Clinical trials: Cardiovascular Condition
ATTR-CM (Transthyretin Amyloid Cardiomyopathy), Heart Failure
Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis
People eligible for this study have had the suggestion from their doctor to receive a cardiac pacemaker or defibrillator to treat a cardiac condition as part of their routine care.
- Trial name
- RV-CAM (NCT07784712)
- Volunteers
- 70 people
- Sponsor
- Geisinger Clinic
Atrial Fibrillation
Atrial Fibrillation Algorithms Clinical Validation Study
The purpose of the study is to evaluate the performances of investigational Irregular Rhythm Notification Feature (version 2.0) and Atrial Fibrillation History Feature algorithms.
- Trial name
- NCT04699812
- Testing
- ELECTROCARDIOGRAM (ECG) PATCH WEAR
- Where
- 4 sites in United States
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Coronary Artery Disease
Customizable Respiratory Exercise Device in Individuals Who Have Undergone Cardiac Surgery
The cardiorespiratory system integrates systemic and pulmonary circulation while ensuring adequate oxygenation of the body at rest and during exercise.
- Trial name
- NCT06258681
- Testing
- Incentive spirometer, Individualized respiratory training group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Biruni University
Cardiac Arrest, Frailty
The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation
The aim of this study was to determine the independent association of frailty with cardiopulmonary resuscitation and predictive factors in patients triggering code blue response
- Conditions
- Cardiac Arrest, Frailty, Respiratory Arrest
- Trial name
- NCT06405581
- Testing
- Edmonton frailty scale calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Umraniye Education and Research Hospital
Neurologic Manifestations, Psychiatric Disorders
Cohort of Patients With Covid-19 Presenting Neurological or Psychiatric Disorders (CoCo-Neurosciences)
Covid-19 pandemic now affects more than two million people worldwide. The neurotropism of the virus is assumed by its frequent association with neurological symptoms (anosmia, ageusia, headaches) but the extent of the central or…
- Conditions
- Neurologic Manifestations, Psychiatric Disorders, COVID-19
- Trial name
- CoCo-Neuro (NCT04362930)
- Where
- France
- Volunteers
- 730 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Endothelial Function
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and…
- Trial name
- HYPER-endoEV-a (NCT07728630)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
Near INfrared Spectroscopy in Aortic valvE ReplacemenT
Transcatheter aortic valve implantation (TAVI) is an alternative for patients, that are considered to be too sick for conventional aortic valve replacement.
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation, Eligibility for Both Anaesthetic Methods
- Trial name
- INSERT (NCT01251328)
- Testing
- General anaesthesia, Sedation
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Heart Failure With Preserved Ejection Fraction
The Impact of Exercise Training on Functional Capacity in Heart Failure
The purpose of this study is to determine whether exercise training will improve functional capacity in patients with heart failure and preserved ejection fraction.
- Trial name
- NCT01288365
- Testing
- Exercise training
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Meir Medical Center
Intracranial Aneurysm
Safety and Efficacy of Neuroform3TM for Intracranial Aneurysm Treatment
This is a prospective observational multicenter registry to evaluate safety and efficacy data on Neuroform3TM stenting for treatment with endovascular coiling of wide neck aneurysms on an intent to treat basis.
- Trial name
- SENAT (NCT00928265)
- Testing
- Endovascular treatment of intracranial aneurysm.
- Where
- 12 sites in France
- Volunteers
- 116 people
- Sponsor
- Stryker Neurovascular
Coronary Artery Disease
Trans-Radial Coronary Interventions Using A Sheathless Guiding Catheter
Background: The transradial approach is increasingly used in percutaneous coronary intervention (PCI) because of lower major access site complications, lower bleeding risk and earlier patient mobilization.
- Trial name
- Sheathless-TRI (NCT01327365)
- Testing
- trans-radial PCI (TRI)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Hospital, Geneva
Cardiovascular Diseases, Heart Diseases
Diet Modification and Blood Pressure in Young People
To determine the effects of diet modification on blood pressure, blood cholesterol, and bone density in healthy young people.
- Trial name
- NCT00005167
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
Evaluation of the CIRCA Monitoring System in Prevention of Esophageal Lesions Following RFCA
The purpose of this study is to determine if the use of Circa™ temperature monitoring system during ablation procedures will reduce the risk of esophageal lesions or damage.
- Trial name
- CIRCA-EGD (NCT02467166)
- Testing
- Circa™ Probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Acute Myocardial Infarction
Cell Therapy in Myocardial Infarction
The purpose of this study is to determine cell therapy efficacy in patients with ST elevation acute myocardial infarction (STEMI)
- Trial name
- EMRTCC (NCT00350766)
- Testing
- Autologous Bone Marrow Mononuclear Cells (ABMMC) Transplantation
- Where
- Brazil
- Volunteers
- 166 people
- Sponsor
- Ministry of Health, Brazil
Multiple Myeloma
Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients
This is a multicenter, open label clinical trial evaluating the safety of the combination of belantamab mafodotin + the combination treatment VRd (bortezomib, lenalidomide, dexamethasone) in newly diagnosed (ND) transplant…
- Trial name
- NCT04802356
- Testing
- Belantamab mafodotin, Bortezomib, Lenalidomide
- Where
- 12 sites in Spain
- Volunteers
- 50 people
- Sponsor
- PETHEMA Foundation
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Stroke
Efficacy of Assistive Soft Gloves in Chronic Stroke Rehabilitation
Stroke is a leading cause of disability, with hemiparesis affecting approximately 85% of survivors, particularly affecting the upper limbs, which play a critical role in the activities of daily living (ADLs).
- Trial name
- NCT07327151
- Testing
- Sybero SRGs, Occupational therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kocaeli University
Coronary Artery Disease
Intravascular Identification and Drug-Eluting Balloon Treatment of Vulnerable Lipid-Rich Plaques
Rationale: Two-thirds of intracoronary thrombi causing acute coronary syndrome (ACS) result from rupture of lipid-rich plaques (LRP).
- Trial name
- DEBuT-LRP (NCT04765956)
- Testing
- Drug-eluting balloon treatment
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Age-related Macular Degeneration, Coronary Artery Disease
Age-related Macular Degeneration (AMD) and Cardiovascular Disease
The purpose of this research study is to investigate the link between age-related macular degeneration (AMD or ARMD) and coronary artery disease (CAD).
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT04087356
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The New York Eye & Ear Infirmary
Coronary Disease, Coronary Artery Disease
Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries
The purpose of this study is to demonstrate the safety and efficacy of the ZoMaxx drug-eluting stent in patients with blockage of native coronary arteries.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ZoMaxx™ I (NCT00148356)
- Testing
- ZoMaxx™ Drug-Eluting Coronary Stent System, TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent System
- Where
- 29 sites in Australia, Belgium and 8 more
- Volunteers
- 401 people
- Sponsor
- Abbott Medical Devices
Hypertension, Diabetes
Genetics of Type 2 Diabetes in West Africans
Background: Type 2 diabetes (T2D) and associated complications are major contributors to the global disease burden. T2D is already a major health threat in populations in developed countries and is rapidly taking hold in the…
- Trial name
- NCT00837122
- Where
- 5 sites in Ghana, Nigeria
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
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