Clinical trials: Cardiovascular Biomarkers
Cardiovascular Diseases, Acute Myocardial Infarction
Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
Coronary heart disease (CHD) is the leading cause of mortality worldwide. Every year, millions of people suffer its most adverse manifestation, an acute myocardial infraction (AMI).
- Conditions
- Cardiovascular Diseases, Acute Myocardial Infarction, Acute Coronary Syndrome, Metabolic Disturbance
- Trial name
- Meta-SMuRF (NCT05494151)
- Testing
- Investigation of the metabolic substrate
- Sponsor
- Aristotle University Of Thessaloniki
Cardiovascular Diseases, Arrythmia
iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease
The Investigators will create a clinical database and a Biobank of stem cells derived from the blood of participants with cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Arrythmia, Cardiomyopathies, Heart Failure
- Trial name
- INFERENCE (NCT06371937)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Ischemic Stroke
Proteomic Study of Chuanhong Zhongfeng Capsule in the Treatment of ACI
Acute cerebral infarction is characterized by high disability rate and high recurrence rate, which poses a great threat to the life and health of the nation.
- Trial name
- NCT06874140
- Testing
- Chuanhong Zhongfeng capsule
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yingyue Ding
Hypertrophic Cardiomyopathy, Acute Coronary Syndrome
Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis
The objective is to determine whether 99Technetium-NC100692 uptake in patients with ACS (MI) can serve as a marker for scar formation as detected by contrast-enhanced MRI during the process of myocardial remodelling after the…
- Trial name
- SCAR (NCT01230918)
- Testing
- 99mTc-NC100692
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Intracerebral Hemorrhage
Biomarkers and Imaging Markers for ICH
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and disability. Basic and clinical research has contributed to our understanding of the complex pathophysiology in ICH.
- Trial name
- NCT06462274
- Testing
- body sample collection and imaging scan
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Southwest Hospital, China
AKI - Acute Kidney Injury, Fluid Balance
Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy
The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury…
- Conditions
- AKI - Acute Kidney Injury, Fluid Balance, Acute Circulatory Failure, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- mVExUS-CRRT (NCT07346118)
- Testing
- mVExUS-guided fluid management
- Where
- 2 sites in Thailand
- Volunteers
- 126 people
- Sponsor
- Chulalongkorn University
Disseminated Intravascular Coagulation
The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation
The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.
- Trial name
- NCT05995093
- Testing
- no intervention
- Where
- China
- Volunteers
- 462 people
- Sponsor
- Qilu Hospital of Shandong University
Stroke, Pneumonia
Pulmonary CT in Pneumonia Complicating Stroke
Pneumonia commonly complicates stroke and has a profound impact on clinical outcomes. Accurate and timely diagnosis of pneumonia complicating stroke remains a major challenge as several issues potentially confound diagnosis.
- Trial name
- NCT03106909
- Testing
- pulmonary computed tomography (CT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Natalie Garratt
Hypoplastic Left Heart, Congenital Heart Disease
Cardiac Biomarkers in Patients With Single Ventricle Physiology
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and…
- Conditions
- Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
- Trial name
- NCT03678909
- Testing
- Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Cardiovascular Disease, Oxidative Stress
Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
The purpose of this project is to determine whether chokeberry polyphenols mitigate cardiovascular disease risk in former smokers.
- Trial name
- NCT01541826
- Testing
- Chokeberry Extract, Chokeberry extract capsule, acute
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Chagas Disease, Chagas Cardiomyopathy
Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evaluation in Chagas Disease Treated Children
Chagas disease (CD) could be acquired by contact with the vector, transplacentally and by blood transfusion. The duration and clinical presentation of the initial acute phase of the infection may be variable, but the majority of…
- Trial name
- NCT04090489
- Where
- Argentina
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Cardiogenic Shock
CardShock Study and Registry
The aim of CardShock Study is to recognise significant prognostic factors in order to detect patients with increased mortality risk to which one could possibly direct more intensive treatments.
- Trial name
- CardShock (NCT01374867)
- Where
- Finland
- Volunteers
- 220 people
- Sponsor
- Helsinki University Central Hospital
Pneumonia, Community-Acquired, COVID-19 Pneumonia
Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.
Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism)…
- Conditions
- Pneumonia, Community-Acquired, COVID-19 Pneumonia, Cardiovascular Diseases
- Trial name
- HOMI-LUNG CAP (NCT06601998)
- Testing
- Blood samples and Oropharyngeal swab, Six-minute walk test, Spirometry, ECG, Heart ultrasound and cardiopulmonary exercise stress testing, Completion of questionnaires of symptoms
- Where
- 18 sites in Greece
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Hellenic Institute for the Study of Sepsis
Hypoxic-Ischemic Encephalopathy
Developmental Outcomes
Determine whether the concentrations of UCH-L1 and GFAP measured in umbilical cord blood and in blood 0-6 hours postnatal accurately predict the extent of neurodevelopmental deficits and/or death at 18-20 months.
- Trial name
- NCT02264808
- Testing
- Developmental Outcomes
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Burns
Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients
Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock.
- Trial name
- CAROLE (NCT03271268)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Breast Cancer
Circulating MicroRNA as Biomarker of Cardiotoxicity in Breast Cancer
In the proposed project the investigators will asses whether changes in expression of selected circulating microRNAs in serum could comprise a sensitive and specific biomarker of cardiotoxicity in cancer patients treated with…
- Trial name
- NCT02065908
- Where
- 3 sites in Poland
- Volunteers
- 128 people
- Sponsor
- West Pomeranian Cancer Center
Cardiac Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT)
The goal of this clinical research study is to learn if certain biomarker testing on blood samples can help to detect heart damage that may occur during chemotherapy.
- Trial name
- NCT01032278
- Testing
- Laboratory Biomarker Analysis, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 597 people
- Sponsor
- M.D. Anderson Cancer Center
Myocardial Infarction
Stem Cell Migratory Activity: Prognostic Marker in Myocardial Ischemia
The present project aims to determine whether a deficit in migration of stem cells could be implicated in the failure to mount an adequate collateralization after Myocardial Infarction (MI) and thereby facilitate the development…
- Trial name
- NCT01271309
- Where
- 2 sites in Italy
- Volunteers
- 170 people
- Sponsor
- IRCCS Multimedica
Hypertension
Prognostic Value of Plasma Biomarkers Among Patients With Hypertension
Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases，and also a substantial public health problem.
- Trial name
- BIOMS-HTN (NCT04107584)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Stroke, Stroke, Ischemic
Quantitative EEG Changes Following Repetitive Transcranial Magnetic Stimulation in Patients With Post Stroke (EEG-rTMS)
Quantitative EEG (qEEG) has been used as an effective tool in the diagnosis and prognosis of brain-related diseases. In the literature, a variety of qEEG parameters have been proven informative in the prognosis of stroke.
- Conditions
- Stroke, Stroke, Ischemic, Stroke/Brain Attack
- Trial name
- EEG-rTMS (NCT05657392)
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS), 32 electrode electroencephalography (EEG)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Katip Celebi University
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