barrier Damage Biomarker in Acute Ischemic Stroke
Hemorrhagic transformation is a common complication of acute ischemic stroke patients . BBB damage is regarded as a major pathophysiological mechanism of hemorrhagic transformation.
- Trial name
- NCT05321225
- Testing
- the level of biomarker in bood
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Ji Xunming,MD,PhD
Ischemic Stroke, Myocardial Ischemia
Coronary Arteriosclerosis in Patients With Acute Ischemic Stroke
The specific objectives of this thesis are in a cohort of patients with an acute ischemic stroke, 1. To establish the degree of coronary arteriosclerosis. 2.
- Conditions
- Ischemic Stroke, Myocardial Ischemia, Coronary Arteriosclerosis
- Trial name
- CORAIS (NCT00701818)
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Vejle Hospital
Pulmonary Embolism, Interstitial Lung Disease
Predictors of Pulmonary Embolism in Interstitial Lung Disease With Worsening Symptoms
People with interstitial lung disease (ILD) can sometimes experience a sudden and severe worsening of their breathing. While this can be caused by a flare-up of the lung disease itself, it can also be caused by a blood clot in…
- Conditions
- Pulmonary Embolism, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Connective Tissue Disease-associated Interstitial Lung Disease
- Trial name
- NCT07728448
- Volunteers
- 70 people
- Sponsor
- Assiut University
Myocardial Infarction, Secondary Prevention
Improving Cardiac Secondary Prevention
The purpose of this study is to determine whether providing individuals with personalized information on cellular aging, including telomere length, will stimulate them to adhere to cardiac prevention strategies and improve…
- Trial name
- NCT03269708
- Testing
- Education regarding telomere length
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
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