Clinical trials: Cardiovascular Complications
Diabetic Foot Ulcer, Non-healing Diabetic Foot Ulcer
EPC Silver Wound Gel (EPC-123) Feasibility Study in the Management of Mildly Infected Diabetic Foot Ulcers
The objective of this single-arm feasibility study is to investigate the safety and impact of the topical EPC Silver Wound Gel (EPC-123) in the management of diabetic foot ulcer wounds not progressing under the current standard…
- Conditions
- Diabetic Foot Ulcer, Non-healing Diabetic Foot Ulcer, Diabetic Foot Infection
- Trial name
- NCT05243810
- Testing
- EPC Silver Wound Gel
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Exciton Technologies Inc.
Healthy Pregnant Women, Obese Pregnant Women
Pregnancy Cohort Study: Pregnancy as a Window to Future Health
The goal of this observational cohort study is to gain deep insights into how metabolic disorders such as obesity or diabetes during pregnancy affect the metabolic and cardiovascular health of mother and child in the short and…
- Conditions
- Healthy Pregnant Women, Obese Pregnant Women, Gestational Diabetes
- Trial name
- PregWin (NCT06925815)
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Hypertension in Pregnancy
The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Hypertensive disorders of pregnancy, include pre-existing and gestational hypertension, preeclampsia, and eclampsia, it complicates up to 10% of pregnancies and represents a significant cause of maternal and perinatal morbidity…
- Trial name
- NCT05673135
- Testing
- Anti-Hypertensive, Ultrasound, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Assiut University
Diabetic Foot Ulcer
Negative Pressure Wound Therapy in the Management of Diabetic Foot Ulcers
Role of Negative Pressure Wound Therapy in the Management of Diabetic Foot Ulcers The aim of this study will be to assess negative pressure wound therapy in treating diabetic foot ulcers.
- Trial name
- NCT04093635
- Testing
- Negative Pressure Wound Therapy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Hemorrhoid
Subarachnoid or Infiltration for Hemorrhoidectomy
There will be compared the postoperative analgesic effect of infiltration or spinal block for hemorrhoidectomy
- Trial name
- NCT01927874
- Testing
- Infiltration, Spinal block, Bupivacaine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Diabetic Foot
a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis
Osteomyelitis is a frequent complication of diabetic foot ulcer. Several therapeutic strategies are used : medical treatment with antibiotics and foot offloading or surgical treatment consisting in the resection of infected bone…
- Trial name
- DIPIOS (NCT00578890)
- Testing
- Medical/surgical treatment versus medical treatment
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Vein Thrombosis, Bypass Complication
Post-Market Clinical Follow-up Study with ASPIREX®S to Assess the Safety and Effectiveness in the Treatment of DVT
The ASPIREX®S Endovascular System is a rotating and aspirating catheter system. It is intended to be used for the percutaneous transluminal removal of fresh thrombotic or thromboembolic material from native blood vessels (or…
- Conditions
- Deep Vein Thrombosis, Bypass Complication, Dialysis Shunt, Stent Occlusion
- Trial name
- P-MAX (NCT03116750)
- Where
- 9 sites in Austria, France and 3 more
- Volunteers
- 81 people
- Sponsor
- Straub Medical AG
Endoleak After Endovascular Aneurysm Repair
Multicentre Trial Of Serum Levels Of MMP-9 As A Biomarker Of Endoleak
Endovascular procedures already brought enormous revolution in the process of treatment of patient with abdominal aortic aneurysm (AAA).
- Trial name
- BIOLEAK (NCT01965717)
- Where
- Serbia
- Volunteers
- 65 people
- Sponsor
- Igor Koncar
Diabetic Retinopathy
Automated AI-based System for Early Diagnosis of Diabetic Retinopathy
In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR)in the primary care, optometrist…
- Trial name
- NCT05324189
- Testing
- Referable versus Non Referable Diabetic Retinopathy diagnostic test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG)
Effect of Cardiovascular Autonomic Neuropathy on AKI and Outcomes in Isolated CABG Surgery
This study aims to investigate the effects of Cardiovascular Autonomic Neuropathy (CAN) on Acute Kidney Injury (AKI) and clinical outcomes in patients undergoing isolated Coronary Artery Bypass Graft (CABG) surgery requiring…
- Conditions
- Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG), Cardiovascular Autonomic Neuropathy (CAN), Postoperative Outcomes
- Trial name
- CAN-AKI-CABG (NCT07254468)
- Where
- Turkey (Türkiye)
- Volunteers
- 912 people
- Sponsor
- Akdeniz University
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Kidney Failure, Hemodialysis
SGLT2 Inhibition in Hemodialysis
Dapagliflozin will be compared with placebo to evaluate its effects on cardiac structure and safety in patients with kidney failure receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Hemodialysis, Diabetes Mellitus, Type 2, Chronic Kidney Disease
- Trial name
- DAPA-HD (NCT05179668)
- Testing
- Dapagliflozin 10 MG
- Where
- 9 sites in Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Bladder Carcinoma, Breast Cancer
T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies
Background: Autologous T cells engineered to express a T cell receptor (TCR) targeting NY-ESO-1 will be infused back to patients with NY-ESO-1- expressing malignancies.
- Conditions
- Bladder Carcinoma, Breast Cancer, Esophagus Carcinoma, Lung Cancer
- Trial name
- NCT02457650
- Testing
- Cyclophosphamide, Fludarabine, Anti-NY ESO-1 TCR-transduced T cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shenzhen Second People's Hospital
Atrial Fibrillation, Postoperative Complications
Landiolol for Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery with incidences ranging from 20% to 40% with the consequence of increasing mortality, morbidity, and hospital length of stay, as well as…
- Trial name
- LANDI-POAF (NCT05084118)
- Testing
- Landiolol HCl
- Where
- Austria
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy, Type 2 Diabetes
Enriched Eggs for Retina Health in Type 2 Diabetes
Diabetes mellitus has been declared a major public health issue. Among the complications of the disease, retinopathy can have a significant impact on mobility and quality of life for individuals living with diabetes.
- Trial name
- NCT04496817
- Testing
- Docosahexaenoic Acid and Lutein Enriched Eggs, Regular Eggs
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Anemia, Non-Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the maintenance treatment of anemia in participants with Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
- Trial name
- NCT02680574
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 503 sites in United States, Argentina and 28 more
- Volunteers
- 1,725 people
- Sponsor
- Akebia Therapeutics
Myocardial Reperfusion Injury
Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI
Percutaneous coronary intervention (PCI) for acute coronary syndromes frequently fails to restore myocardial perfusion despite establishing epicardial vessel patency.
- Trial name
- BQ-123 (NCT00586820)
- Testing
- BQ-123
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Diabetic Retinopathy
Progression of Diabetic Retinopathy. Identification of Signs and Surrogate Outcomes
Progression of Diabetic Retinopathy. Identification of Signs and Surrogate outcomes (PROGRESS)
- Trial name
- PROGRESS (NCT03010397)
- Where
- Portugal
- Volunteers
- 212 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Macular Edema (DME)
Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-03)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with diabetic macular edema (DME).
- Trial name
- GOBI (NCT07842016)
- Testing
- OLN324, Aflibercept
- Volunteers
- 450 people
- Sponsor
- Ollin Biosciences, Inc.
Acute Kidney Injury
Stockholm Acute Kidney Injury Cohort
Since 2009, adult patients with acute kindney injury (AKI) at the department of Nephrology, Danderyd University Hospital and Karolinska Institutet, have been included in a prospective cohort.
- Trial name
- SAKIS (NCT05111535)
- Where
- 2 sites in Sweden
- Volunteers
- 1,861 people
- Sponsor
- Danderyd Hospital
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