Clinical trials: Cardiovascular Care
Atrial Fibrillation (AF), Coronary Artery Disease
Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation
The goal of this clinical trial is to learn whether the antiarrhythmic drug flecainide can be used as safely as standard rhythm-control drugs in people with atrial fibrillation (AF) and stable coronary artery disease (CAD).
- Trial name
- ReCAST AF (NCT07405671)
- Testing
- flecainide, Sotalol or Amiodarone
- Where
- 14 sites in Belgium
- Volunteers
- 988 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypertension, Cost Effectiveness
Cost-effectiveness of RAMP-HT for Patients With Uncontrolled Hypertension in Hong Kong
Hypertension (HT) is an important risk factor for stroke, coronary heart disease (CHD), heart failure and renal diseases, and the leading risk factor of global disease burden.
- Trial name
- NCT03301194
- Testing
- RAMP-HT
- Where
- Hong Kong
- Volunteers
- 158,322 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Venous Thromboembolism (VTE)
Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)
The purpose of this study is to evaluate whether extended prophylaxis with oral betrixaban can prevent blood clots in the leg and lung that sometime occur in patients hospitalized for an acute medical illness and to compare these…
- Trial name
- APEX (NCT01583218)
- Testing
- Betrixaban, Enoxaparin
- Where
- 462 sites in United States, Argentina and 32 more
- Volunteers
- 7,513 people
- Sponsor
- Portola Pharmaceuticals
Osteoarthritis, Rheumatoid Arthritis
The Standard Care Versus Celecoxib Outcome Trial
The Standard Care versus Celecoxib Outcome Trial (SCOT) is a large streamline safety study designed to compare the cardiovascular safety of celecoxib versus traditional non-selective Non Steroidal Anti-Inflammatory Drug (NSAID)…
- Trial name
- SCOTLSSS (NCT00447759)
- Testing
- Celecoxib, Diclofenac
- Where
- 10 sites in Denmark, Netherlands and 1 more
- Volunteers
- 7,297 people
- Sponsor
- University of Dundee
Lifestyle Intervention, Lifestyle Modification
Effect of Counselling Using Lifestyle Medicine Assessment Tool on Hypertensive Patients
The goal of this clinical trial is to learn if knowing and understanding a patient's daily habits and then giving clear advice on what changes to make can help control blood pressure better than the routine way of advising people…
- Conditions
- Lifestyle Intervention, Lifestyle Modification, Hypertension, Counselling
- Trial name
- NCT07449962
- Testing
- Lifestyle Intervention
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Indus Hospital and Health Network
Cancer, Congenital Heart Disease
Supporting Patient Provider Communication in Paediatric Care
Children with Cancer or congenital heart disease (CHD) experience complex, physical, psychosocial and behavioural symptoms and problems due to the illness, treatment, and medical procedures.
- Trial name
- SiSom (NCT01280227)
- Testing
- SiSom
- Where
- Norway
- Volunteers
- 144 people
- Sponsor
- Oslo University Hospital
Cardiogenic Shock, Bradycardia
Augmented Pacing for Shock in the Cardiac Intensive Care Unit
The goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Bradycardia, Shock
- Trial name
- NCT06713668
- Testing
- Backup Pacing Rate Change
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Diabetic Foot Ulcer, Therapy, Directly Observed
Nocardia Cell Wall Skeleton for the Treatment of Diabetic Foot Ulcer Wounds
This study was to investigate the efficacy and safety of Nocardia rubra Cell Wall Skeleton (NCWS) in the treatment of diabetic foot ulcer wounds. The study was a prospective, randomized, controlled, multicentre study .
- Trial name
- NCT05368142
- Testing
- Nocardia rubra Cell Wall Skeleton, Silver ions dressing
- Volunteers
- 116 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Heart Failure, Medication Optimization
Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver
Numerous pharmacotherapies have been proven to reduce mortality and hospitalization rates for heart failure with reduced ejection fraction (HFrEF) patients.
- Trial name
- NCT07435662
- Testing
- Pharmacy follow up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Denver Health and Hospital Authority
Hypertension
Medication Adherence in Hypertension Study
The purpose of this study is to test an intervention to help older adults do a better job of following blood pressure medication regimens prescribed by their health care providers.
- Trial name
- NCT00688350
- Testing
- Behavioral feedback
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Depression, Hypertension
Strengthening Mental Health Care in Chronic Care Patients With Hypertension. A Cluster Randomised Control Trial
A pragmatic cluster randomized controlled trial (RCT) in 20 public sector primary care clinics in the Dr Kenneth Kaunda district of the North West Province of South Africa to assess mental health and health outcomes for depressed…
- Trial name
- NCT02425124
- Testing
- PC101+Mental Health
- Where
- South Africa
- Volunteers
- 1,052 people
- Sponsor
- University of KwaZulu
Heart Failure
Home Based Intervention Led by Nurse in Brazil
Home visits (HV) are one of the multidisciplinary approaches that has already shown to benefit the follow-up of Heart Failure (HF) patients.
- Trial name
- HFHELENI (NCT01213862)
- Testing
- Home Based Education
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA
In the United States, the growing Hispanic/Latino population is at high risk for type 2 diabetes and associated complications, yet underserved in healthcare and underrepresented in research.
- Trial name
- NCT05000840
- Testing
- Enrollment in existing SDRI diabetes education programs
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Sansum Diabetes Research Institute
Acute Coronary Syndrome
Pre-hospital Rule-out of Acute Coronary Syndrome
Patients with chest pain suspected for non ST-segment elevation acute coronary syndrome (NSTE-ACS) are routinely transferred to the emergency department (ED).
- Trial name
- ARTICA (NCT05466591)
- Testing
- Pre-hospital rule-out strategy
- Where
- Netherlands
- Volunteers
- 866 people
- Sponsor
- Radboud University Medical Center
Out-of-hospital Cardiac Arrest
German Cardiac Arrest Registry
In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes.
- Trial name
- G-CAR (NCT05142124)
- Where
- 25 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Leipzig Heart Science gGmbH
Acute Ischemic Stroke
Quality Assessment in Acute Stroke Care
The purpose of the study is to evaluate the quality of care on a 16 bed stroke unit by using a new developed clinical pathway.
- Trial name
- QuASt (NCT00574262)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Muenster
Circulatory Failure, Shock State
Fluid Responsiveness Assessment in Children
Fluid responsiveness assessment is a major issue in intensive care. Since fewer fluid responsiveness tests can be used children, fluid expansion prescriptions are often based on professional practices due to the absence of…
- Trial name
- FRAICHE (NCT07073859)
- Testing
- Fluid expansion
- Where
- 31 sites in France
- Volunteers
- 513 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Thromboembolism
Thromboembolic Events in Severe COVID-19 Patients
The main objective of this study is to describe the incidence of thromboembolic events in a population of patients hospitalized in intensive care units in France for severe COVID-19.
- Trial name
- COVICLOT (NCT04405869)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Artery Disease, Myocardial Revascularization
Nursing Intervention for Adaptation After Myocardial Revascularization
Introduction: Myocardial revascularization is an essential procedure for patients with cardiovascular disease. Its recovery in the outpatient setting involves significant challenges for both the patient and the caregiver.
- Conditions
- Coronary Artery Disease, Myocardial Revascularization, Postoperative Recovery After Cardiac Surgery, Nursing Care
- Trial name
- ADAPT-CABG (NCT07576569)
- Testing
- Nursing Intervention Program, Usual Care
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Universidad de la Sabana
Lower Extremity Chronic Ulcers in Diabetics
Evaluation of CureXcell® in Treating Lower Extremity Chronic Ulcers in Adults With Diabetes
Chronic foot ulcers are particularly prevalent in patients with underlying diabetes mellitus. These ulcers are reported to be the leading cause of hospitalization among people with diabetes.
- Trial name
- NCT01421966
- Testing
- CureXcell®
- Where
- 37 sites in United States, Canada and 1 more
- Volunteers
- 285 people
- Sponsor
- Macrocure Ltd.