Clinical trials: Cardiovascular Condition
Aortic Stenosis
Deep Learning Enhanced Detection of Aortic Stenosis - The DETECT-AS-Diagnostic Study
The DETECT-AS Diagnostic Study will assess the performance of artificial intelligence (AI) risk predictions to detect aortic stenosis using results from portable electrocardiogram (ECG) and cardiac ultrasound devices.
- Trial name
- NCT06749145
- Testing
- Portable 1-lead electrocardiogram, Point-of-care ultrasound, AI-ECG risk algorithm
- Where
- 3 sites in United States
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Foot
Autologous Endothelial Progenitor Cells Treatment of Diabetic Foot
The vascular pathologic basis of diabetic foot include arterial obstruction and micro-circulation defects.The latest technology of arterial reconstruction can only rebuild blood flow of anterior,posterior tibial artery and…
- Trial name
- NCT02474381
- Testing
- EPCs plus PTA, Single PTA
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Cardiovascular Diseases, Periodontal Diseases
Association of Asprosin in Periodontitis and Acute Coronary Syndrome
Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc.
- Trial name
- NCT05647902
- Testing
- Serum samples will be collected. Asprosin levels will be determined by biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Stroke Sequelae, Gait, Hemiplegic
ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)
Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation.
- Trial name
- ACTUAL (NCT06061601)
- Testing
- Exoskeleton stroke group
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Heart Diseases, Microbial Colonization
Dairy Fat and Fermentation Study
The purpose of the study is to compare the effect of consuming full-fat (regular) and fat-free (skim) milk, as well as full-fat and fat-free yogurt (a fermented dairy product), on microorganisms in your gut as well as the…
- Conditions
- Heart Diseases, Microbial Colonization, Inflammation
- Trial name
- NCT05840081
- Testing
- Milk or yogurt beverage
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tufts University
Overweight and Obesity, Cardiovascular Diseases
Study Consortium for Evaluation of RNPC Program in Obese and Overweight Patients (SCOOP-RNPC)
The investigators hypothesize that weight loss obtained with the French RNPC weight reduction program is beneficial for the general health of overweight/obese patients in the medium term.
- Conditions
- Overweight and Obesity, Cardiovascular Diseases, Metabolic Disease, Diabete Type 2
- Trial name
- SCOOP-RNPC (NCT05857319)
- Testing
- Nutritional Psycho-Behavioral Reeducation Program
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Groupe Éthique et Santé
Peripheral Arterial Disease
Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease
The fatty acid composition of canola oil will have beneficial acute and chronic effects on vascular function in individuals with peripheral arterial disease.
- Trial name
- NCT01250275
- Testing
- traditional canola oil, high oleic canola oil, soybean oil
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cerebral Ischemia
A Prospective Study of a New Device for Monitoring Cerebral Oxygenation on Healthy Volunteers
The purpose of this study is to determine whether a new cerebral oxygen monitoring device is effective and comparatively similar to the current approved devices.
- Trial name
- NCT00598819
- Testing
- CDI 1000 COM
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Posttraumatic Stress Disorder, Insomnia
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
This pilot pre-post trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia, sleep difficulties that remain after successful treatment of…
- Conditions
- Posttraumatic Stress Disorder, Insomnia, Cardiovascular Diseases, Metabolic Disease
- Trial name
- NCT05516277
- Testing
- Behavioral Sleep Education Intervention
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Atherosclerosis, Diet Modification
Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity
Recently, the investigators have been screening for anti-atherogenic or pro-atherogenic amino acids (AAs) in the macrophage model system to better understand their role in atherogenesis.
- Conditions
- Atherosclerosis, Diet Modification, Serum; Disease
- Trial name
- NCT03180775
- Testing
- Cellulose (control), Glycine, Alanine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Stroke
Upper Limb Movement Quality Following Stroke
The aim of this study is to monitor the daily upper limb movement of persons with stroke, and to relate these quantities to measures of recovery and impairment.
- Trial name
- NCT06497881
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adi Negev-Nahalat Eran
Surgery, Cardiac Death
Endothelial Dysfunction and Non-cardiac Surgery
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
- Conditions
- Surgery, Cardiac Death, Stroke, Myocardial Injury
- Trial name
- NCT05778981
- Testing
- FMD - Troponin measurement
- Where
- Chile
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chile
Eating Attitudes, Lifestyle Risk Reduction
Eating, Sleep, Attitudes, and Stress Risk in Physical Therapy Students
The goal of this observational study is to assess how eating attitudes, sleep attitudes, and perceived stress contribute to early indicators of cardiovascular risk among undergraduate physical therapy students aged 18-30.
- Conditions
- Eating Attitudes, Lifestyle Risk Reduction, Perceived Stress
- Trial name
- EHSAR-S (NCT07303244)
- Testing
- complete validated questionnaires
- Where
- Egypt
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Cairo University
Congestive Heart Failure
Study to Evaluate the Effect of SLV320 in Addition to Chronic Furosemide Treatment on Renal Function in Subjects With Congestive Heart Failure and Impaired Renal Function
This is a randomized, double-blind, placebo-controlled, multi-center, sequential cohort study in subjects with congestive heart failure (CHF) and impaired renal function who are on stable furosemide treatment (³ 40 mg daily).
- Trial name
- NCT00568009
- Testing
- SLV320
- Where
- 72 sites in United States, Argentina and 8 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Healthy, Stress, Psychological
Study of Physical Health for Women With Posttraumatic Stress or Depression
The purpose of this study is to obtain a better understanding of how stress is related to health risks.
- Conditions
- Healthy, Stress, Psychological, Depression, Posttraumatic Stress Disorders
- Trial name
- NCT01208844
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Heart Failure
Risk-guided Disease Management Plan to Prevent Heart Failure in Patients Treated With Previous Chemotherapy (REDEEM)
This is a prospective study in which a process of identifying and reducing heart failure (HF) risk will be applied to cancer survivors >55 years old with chemotherapy >5 years ago.
- Trial name
- NCT04962711
- Testing
- Heart Failure intervention (Cardio-Oncology Disease Management Plan (CO-DMP), Usual care
- Where
- Australia
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension
An Artificial Intelligence-Assisted Digital Health Lifestyle Intervention for Adults With Hypertension
This study evaluates the impact of a fully digital, autonomous, and artificial intelligence (AI)-driven lifestyle coaching program on managing blood pressure (BP) among adults diagnosed with hypertension.
- Trial name
- NCT06337734
- Testing
- AI-Driven Lifestyle Coaching Program
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Atherosclerosis, Cardiovascular Diseases
Coffee Consumption and Coronary Artery Calcium Score
Coffee is one of the dietary factors associated with cardiovascular disease (CVD) but its role in the cardiovascular system is not yet clear.
- Trial name
- NCT03139071
- Where
- Brazil
- Volunteers
- 4,426 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
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