Clinical trials: Cardiovascular Condition
Dementia, Alzheimer Disease
A Longitudinal Multidimensional Population Study on Brain Aging
Longitudinal observational study of cognitive functions, physical health and biological parameters in the whole population living in Abbiategrasso born between 1935 and 1939,1773 subjects, followed for six years in order to know…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- InveCeAb (NCT01345110)
- Where
- Italy
- Volunteers
- 1,321 people
- Sponsor
- Fondazione Golgi Cenci
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Usability and Tolerability of the Norditropin NordiFlex® Injection Device in Children Never Previously Treated With Growth Hormone
This study is conducted in Europe. The purpose of this study is to assess the impact on daily life for children new to using a growth hormone injection device.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Genetic Disorder, Turner Syndrome
- Trial name
- NCT01327924
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Novo Nordisk A/S
Heart Failure, Heart Diseases
Flexible vs. Fixed Diuretic Regimen in the Management of Chronic Heart Failure: A Pilot Study
Heart failure is a major cause of death and hospitalization in Canada. Many of the symptoms experienced by patients with heart failure relate to having fluid accumulate in the lungs causing difficulty breathing, swelling in the…
- Trial name
- NCT05594823
- Testing
- Ambulatory heart failure management with Flexible Diuretic Regimen with furosemide, Ambulatory heart failure management with fixed dose furosemide
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
22q11.2 Deletion Syndrome, Velo-Cardio-Facial Syndrome
Cognitive Remediation in 22q11DS
The goal of this study is to collect preliminary data on the efficacy of a cognitive remediation program in improving the neurocognitive deficits in children with chromosome 22q11.2 deletion syndrome (22q11DS).
- Trial name
- NCT01781923
- Testing
- Cognitive remediation program, Small group social skills training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Congenital Heart Disease, Heart Valve Disease
Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery
Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft.
- Trial name
- NCT01653223
- Testing
- simvastatin
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Sun Yat-sen University
Aortic Regurgitation, Aortic Valve Insufficiency
ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™
To demonstrate non-inferiority of the Trilogy Transcatheter Heart Valve (THV) System compared with surgical aortic valve replacement (SAVR) for treatment of subjects with clinically significant native aortic regurgitation (AR)
- Conditions
- Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency
- Trial name
- ARTIST (NCT06608823)
- Testing
- Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR
- Where
- 40 sites in United States
- Volunteers
- 1,016 people
- Sponsor
- JenaValve Technology, Inc.
Turner Syndrome
The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome
The purposes of this study are to learn whether treatment with an androgen type hormone will improve the visual-spatial problems associated with Turner syndrome, and to evaluate the effect growth hormone, with and without…
- Trial name
- NCT00029159
- Testing
- estrogen, androgen
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Non-exudative Age-related Macular Degeneration, Diabetic Retinopathy
Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy
This pilot study is to determine whether it would be safe and feasible to inject CD34+ stem cells from bone marrow into the eye as treatment for patients who are irreversibly blind from various retinal conditions.
- Conditions
- Non-exudative Age-related Macular Degeneration, Diabetic Retinopathy, Retina Vein Occlusion, Retinitis Pigmentosa
- Trial name
- NCT01736059
- Testing
- CD34+ bone marrow stem cells intravitreal
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Venous Ulcer
A Trial to Assess the Safety and Activity of Nexagon® for the Treatment of Venous Leg Ulcers (The NOVEL Study)
Venous leg ulcers are a common, costly and debilitating condition, with few effective treatments. Compression bandaging helps healing, but more than four out of every ten leg ulcers remain unhealed after three months.
- Trial name
- NCT00820196
- Testing
- Nexagon®, Nexagon® vehicle
- Where
- 10 sites in United States, New Zealand
- Volunteers
- 98 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Aortic Stenosis, Left Ventricular Function Systolic Dysfunction
Transcatheter Aortic Valve Implantation Without Predilation
The purpose of this study is to demonstrate that the avoidance of balloon valvuloplasty for predilation of the native aortic valve is associated with a reduction of the composite primary endpoint in TAVI patients with severely…
- Conditions
- Aortic Stenosis, Left Ventricular Function Systolic Dysfunction, High-risk Patients, Transcatheter Aortic Valve Implantation
- Trial name
- SIMPLIFy TAVI (NCT01539746)
- Testing
- TAVI without BAV, TAVI standard procedure
- Where
- 6 sites in Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bonn
Stroke
Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms
The investigators developed a real-time 2-axis mirror robot system as a simple add-on module for conventional mirror therapy using a closed feedback mechanism, which allows for real-time movement of the hemiplegic arm.
- Trial name
- NCT02878746
- Testing
- Robotic mirror therapy, Conventional mirror therapy
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Aortic Valve Stenosis, Intracranial Embolism and Thrombosis
NAUTILUS CE-mark Trial of the FLOWer Cerebral Embolic Protection Device
The purpose of this clinical study is to assess the safety, performance, and treatment effect of the use of the AorticLab FLOWer System, in preventing cerebral thromboembolic complications in patients with indication for a TAVI…
- Trial name
- NAUTILUS (NCT04704258)
- Testing
- TAVI (Transcatheter Aortic Valve Implant), FLOWer Embolic Protection System
- Where
- 8 sites in Belgium, Italy
- Volunteers
- 100 people
- Sponsor
- AorticLab Srl
Hypertension
Sympathetic Activity and Renal Denervation
Primary hypothesis: Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension. Secondary hypotheses: 1.
- Trial name
- ReD (NCT01355055)
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Multiple Myeloma
Study of Selinexor (KPT- 330), Lenalidomide, & Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients
This is an open-label, randomized clinical study with two stages to assess the maximum tolerated dose (MTD), efficacy, and safety of selinexor, lenalidomide, and dexamethasone (SLd) in patients with relapsed/refractory (RR)…
- Trial name
- SLAM (NCT02389543)
- Testing
- Selinexor, Lenalidomide, Dexamethasone
- Sponsor
- Karyopharm Therapeutics Inc
Cerebral Venous Sinus Thrombosis
Dabigatran Versus Apixaban in Cerebral Venous Thrombosis
Along with the current clinical trial, the efficacy and safety of a 150 mg Bid dabigatran administered within 24 hours of randomization after having first-ever cerebral venous thrombosis compared to apixaban 5mg Bid were assessed…
- Trial name
- NCT06551415
- Testing
- Dabigatran Etexilate 150mg, Apixaban 5MG
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kafrelsheikh University
Diastolic Dysfunction, Hypertension
Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients
This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.
- Conditions
- Diastolic Dysfunction, Hypertension, Inflammation
- Trial name
- NCT03177408
- Volunteers
- 100 people
- Sponsor
- Jing Li
Stroke
Real-time Personalized Brain State-dependent TMS After Stroke
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke.
- Trial name
- NCT06533176
- Testing
- Personalized brain state-dependent single-pulse TMS
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Sara Hussain
Stroke, Cardiac Disease
HIIT vs HRV-based Training for Rehabilitation After Stroke
Consequences of stroke are manyfold but all of them are important factors on the long-term outcomes of rehabilitation, becoming an important health problem with requires health strategies with advanced age.
- Conditions
- Stroke, Cardiac Disease, Ischemic Stroke, Ischemic Heart Disease
- Trial name
- NCT05612776
- Testing
- HIIT, HRV
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Almeria
Uncontrolled Hypertension
A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Uncontrolled Hypertension
This is a multicenter, randomized, double-blind, placebo-controlled phase II study designed to explore the efficacy and safety of different doses of SAL0140 in uncontrolled hypertension.
- Trial name
- NCT07654140
- Testing
- SAL0140
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
IVF, Frozen Embryo Transfer (FET)
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
- Conditions
- IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI)
- Trial name
- NCT06471140
- Testing
- magnetic resonance imaging (MRI)
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.