Clinical trials: Cardiovascular Biomarkers
Atrial Fibrillation
Investigation of Specific Biomarkers in Patients With Atrial Fibrillation Who Undergo Interventional Treatment
The two main mechanisms for atrial fibrillation (AF) recurrence after cryoablation include Pulmonary vein (PV) reconnection and the presence of non-PV associated arrhythmic focuses.
- Trial name
- NCT05170607
- Testing
- Proteomic analysis by antibody microarrays
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Chest Pain, Acute Coronary Syndrome
High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain
The purpose of this study is to determine the efficacy and safety of an evaluation strategy based on utilization of high sensitivity cardiac troponin T (hscTnT), followed by coronary computed tomography angiography (CCTA) in…
- Trial name
- TRUE (NCT01836211)
- Testing
- Fast strategy, Standard of care strategy
- Where
- Spain
- Volunteers
- 101 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stroke, Motor Activity
Biomarkers to Predict Gain From Therapy in Motor Stroke
The aim is to determine predictors of treatment response, i.e gain from rehabilitation training, in post stroke upper limb deficits.
- Conditions
- Stroke, Motor Activity, Biomarker
- Trial name
- GAIN (NCT03739892)
- Testing
- standard stroke rehabilitation
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intracranial Hemorrhage, Spontaneous
Prediction of Functional Recovery in Patients With Intracerebral Hemorrhage
Currently, we lack sufficiently reliable tools to accurately predict, in the first few hours, the vital prognosis, functional status, and quality of life of patients with intracerebral hemorrhage (ICH).
- Trial name
- PRO-ICH (NCT07728734)
- Testing
- CLINICAL SCORE TO PREDICT FUNCTIONAL OUTCOME, Variables necessary for calculating the score under study (PRO-ICH) will be collected, as well as baseline and 60-120 minutes after baseline of serum blood samples
- Where
- Spain
- Volunteers
- 1,688 people
- Sponsor
- Germans Trias i Pujol Hospital
Alzheimer Disease, Mild Cognitive Impairment
Novel Diagnostic and Disease Stage Biomarkers in AD
This study will investigate the efficacy of novel biomarkers, namely blood-based biomarkers, pupillometry and actigraphy to track and predict progression of Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neuro-Degenerative Diseases, Vascular Dementia
- Trial name
- TRACK-AD (NCT05175664)
- Testing
- Long-term study, Short-term study, Cross-sectional study
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Danish Dementia Research Centre
Lipoprotein(a)
Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening
Lipoprotein(a), or Lp(a), is a type of cholesterol that can increase the risk of heart and blood vessel disease. Many people are unaware they have high Lp(a), since it is not routinely measured and usually causes no symptoms on…
- Trial name
- IMAGE-LPA (NCT06995183)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- E.S.stroes
Acute Ischemic Stroke, Reperfusion Injury
Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Background: Recanalization strategies have radically changed the outcome in a significant part of stroke patients. The unpredictable occurrence of cerebral edema (CE) and hemorrhagic transformation (HT) are frequent events in…
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- STROKELABED (NCT05725694)
- Volunteers
- 200 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Unstable Angina
Ischemia Driven Enoxaparin Therapy in ACS Presenting as Low Risk (IDEAL)
The purpose of this study is to determine whether enoxaparin (an anticoagulant) is effective in the treatment of patients presenting to the emergency room with chest pain and no electrocardiogram or bloodwork evidence of a heart…
- Trial name
- IDEAL (NCT00518245)
- Testing
- enoxaparin
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Canadian Heart Research Centre
Ischemic Stroke, Hemorrhagic Stroke
Cranial Temperature Early Diagnose Hemorrhagic and Ischemic Stroke
The cerebrovascular diseases can be approximately divided as two types, namely ischemic and hemorrhagic stroke. Intravenous thrombolysis within 3-4.5 hours is highly recommended for acute ischemic stroke patients.
- Trial name
- CTedHI (NCT02601183)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Military Medical University
CSA-AKI, Acute Kidney Injury
Discovery and Validation of Biomarkers for CSA-AKI Risk Prediction
This study aims to discover and validate new biomarkers for predicting CSA-AKI before cardiovascular surgery. Nested case-control studies embedded in prospective cohorts.
- Conditions
- CSA-AKI, Acute Kidney Injury, Cardiovascular Surgery, Biomarkers
- Trial name
- NCT07811570
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Syndrome
Identification of Biomarkers in Subjects With Coronary Syndrome (PLAQUE Study)
The study will to test the levels of innovative biomarkers, such as miRNAs, in the blood of subjects underwent to angioplasty procedure according to standard clinical practice.
- Trial name
- PLAQUE (NCT06103357)
- Testing
- blood sample collection
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Acute Heart Failure, Shock
Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock
The relationship between shock, ischemia and reperfusion (I/R) injury, hemodynamic instability, systemic inflammatory response syndrome and multiorgan failure has been extensively investigated, but there is no consensus on the…
- Trial name
- Shockomics (NCT02141607)
- Where
- 3 sites in Belgium, Spain and 1 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shockomics Consortium
Thoracoabdominal Aortic Aneurysm
Investigation of the Cerebrospinal Fluid and Further Tissue Samples for Biomarker Indicating Spinal Ischemia and Organ Failure in Patients With Thoracoabdominal Aortic Aneurysm
Patients with a thoracoabdominal aortic aneurysm in need of an endovascular or open operative restructuring will be asked to participate in this study.
- Trial name
- TAAA (NCT03093857)
- Testing
- Determination of biomarker
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Cardiac Arrest
Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy
A prospective multicenter biomarker study with adult patients treated on intensive care units after out-of-hospital cardiac arrest.
- Trial name
- NCT06471972
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 1,500 people
- Sponsor
- Region Skane
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Cardiovascular Diseases, Atherosclerosis
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Myocardial Infarction
- Trial name
- TAD (NCT00272337)
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Stroke, Ischemic, Large Vessel Occlusion
Biomarkers algOrithm for strOke diagnoSis and Treatment Resistance Prediction
Triage of acute ischemic stroke (AIS) patients is critical, to decrease time to treatment, and improve functional outcome. The therapeutic standard of care for AIS consecutive to large vessel occlusion (LVO) is the association of…
- Trial name
- BOOST (NCT04726839)
- Testing
- Standard of care for stroke management and evaluation of functionnal outcome at 3 months
- Where
- 4 sites in France
- Volunteers
- 3,880 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease
Cardiac Biomarkers After Marathon Running and Coronary Atherosclerosis
This study evaluates cardiac biomarkers and their association to coronary artery disease in marathon runners.
- Trial name
- MaraCat (NCT03738631)
- Where
- Finland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Turku
Fabry Disease
Biomarkers and Cardiac Imaging Diagnostic Assay for Monitoring Patients With Fabry Disease
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by deficient activity of the enzyme α-Gal A resulting from mutations affecting the GLA gene.
- Trial name
- NCT05698901
- Testing
- Agalsidase beta
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Mackay Memorial Hospital
Atrial Fibrillation
Atrial Fibrillation in Relationship to Plasma Biomarkers
The general objective of this study is to: A. To identify novel plasmatic biomarkers associated with prevalent/incident atrial fibrillation in patients with high risk for AF and stroke. B.
- Trial name
- AFISBIO II (NCT04710745)
- Testing
- Peripheral blood samples for routine analysis including NT-proBNP and plasmatic biomarkers., Echocardiography, ECG Holter monitor
- Where
- 6 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Premedix Academy
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