Clinical trials: Cardiovascular Condition
Macular Edema, Central Retinal Vein Occlusion
Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)
The purpose of this study is to compare visual improvement and total number of intraocular injections in eyes with macular edema following central retinal vein occlusion (CRVO)after initial treatment with Ozurdex (dexamethasone…
- Trial name
- NCT01231633
- Testing
- Ozurdex, Avastin
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Long Island Vitreoretinal Consultants
Cardiovascular Diseases, Vascular Dilation
Thromboxane Receptor Antagonist to Improve Endothelial Function
This study evaluates whether addition of the thromboxane receptor antagonist to chronic aspirin therapy improves endothelial function and reduces non-platelet thromboxane generation in patients with established cardiovascular…
- Trial name
- TRAP (NCT03962855)
- Testing
- Ifetroban Sodium
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Jeffrey Rade
Thoracoabdominal Aneurysm, Abdominal Aortic Aneurysm
Endovascular Exclusion of TAAA/AAA Utilizing Fenestrated/Branched Stent Grafts
The purpose of the study is to evaluate the role of fenestrated/branched stent-grafts in the exclusion of abdominal aortic and thoracoabdominal aneurysms.
- Trial name
- NCT00583050
- Testing
- Endovascular Aneurysm Repair
- Where
- United States
- Volunteers
- 1,366 people
- Sponsor
- The Cleveland Clinic
Hypertension
Safety and Efficacy of MK0736 & MK0916 in Patients With Hypertension (High Blood Pressure)(0736-003)(COMPLETED)
The objective of this study is to evaluate the safety and efficacy of two investigational drugs (MK-0736 and MK-0916) in lowering blood pressure and body weight in patients with hypertension (high blood pressure).
- Trial name
- NCT00274716
- Testing
- MK0736, MK0916
- Volunteers
- 249 people
- Sponsor
- Merck Sharp & Dohme LLC
Critical Limb Ischemia, Peripheral Arterial Disease
IN.PACT BTK Randomized Study to Assess Safety and Efficacy of IN.PACT 014 vs. PTA
To assess the safety and efficacy of the paclitaxel drug-coated balloon IN.PACT 014 versus conventional optimal percutaneous transluminal angioplasty (PTA) for the treatment of patients with chronic total occlusions in the…
- Trial name
- NCT02963649
- Testing
- DCB, PTA
- Where
- 9 sites in Belgium, France and 3 more
- Volunteers
- 50 people
- Sponsor
- Medtronic Endovascular
Pulmonary Hypertension
Evaluation of a New 6 Minute Walk Test Smartphone App in Patients With Pulmonary Hypertension
Comparison of standard 6 minute walk test with 6 minute walk test smartphone app.
- Trial name
- 6-APP (NCT04633538)
- Testing
- 6MWT smartphone app
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Ischemic Stroke
A Phase Ib/II in Patients With Acute Ischemic Stroke
Stroke is the fifth leading cause of death in the United States and is the leading cause of long term disability. Distinct geographic disparities in stroke mortality, with highest rates in the southeast United States including…
- Trial name
- NCT02963376
- Testing
- 0.05 mL/kg DDFPe, 0.10 mL/kg DDFPe, 0.17 mL/kg DDFPe
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NuvOx LLC
Coronary Artery Disease
Cardiac Home Education and Support Trial (CHEST): A Pilot Study
Coronary artery bypass graft (CABG) surgery is performed more frequently on individuals who are older and sicker than in previous years.
- Trial name
- NCT00275340
- Testing
- Peer Support
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- University of Toronto
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypertensive Urgency
Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department
The purpose of this study is to compare the safety and efficacy of Cardene I.V. to labetalol administered intravenously for the management of hypertension in the emergency department setting.
- Trial name
- CLUE (NCT00765648)
- Testing
- nicardipine intravenous, Labetalol
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- The Cleveland Clinic
Waldenstrom's Macroglobulinemia
Study of the Combination of Bortezomib, Dexamethasone, and Rituximab in Patients With Waldenstroms Macroglobulinemia
The purpose of this study is to find out if the combination of bortezomib (Velcade), dexamethasone (Decadron) and rituximab (Rituxan) is effective in treating Waldenstrom's macroglobulinemia.
- Trial name
- NCT00250926
- Testing
- Bortezomib, Dexamethasone, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Lymphoid Malignancies, Lymphoma
Romidepsin Plus Oral 5-Azacitidine in Relapsed/Refractory Lymphoid Malignancies
This is an open label, phase I/IIa, 3 x 3 dose escalation study with an initial phase I followed by a disease focused phase II. The primary objective of the phase I is to determine the maximum tolerated dose (MTD) and dose…
- Conditions
- Lymphoid Malignancies, Lymphoma, Hodgkin Lymphoma, Non-hodgkin Lymphoma
- Trial name
- NCT01998035
- Testing
- RomiDEPsin 10 MG/M2, Oral 5-Azacitidine 100 MG, Romidepsin 14 MG/M2
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Myocardial Infarction
Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)
Patients with partially blocked blood vessel(s) in their heart may need a medical procedure called "Percutaneous Coronary Intervention (PCI)" to open the narrowed blood vessel(s).
- Trial name
- NCT02939976
- Testing
- Single Vessel Disease, Multi-vessel Disease, Culprit Vessel Only, Multi-vessel Disease, Complete Revascularization
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- David Kong, M.D.
Pulmonary Arterial Hypertension
EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension
This was a multicenter, open-label study to evaluate the dose of Orenitram® (treprostinil) Extended Release Tablets achieved at 16 weeks after a short-term course of Remodulin® (treprostinil) Injection in subjects with pulmonary…
- Trial name
- NCT03497689
- Testing
- Intravenous/Subcutaneous Treprostinil; Oral Treprostinil
- Where
- 11 sites in United States
- Volunteers
- 36 people
- Sponsor
- United Therapeutics
Out-Of-Hospital Cardiac Arrest
Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
In this clinical study, a total of 1500 patients with out-of-hospital cardiac arrest in Seattle/King County will be enrolled. This will be a randomized clinical trial and patients will receive either two different doses of IV…
- Trial name
- SNOCAT (NCT03452917)
- Testing
- sodium nitrite 45 mg, sodium nitrite 60 mg
- Where
- United States
- Volunteers
- 1,502 people
- Sponsor
- University of Washington
Atherosclerosis
Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial
Atherosclerotic disease, or hardening of the arteries, is characterized by the thickening of the arterial walls due to fatty deposits in wall and inflammation in the wall of arteries.
- Trial name
- NCT02169089
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University Hospitals Cleveland Medical Center
Cerebrovascular Accident, Hemiplegia
Post Stroke Hand Functions: Bilateral Movements and Electrical Stimulation Treatments
The purpose of this study was to determine the effect of two amounts of treatment therapy on post stroke motor recovery in the arms.
- Trial name
- NCT00369668
- Testing
- Bilateral movements and neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Multiple Myeloma, Non-Hodgkin Lymphoma
Preservation of Ovarian Function After Hematopoietic Cell Transplant
Women undergoing myeloablative allogeneic hematopoietic cell transplant (MA HCT) will receive GnRH agonist leuprolide. Women undergoing reduced intensity allogeneic (RIC) HCT will be observed.
- Conditions
- Multiple Myeloma, Non-Hodgkin Lymphoma, Hodgkin Disease, Acute Myeloid Leukemia
- Trial name
- NCT01343368
- Testing
- Leuprolide, hematopoietic cell transplant, reduced intensity allogeneic HCT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Alagille Syndrome
An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome (ALGS)
The purpose of this extension study is to determine the long-term safety and tolerability of an investigational treatment (LUM001 also known as Maralixibat) in children with ALGS who have completed participation in a core LUM001…
- Trial name
- IMAGINE (NCT02047318)
- Testing
- LUM001 (Maralixibat)
- Where
- 3 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Heart Failure
A Study of Ponsegromab in People With Heart Failure
The primary purpose of this clinical trial is to compare the effects of study medicine (Ponsegromab/PF-06946860) with a placebo (an injection that looks like the study medicine but does not contain the active medicine) to find…
- Trial name
- GARDEN TIMI 74 (NCT05492500)
- Testing
- Main cohort (Cohort A): Ponsegromab low dose, Main cohort (Cohort A): Ponsegromab medium dose, Main cohort (Cohort A): ponsegromab high dose
- Where
- 122 sites in United States, Australia and 9 more
- Volunteers
- 455 people
- Sponsor
- Pfizer
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