Clinical trials: Cardiovascular Death, open to volunteers
Out of Hospital Cardiac Arrest, Ventricular Fibrillation
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR
- Trial name
- DOUBLE D (NCT07174986)
- Testing
- Double sequential defibirllation, Standard defibrillation
- Where
- 14 sites in Netherlands, Spain and 1 more
- Volunteers
- 916 people
- Sponsor
- Gabriel Riva
Heart Diseases, Death
Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry
The registry for the improvement of postoperative outcomes in cardiac and thoracic surgery aims to prospectively collect data in order to test the association between various preoperative and per-operative variables ; and several…
- Conditions
- Heart Diseases, Death, Postoperative Complications, Cardiac Complication
- Trial name
- RIPOSTE (NCT03209674)
- Testing
- Cardiothoracic surgery
- Where
- France
- Volunteers
- 8,000 people
- Sponsor
- CMC Ambroise Paré
Heart Failure, Dietary Sodium Intake
Effects of Low-Sodium Salt on Death, HF Hospitalization/ Emergency Department Visits and Quality of Life in HF Patients
This study aims to investigate whether using a low-sodium substitute salt can help improve outcomes for patients with heart failure.
- Trial name
- RESCUE-HF (NCT06764225)
- Testing
- low-sodium substitute salt
- Where
- China
- Volunteers
- 1,301 people
- Sponsor
- Heart Health Research Center
Sudden Cardiac Death, Myocardial Infarction
Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction
TWIN-SCD STEMI is a multicentric prospective, non-randomized pilot study designed to establish a multiparametric model for predicting life-threatening ventricular arrhythmias in patients experiencing their first myocardial…
- Trial name
- TWIN-SCD STEMI (NCT07527494)
- Testing
- Programmed ventricular stimulation, Cardiac CT scan
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bordeaux
Heart Failure
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one…
- Trial name
- Prevent-HF (NCT06677060)
- Testing
- Baxdrostat and dapagliflozin
- Where
- 977 sites in United States, Argentina and 33 more
- Volunteers
- 11,300 people
- Sponsor
- AstraZeneca
Sudden Cardiac Arrest
HeartStart HS1 Defibrillator* Event Registry
A Prospective study on the performance and safety of the HeartStart OnSite (Model M5066A) \& HeartStart Home (Model M5068A) Defibrillator device data.
- Trial name
- NCT04840797
- Testing
- HeartStart HS1
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Heartstream US LLC
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Mitral Valve Prolapse Arrhythmic Risk
Mitral valve prolapse (MVP) is common with a 2-3 % prevalence in the general association and generally associated with a favorable prognosis.
- Trial name
- MVP-Risk (NCT07830888)
- Testing
- Risk prediction model
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Mitral Annular Disjunction, Mitral Valve
Loop Recorder Implantation in Patients With Mitral Annular Disjunction
The goal of clinical trial is to prospectively collect data to investigate the prevalence of arrhythmia in young patients diagnosed with mitral annular disjunction who have no indication for implantable cardioverter defibrillator…
- Conditions
- Mitral Annular Disjunction, Mitral Valve, Arrhythmia Ventricular, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- ILR MAD IIT (NCT07436962)
- Testing
- loop recorder implantation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Complex Coronary Artery Disease
Procedural Complications and Long-Term Mortality in Complex Coronary Interventions
The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described.
- Trial name
- NCT07202754
- Where
- Turkey (Türkiye)
- Volunteers
- 20,000 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Ventilation During Resuscitation
Intra Arrest Ventilation in Human Cadavers II
The study investigates the influence of three types of ventilation mode by using Bi-Level positive airway pressure (pinsp 20 mbar, PEEP 5, AF 10/min) with two different types of ventilators ( Medumat vs.
- Trial name
- NCT06885398
- Testing
- treatment
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Muehlenkreiskliniken, MKK
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester
End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5)
Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant.
- Conditions
- End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5), Kidney Transplantation Recipients
- Trial name
- NCT07385651
- Testing
- 10˚C deceased donor kidney storage using Traferox XPort
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Pregnancy, Postpartum
Organ Dysfunction Score for Obstetric Patients
The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse…
- Conditions
- Pregnancy, Postpartum, Organ Dysfunction, Critical Care, Intensive Care
- Trial name
- SOFA-OBS (NCT07068022)
- Testing
- Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)
- Where
- 18 sites in Argentina, Ecuador and 2 more
- Volunteers
- 130 people
- Sponsor
- Daniela Vasquez
Myocardial Infarction (MI), Sudden Cardiac Death Due to Cardiac Arrhythmia
ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Cardiac Death in Moderated LVEF in ischEmic cardiomyopathY
Although advances in treatment and patient management have considerably improved post-infarction prognosis, the risk of sudden cardiac death remains a major concern.
- Trial name
- ODISSEY (NCT07545512)
- Testing
- This study involved an auxillary CE-marked medical device (implantable holter for cardiac rhythm monitoring)
- Where
- 15 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Apical Hypertrophic Cardiomyopathy
Surgical Treatment of the Patients With Restrictive Phenotype of the Hypertrophic Cardiomyopathy Without LVOT Obstruction
Hypertrophic cardiomyopathy - is an inherited disease characterized by pronounced genetic and phenotypic heterogeneity. There are two most common anatomic variants of cardiac hypertrophy: subaortic and submitral phenotypes.
- Trial name
- NCT06977646
- Testing
- Surgical transaortic left ventricular cavity remodeling in patients with apical hypertrophic cardiomyopathy without left ventricular outflow tract obstruction
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Cardiac Arrest (CA), Sudden Death, Cardiac
Automated Cardiac Arrest Detection and Alerting in Daily Life
Surviving a cardiac arrest that happens outside the hospital depends on quickly recognizing the event and immediately starting CPR.
- Trial name
- DETECT-4b (NCT06692374)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Cardiometabolic Diseases
REal-world Data of CARdiometabolic ProtEcTion
This study is a single-center, historical prospective cohort study including patients diagnosed with metabolic cardiovascular disease, including hypertension, diabetes, obesity, dyslipidemia, hyperuricemia.
- Trial name
- RED-CARPET (NCT07038083)
- Where
- China
- Volunteers
- 40,000 people
- Sponsor
- Sun Yat-sen University
Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
The TaRGET study is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 β inhibitor, in genotype…
- Trial name
- TaRGET (NCT06174220)
- Testing
- Tideglusib
- Where
- 17 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital