Clinical trials: Cardiovascular Biomarkers
Fabry Disease
Assess Urine Biomarkers to Predict Nephropathy in Fabry Disease
The purpose of this research is to collect biological samples (urine) to develop assays for immune biomarkers to possibly in the future be able to screen subjects with Fabry disease and be able to understand better progression of…
- Trial name
- NCT06065605
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lysosomal and Rare Disorders Research and Treatment Center, Inc.
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Heart Failure
Biomarkers and Therapeutic Modelisation in Heart Failure
The telemonitoring systems for congestive HF did not yet prove their efficacy despite initial encouraging results. Decongestion is one of the main objectives in Congestive HF, but an appropriate titration of diuretics is…
- Trial name
- BIOMIC (NCT01655134)
- Testing
- Blood simples, Capillary punction, Urine simples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Atrial Fibrillation (AF)
Predicting Disease Progression in Atrial Fibrillation: A Multiparametric Approach for Prognostic Marker Identification and Personalized Patient Management
This project leverages artificial intelligence (AI) to decipher Atrial Fibrillation (AF) progression and optimize treatment strategies.
- Trial name
- PAMP FA (NCT06647914)
- Volunteers
- 322 people
- Sponsor
- IRCCS Policlinico S. Donato
Atrial Fibrillation (AF), Atrial Flutter
Detection of Atrial Fibrillation Through Voice Signal Processing
This study is testing a new technology that listens to a person's voice during short phone calls to help identify heart rhythm problems.
- Trial name
- NCT07212816
- Testing
- Sauti
- Volunteers
- 40 people
- Sponsor
- Vital Audio Inc
Cardiovascular Diseases
Exploring the Long-term Cardiovascular Effects of Vaping
Smoking is the "leading, preventable death-cause worldwide", being responsible for almost 700,000 deaths in the E.U. annually. Therefore, implementing successful, long-term smoking cessation strategies is a long-term priority for…
- Trial name
- LIGER (NCT05757934)
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Cardiovascular Disease
A Study Examining Effects of Apples/ Apple Products on Heart Disease Risk
This study will examine if health benefits of consuming nutrient-rich apples, an apple extract and freeze dried apple product will be similar.
- Trial name
- APPS (NCT01585519)
- Testing
- High/ Low Epicatechin Apples/ Apple Extract/ Granules
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Coronary Artery Disease
CorMatrix ECM Study: To Identify Inflammatory Markers Following CABG With/Without ECM
The objective of this study is to identify proteomic inflammatory biomarkers to determine if there are differences in the biomarkers in patients who are treated using the CorMatrix ECM implant to close the pericardium and the…
- Trial name
- CorMatrix (NCT01535807)
- Testing
- CorMatrix extra cellular matrix (ECM)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Inova Health Care Services
Cancer, Solid Tumor
Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms
This study aims to assess biomarkers and their related polymorphisms in the context of cancer-associated thromboembolism, with a particular focus on their interaction with the immune system.
- Conditions
- Cancer, Solid Tumor, Thromboembolism, Cardiovascular Diseases
- Trial name
- CAT_PB (NCT06065592)
- Testing
- Palbociclib, Rivaroxaban, SNP
- Where
- 2 sites in Lebanon
- Volunteers
- 500 people
- Sponsor
- Lebanese University
Psoriasis, Psoriasis Arthritis
A Multi-center RCT Clinical Trial on Personalized Precision Medicine for Patients With Psoriasis and Psoriatic Arthritis and Investigation on Cardiovascular Biomarkers
The inclusion criteria for this study were patients aged 18 to 75 years with a confirmed diagnosis of psoriasis by a dermatologist or psoriatic arthritis by a rheumatologist.
- Conditions
- Psoriasis, Psoriasis Arthritis, Biologics
- Trial name
- SMILE (NCT07149792)
- Testing
- Prescreen platform, biologics treatment
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Coronary Artery Disease
Assessment of Translesional Markers and Metabolomics
Blockages in the blood vessels of the heart are the main cause of chest pain, heart attacks, and sudden death. A cardiac catheterization, or injecting x-ray dye into the blood vessels of the heart and taking pictures, is…
- Trial name
- NCT00321139
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction
Novel Imaging Biomarkers for Mechanical Complications in Acute Myocardial Infarction
Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients.
- Conditions
- Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction, Myocardial Stunning, Myocardial Hemorrhage
- Trial name
- MIRON-RUPTURE (NCT06450912)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rohan Dharmakumar
Heart Failure, Left Bundle-Branch Block
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with increased mortality, more frequent hospitalization…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RECOVER-HF (NCT05769036)
- Testing
- Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Failure
MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY
The MAGIC-HF STUDY project (MAgna GraecIa evaluation of Comorbidities in patients with Heart Failure STUDY), is an observational prevalence and incidence study focusing on the role that risk factors, various comorbidities, and…
- Trial name
- MAGIC-HF (NCT05915364)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Stroke, Atrial Fibrillation
B2AD-Risk AFDAS Evolution of Burden of AF
Each year, 7.8 million people worldwide experience an ischemic stroke, often caused by atrial fibrillation (AF). AF is a major contributor to severe, disabling, and deadly strokes.
- Trial name
- B2AD-Risk AF (NCT06589700)
- Testing
- Implantable Loop Recorder
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Luciano A. Sposato
Diabetic Foot
Negative Pressure Wound Therapy in Diabetic Wounds
Topical Negative Pressure Wound Therapy (TNPW) is an established tool in the management of Diabetic foot ulcer in many countries. This treatment option is under utilized in the public sector of Mauritius.
- Trial name
- NCT05041244
- Testing
- Negative pressure wound therapy delivered through VAC, Standard of care
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- University of Mauritius
Acute Coronary Syndrome, Acute Myocardial Infarction
Switching From Cardiac Troponin I to T
Cardiac troponin is central to the diagnosis of myocardial infarction and high-sensitivity cardiac troponin (hs-cTn) assays are the preferred choice for the assessment of patients with suspected acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Acute Myocardial Ischemia, Myocardial Injury
- Trial name
- TWITCH-ED (NCT05748691)
- Testing
- Clinical implementation of hs-cTnT
- Where
- United Kingdom
- Volunteers
- 26,000 people
- Sponsor
- University of Edinburgh
Wound Infection, Wound Heal
Analytical Performance of pH, HNE and MPO Levels in Detecting Wound Infection Proof of Concept Biomarker Study
The purpose of this study is to evaluate the effectiveness of a novel combination of biomarkers, pH/HNE/MPO, in detecting wound infection using the clinical judgement at 4 weeks as a standard of reference which will include a…
- Trial name
- INDICATE (NCT04979637)
- Sponsor
- ConvaTec Inc.
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