Heart FailurePhase 3Prevent-HFNCT06677060

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

A Phase 3 study testing Baxdrostat and dapagliflozin in people with Heart Failure, run by AstraZeneca at 977 sites in 35 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

Search all trials

Trial summary

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. Read more about this study

Who is it for?: Ages 40 years and older
Conditions the study is for: Heart Failure
What is being tested?: Baxdrostat and dapagliflozin
Type of treatment: Pill or oral medicine
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 11,300 participants
Where: 977 sitesin 35 countries
Study dates: 14 Mar 2025to 17 Dec 2029
Phase: Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 40 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Participants of any sex and gender must be ≥ 40 years old at the time of signing the informed consent.
Diagnosed with T2DM and requiring treatment
Established CV disease (ischaemic heart disease, cerebrovascular disease, peripheral arterial disease)
History of HTN and an SBP ≥ 130 mmHg at screening and ≥ 120 mmHg at the Randomisation Visit.
At least one additional risk factor for HF:
Age ≥ 70 years

Show all 11Show fewer

UACR > 20 mg/g
eGFR < 60 mL/min/1.73 m2
History of polyvascular disease (at least two of: ischaemic heart disease, cerebrovascular disease, and peripheral arterial disease)
History of atrial fibrillation or atrial flutter
NT-proBNP > 125 ng/L

Who cannot join

Previously confirmed diagnosis and treatment of heart failure
An eGFR < 30 mL/min/1.73 m2 at screening
Known hyperkalaemia, defined as potassium ≥ 5.5 mmol/L within 3 months prior to screening
Type 1 diabetes mellitus or uncontrolled T2DM with HbA1c > 10.5% (> 91 mmol/mol) at screening
Serum sodium < 135 mmol/L at screening, determined as per central laboratory assessment
Stroke, transient ischaemic cerebral attack, valve implantation or valve replacement, carotid surgery, carotid angioplasty, or cardiac surgery, within 3 months prior to randomisation

Show all 13Show fewer

Myocardial infarction within 3 months prior to randomisation, or within 1 month prior to randomisation when there is no further planned revascularisation
Percutaneous coronary intervention within 1 month prior to randomisation
Known severe hepatic impairment, defined as Child-Pugh Class C, based on records that confirm documented medical history
Documented history of adrenal insufficiency
Any dialysis (including for acute kidney injury) within 3 months prior to screening
Any acute kidney injury within 3 months prior to screening
Prohibited concomitant medications

Trial locations and contacts

977 sites in 35 countries. Contact the study team or a site near you to ask about taking part.

AstraZeneca Clinical Study Information Center contact

1-877-240-9479

information.center@astrazeneca.com

Country

City, postcode or hospital

Sites recruiting now only

977 sites in 35 countries

United States218 sites, 189 recruiting

Research Site
Abilene, Texas, 79606
Recruiting
Research Site
Albany, Georgia, 31707
Suspended
Research Site
Albany, New York, 12208
Suspended
Research Site
Albany, New York, 12211
Recruiting
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Albuquerque, New Mexico, 87102
Recruiting
Research Site
Albuquerque, New Mexico, 87108
Recruiting
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Alexandria, Louisiana, 71303
Recruiting
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Anchorage, Alaska, 99508
Withdrawn
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Arlington, Virginia, 22205
Not yet recruiting
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Atlanta, Georgia, 30303
Recruiting
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Aurora, Colorado, 80012
Recruiting
Research Site
Austin, Texas, 78704
Recruiting
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Baltimore, Maryland, 21229
Recruiting
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Beaumont, Texas, 77702
Recruiting
Research Site
Beaumont, Texas, 77706
Not yet recruiting
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Beavercreek, Ohio, 45431
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Beltsville, Maryland, 20705
Recruiting
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Birmingham, Alabama, 35205
Recruiting
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Boca Raton, Florida, 33487
Not yet recruiting
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Bossier City, Louisiana, 71111
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Boston, Massachusetts, 02115
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Research Site
Bridgeport, Connecticut, 06606
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Brooklyn, New York, 11201
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Brooklyn, New York, 11220
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Brownsville, Texas, 78526
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Burke, Virginia, 22015
Recruiting
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Burlington, Vermont, 05401
Withdrawn
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Camp Hill, Pennsylvania, 17011
Recruiting
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Canton, Georgia, 30114
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Canton, Ohio, 44718
Recruiting
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Carson City, Nevada, 89706
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Centreville, Alabama, 35042
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Champaign, Illinois, 61822
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Charlotte, North Carolina, 28287
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Charlottesville, Virginia, 22911
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Chicago, Illinois, 60616
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Chicago, Illinois, 60621
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Chicago, Illinois, 60631
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Cincinnati, Ohio, 45219
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Cincinnati, Ohio, 45220
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Clearfield, Utah, 84015
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Cleveland, Tennessee, 37312
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Columbia, Missouri, 65201
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Columbia, South Carolina, 29209
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Columbus, Georgia, 31904
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Columbus, Ohio, 43215
Recruiting
Research Site
Columbus, Ohio, 43228
Recruiting
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Concord, California, 94520
Not yet recruiting
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Cordele, Georgia, 31015
Recruiting
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Crystal River, Florida, 34429
Recruiting
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Dallas, Texas, 75390-9015
Recruiting
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Daly City, California, 94015
Not yet recruiting
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Dayton, Ohio, 45424
Recruiting
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Dublin, California, 94568
Withdrawn
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Duncanville, Texas, 75137
Recruiting
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Durham, North Carolina, 27701
Recruiting
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Eatontown, New Jersey, 07724
Withdrawn
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El Dorado, Kansas, 67042
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El Paso, Texas, 79905
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El Paso, Texas, 79935
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Englewood, Colorado, 80110
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Fairfax, Virginia, 22033
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Fairhope, Alabama, 36532
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Falls Church, Virginia, 22042
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Fargo, North Dakota, 58104
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Farmington Hills, Michigan, 48336
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Fayetteville, North Carolina, 28304
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Flint, Michigan, 48532
Recruiting
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Fort Lauderdale, Florida, 33316
Withdrawn
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Fort Mill, South Carolina, 29715
Recruiting
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Fort Myers, Florida, 33912
Recruiting
Research Site
Franklinton, Louisiana, 70438
Not yet recruiting
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Gainesville, Florida, 32608
Withdrawn
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Gilbert, Arizona, 85296
Recruiting
Research Site
Glendale, Arizona, 85308
Completed
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Goose Creek, South Carolina, 29445
Not yet recruiting
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Green Bay, Wisconsin, 54303
Withdrawn
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Greenville, North Carolina, 27834
Not yet recruiting
Research Site
Greenville, South Carolina, 29615
Withdrawn
Research Site
Gurnee, Illinois, 60031
Recruiting
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Horsham, Pennsylvania, 19044
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Houston, Texas, 77074
Not yet recruiting
Research Site
Houston, Texas, 77082
Not yet recruiting
Research Site
Houston, Texas, 77084
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Research Site
Houston, Texas, 77087
Not yet recruiting
Research Site
Houston, Texas, 77089
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Huntington Beach, California, 92648
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Huntsville, Alabama, 35801
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Idaho Falls, Idaho, 83404
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Indianapolis, Indiana, 46202
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Inglewood, California, 90301
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Island Lake, Illinois, 60042
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Jacksonville, Florida, 32216
Recruiting
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Jacksonville, North Carolina, 28546
Not yet recruiting
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Kalispell, Montana, 59901
Withdrawn
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Kansas City, Missouri, 64111
Recruiting
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Kansas City, Missouri, 64151
Recruiting
Research Site
Kernersville, North Carolina, 27284
Withdrawn
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Kingwood, West Virginia, 26537
Recruiting
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Kinston, North Carolina, 28504
Recruiting
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La Jolla, California, 92037
Recruiting
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Lakeland, Florida, 33813
Recruiting
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Lakewood, California, 90805
Withdrawn
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Lenexa, Kansas, 66219
Recruiting
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Lewisville, Texas, 75067
Withdrawn
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Lexington, Kentucky, 40509
Recruiting
Research Site
Lincoln, California, 95648
Recruiting
Research Site
Loma Linda, California, 92357
Recruiting
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Los Angeles, California, 90035
Recruiting
Research Site
Los Angeles, California, 90073
Recruiting
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Louisville, Kentucky, 40218
Recruiting
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Lutherville-Timonium, Maryland, 21093
Recruiting
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Manassas, Virginia, 20110
Recruiting
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Mankato, Minnesota, 56001
Recruiting
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Mansfield, Texas, 76063
Withdrawn
Research Site
Massapequa, New York, 11758
Recruiting
Research Site
Maumee, Ohio, 43537
Recruiting
Research Site
McAllen, Texas, 78501
Recruiting
Research Site
McAllen, Texas, 78503
Recruiting
Research Site
Medford, Oregon, 97504
Withdrawn
Research Site
Mesquite, Texas, 75149
Recruiting
Research Site
Mesquite, Texas, 75149
Not yet recruiting
Research Site
Miami, Florida, 33125
Recruiting
Research Site
Miami, Florida, 33135
Completed
Research Site
Miami, Florida, 33173
Recruiting
Research Site
Miami, Florida, 33175
Recruiting
Research Site
Miami, Florida, 33269
Not yet recruiting
Research Site
Miami Lakes, Florida, 33016
Recruiting
Research Site
Midlothian, Virginia, 23112
Recruiting
Research Site
Milwaukee, Wisconsin, 53226
Withdrawn
Research Site
Minneapolis, Minnesota, 55417
Recruiting
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Missoula, Montana, 59804
Recruiting
Research Site
Mobile, Alabama, 36608
Recruiting
Research Site
Monroe, North Carolina, 28112
Recruiting
Research Site
Morganton, North Carolina, 28655
Not yet recruiting
Research Site
Morgantown, West Virginia, 26505
Recruiting
Research Site
Morristown, Tennessee, 37813
Recruiting
Research Site
Mt. Pleasant, South Carolina, 29464
Recruiting
Research Site
Munster, Indiana, 46321
Recruiting
Research Site
Nashville, Tennessee, 37203
Recruiting
Research Site
New Bedford, Massachusetts, 02740
Completed
Research Site
New Bern, North Carolina, 28562
Recruiting
Research Site
New York, New York, 10029
Recruiting
Research Site
Newton, Kansas, 67114
Recruiting
Research Site
Norfolk, Nebraska, 68701
Recruiting
Research Site
Norfolk, Virginia, 23502
Recruiting
Research Site
Norfolk, Virginia, 23504
Recruiting
Research Site
Norman, Oklahoma, 73069
Withdrawn
Research Site
North Charleston, South Carolina, 29405
Recruiting
Research Site
Ocoee, Florida, 34761
Suspended
Research Site
Ogden, Utah, 84405
Recruiting
Research Site
Oklahoma City, Oklahoma, 73111
Recruiting
Research Site
Oklahoma City, Oklahoma, 73120
Recruiting
Research Site
Olla, Louisiana, 71465
Not yet recruiting
Research Site
Omaha, Nebraska, 68134
Recruiting
Research Site
Orlando, Florida, 32822
Recruiting
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Owensboro, Kentucky, 42301
Recruiting
Research Site
Paducah, Kentucky, 42001
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Palmetto Bay, Florida, 33157
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Paris, Texas, 75462
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Park Ridge, Illinois, 60068
Recruiting
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Pearland, Texas, 77584
Suspended
Research Site
Pennington, New Jersey, 08534
Recruiting
Research Site
Philadelphia, Pennsylvania, 19114
Recruiting
Research Site
Portsmouth, New Hampshire, 03801
Withdrawn
Research Site
Potomac, Maryland, 20854
Recruiting
Research Site
Puyallup, Washington, 98372
Not yet recruiting
Research Site
Queens Village, New York, 11428
Recruiting
Research Site
Raleigh, North Carolina, 27607
Recruiting
Research Site
Redmond, Washington, 98052
Recruiting
Research Site
Renton, Washington, 98057
Recruiting
Research Site
Richmond, Indiana, 47374
Recruiting
Research Site
Richmond, Virginia, 23249
Withdrawn
Research Site
Riverview, Florida, 33578
Not yet recruiting
Research Site
Rocky Mount, North Carolina, 27804
Recruiting
Research Site
Roslindale, Massachusetts, 02131
Recruiting
Research Site
Sacramento, California, 95841
Recruiting
Research Site
Saint Augustine, Florida, 32086
Recruiting
Research Site
Salem, Virginia, 24153
Recruiting
Research Site
San Antonio, Texas, 78231
Recruiting
Research Site
San Antonio, Texas, 78257
Recruiting
Research Site
San Diego, California, 92120
Recruiting
Research Site
San Dimas, California, 91773
Recruiting
Research Site
San Francisco, California, 94115
Recruiting
Research Site
San Francisco, California, 94121
Withdrawn
Research Site
Santa Maria, California, 93454
Recruiting
Research Site
Scottdale, Pennsylvania, 15683
Recruiting
Research Site
Sheffield, Alabama, 35660
Recruiting
Research Site
Sherman Oaks, California, 91403
Suspended
Research Site
Shreveport, Louisiana, 71101
Recruiting
Research Site
Smithfield, Pennsylvania, 15478
Recruiting
Research Site
Somerset, New Jersey, 08873
Recruiting
Research Site
South Bend, Indiana, 46617
Recruiting
Research Site
Spartanburg, South Carolina, 29301
Recruiting
Research Site
St Louis, Missouri, 63136
Recruiting
Research Site
Stamford, Connecticut, 06905
Recruiting
Research Site
Stephenville, Texas, 76401
Recruiting
Research Site
Sugar Land, Texas, 77479
Recruiting
Research Site
Suwanee, Georgia, 30024
Recruiting
Research Site
Tempe, Arizona, 85283
Recruiting
Research Site
Tempe, Arizona, 85284
Not yet recruiting
Research Site
Thousand Oaks, California, 91360
Recruiting
Research Site
Toledo, Ohio, 43606
Recruiting
Research Site
Tomball, Texas, 77375
Recruiting
Research Site
Troy, Michigan, 48098
Recruiting
Research Site
Tucker, Georgia, 30084
Recruiting
Research Site
Tucson, Arizona, 85712
Recruiting
Research Site
Vestavia Hills, Alabama, 35216
Recruiting
Research Site
Victoria, Texas, 77901
Not yet recruiting
Research Site
Waterbury, Connecticut, 06708
Recruiting
Research Site
Weslaco, Texas, 78596
Recruiting
Research Site
West Chester, Pennsylvania, 19380
Suspended
Research Site
Wichita, Kansas, 67214
Not yet recruiting
Research Site
Wichita, Kansas, 67218
Withdrawn
Research Site
Wilmington, North Carolina, 28401
Recruiting
Research Site
Woodstock, Georgia, 30189
Recruiting
Research Site
Woodway, Texas, 76712
Recruiting
Research Site
Ypsilanti, Michigan, 48197
Recruiting

Other trials in United States

Germany68 sites, 52 recruiting

Research Site
Aachen, 52074
Recruiting
Research Site
Amberg, 92224
Recruiting
Research Site
Bad Homburg, 61348
Withdrawn
Research Site
Bad Oeynhausen, 32545
Recruiting
Research Site
Bamberg, 96049
Recruiting
Research Site
Bechhofen, 66894
Recruiting
Research Site
Berlin, 10367
Withdrawn
Research Site
Berlin, 10789
Recruiting
Research Site
Berlin, 12203
Recruiting
Research Site
Berlin, 13187
Recruiting
Research Site
Berlin, 13353
Recruiting
Research Site
Berlin, 13405
Not yet recruiting
Research Site
Berlin, 13597
Recruiting
Research Site
Bochum, 44789
Recruiting
Research Site
Bochum, 44869
Recruiting
Research Site
Brandenburg an der Havel, 14770
Recruiting
Research Site
Brandenburg an der Havel, 14776
Recruiting
Research Site
Bremen, 28277
Recruiting
Research Site
Cologne, 51065
Recruiting
Research Site
Cologne, 51069
Withdrawn
Research Site
Deggingen, 73326
Recruiting
Research Site
Dresden, 01069
Withdrawn
Research Site
Dresden, 01277
Recruiting
Research Site
Elsterwerda, 04910
Recruiting
Research Site
Essen, 45136
Recruiting
Research Site
Essen, 45355
Recruiting
Research Site
Essen, 45355
Withdrawn
Research Site
Frankfurt, 60596
Recruiting
Research Site
Freiburg im Breisgau, 79106
Recruiting
Research Site
Friedrichsthal, 66299
Withdrawn
Research Site
Fulda, 36037
Recruiting
Research Site
Gelnhausen, 63571
Recruiting
Research Site
Görlitz, 02828
Recruiting
Research Site
Hamburg, 21109
Recruiting
Research Site
Hamburg, 22041
Recruiting
Research Site
Hamburg, 22459
Recruiting
Research Site
Hamburg, 22607
Recruiting
Research Site
Haßloch, 67454
Withdrawn
Research Site
Heidelberg, 69120
Recruiting
Research Site
Homburg, 66424
Recruiting
Research Site
Kaiserslautern, 67655
Recruiting
Research Site
Kassel, 34121
Recruiting
Research Site
Langen, 63225
Recruiting
Research Site
Leipzig, 04179
Recruiting
Research Site
Leipzig, 04249
Recruiting
Research Site
Leipzig, 04347
Recruiting
Research Site
Ludwigshafen, 67059
Withdrawn
Research Site
Ludwigshafen, 67063
Recruiting
Research Site
Mannheim, 68165
Withdrawn
Research Site
Markkleeberg, 04416
Terminated
Research Site
Munich, 80809
Withdrawn
Research Site
Münster, 48153
Withdrawn
Research Site
Naunhof, 04683
Recruiting
Research Site
Neuruppin, 16816
Recruiting
Research Site
Nittendorf, 93152
Recruiting
Research Site
Obertshausen, 63179
Recruiting
Research Site
Oldenburg, 23758
Recruiting
Research Site
Osnabrück, 49080
Recruiting
Research Site
Papenburg, 26871
Recruiting
Research Site
Pirna, 01796
Recruiting
Research Site
Potsdam, 14473
Withdrawn
Research Site
Ratingen, 40882
Recruiting
Research Site
Reinfeld (Holstein), 23858
Recruiting
Research Site
Völklingen, 66333
Withdrawn
Research Site
Wallerfing, 94574
Recruiting
Research Site
Wangen, 88239
Withdrawn
Research Site
Weinheim, 69469
Recruiting
Research Site
Zwenkau, 04442
Withdrawn

Other trials in Germany

China57 sites, 55 recruiting

Research Site
Baotou, 14010
Recruiting
Research Site
Beijing, 100029
Withdrawn
Research Site
Beijing, 100029
Recruiting
Research Site
Beijing, 100050
Recruiting
Research Site
Changchun, 130021
Recruiting
Research Site
Changchun, 130033
Recruiting
Research Site
Changde, 415000
Recruiting
Research Site
Changsha, 410011
Recruiting
Research Site
Changsha, 410015
Recruiting
Research Site
Changzhou, 272100
Recruiting
Research Site
Chengdu, 610000
Recruiting
Research Site
Chengdu, 610041
Recruiting
Research Site
Chifeng, 024000
Recruiting
Research Site
Chongqing, 400014
Recruiting
Research Site
Chongqing, 400042
Recruiting
Research Site
Guangzhou, 510100
Recruiting
Research Site
Guangzhou, 511486
Recruiting
Research Site
Harbin, 150000
Recruiting
Research Site
Hefei, 230001
Withdrawn
Research Site
Hengyang, 421001
Recruiting
Research Site
Heze, 274099
Recruiting
Research Site
Huangshi, 435000
Recruiting
Research Site
Huizhou, 516002
Recruiting
Research Site
Jinan, 250001
Recruiting
Research Site
Jining, 272006
Recruiting
Research Site
Kaifeng, 475000
Recruiting
Research Site
Liaocheng, 252000
Recruiting
Research Site
Linyi, 276003
Recruiting
Research Site
Lishui, 323000
Recruiting
Research Site
Luoyang, 471000
Recruiting
Research Site
Luoyang, 471001
Recruiting
Research Site
Meihekou, 135022
Recruiting
Research Site
Nanchang, 330009
Recruiting
Research Site
Nanjing, 210008
Recruiting
Research Site
Nantong, 226001
Recruiting
Research Site
Nanyang, 473000
Recruiting
Research Site
Panjin, 124009
Recruiting
Research Site
Pingxiang, 337055
Recruiting
Research Site
Sanya, 572000
Recruiting
Research Site
Shanghai, 200240
Recruiting
Research Site
Shanghai, 201114
Recruiting
Research Site
Shenyang, 110016
Recruiting
Research Site
Siping, 136000
Recruiting
Research Site
Suzhou, 215004
Recruiting
Research Site
Taiyuan, 030024
Recruiting
Research Site
Taizhou, 317000
Recruiting
Research Site
Tianjin, 300000
Recruiting
Research Site
Wenzhou, 325000
Recruiting
Research Site
Wuhan, 430010
Recruiting
Research Site
Wuhan, 430060
Recruiting
Research Site
Xi'an, 710061
Recruiting
Research Site
Xi'an, 710068
Recruiting
Research Site
Xianyang, 750004
Recruiting
Research Site
Xuzhou, 221009
Recruiting
Research Site
Yinchuan, 750004
Recruiting
Research Site
Zhumadian, 463000
Recruiting
Research Site
Zigong, 643000
Recruiting

Other trials in China

Poland52 sites, 43 recruiting

Research Site
Biała Podlaska, 21-500
Withdrawn
Research Site
Bialystok, 15-481
Recruiting
Research Site
Bydgoszcz, 85-095
Withdrawn
Research Site
Chojnice, 89-600
Withdrawn
Research Site
Chojnice, 89-600
Recruiting
Research Site
Chrzanów, 32-500
Recruiting
Research Site
Częstochowa, 42-202
Recruiting
Research Site
Gdansk, 80-214
Recruiting
Research Site
Gdansk, 80-286
Withdrawn
Research Site
Gdynia, 81-157
Recruiting
Research Site
Gdynia, 81-537
Recruiting
Research Site
Jasło, 38-200
Recruiting
Research Site
Katowice, 40-040
Recruiting
Research Site
Katowice, 40-081
Recruiting
Research Site
Katowice, 40-156
Recruiting
Research Site
Katowice, 40-600
Recruiting
Research Site
Katowice, 40-748
Recruiting
Research Site
Katowice, 40-752
Withdrawn
Research Site
Krakow, 31-121
Recruiting
Research Site
Krakow, 31-322
Recruiting
Research Site
Lodz, 90-302
Recruiting
Research Site
Lodz, 90-549
Withdrawn
Research Site
Lublin, 20-068
Recruiting
Research Site
Lublin, 20-518
Withdrawn
Research Site
Lublin, 20-718
Recruiting
Research Site
Lublin, 20-857
Recruiting
Research Site
Myszków, 42-300
Recruiting
Research Site
Olsztyn, 10-165
Recruiting
Research Site
Ostrów Mazowiecka, 07-300
Recruiting
Research Site
Piekary Śląskie, 41-940
Recruiting
Research Site
Płock, 09-407
Recruiting
Research Site
Poznan, 60-111
Recruiting
Research Site
Poznan, 60-309
Recruiting
Research Site
Poznan, 60-702
Recruiting
Research Site
Poznan, 61-848
Recruiting
Research Site
Przemyśl, 37-700
Recruiting
Research Site
Radzionków, 41-922
Recruiting
Research Site
Rzeszów, 35-205
Recruiting
Research Site
Skórzewo, 60-185
Recruiting
Research Site
Szczecin, 71-434
Withdrawn
Research Site
Szczecin, 71-526
Recruiting
Research Site
Tarnów, 33-100
Recruiting
Research Site
Torun, 87-100
Recruiting
Research Site
Warsaw, 00-124
Recruiting
Research Site
Warsaw, 00-872
Recruiting
Research Site
Warsaw, 02-507
Recruiting
Research Site
Warsaw, 02-758
Recruiting
Research Site
Warsaw, 02-798
Recruiting
Research Site
Warsaw, 04-501
Recruiting
Research Site
Warsaw, 04-628
Recruiting
Research Site
Wroclaw, 50-981
Recruiting
Research Site
Zabrze, 41-800
Withdrawn

Other trials in Poland

Japan45 sites, 42 recruiting

Research Site
Amagasaki-shi, 660-8550
Recruiting
Research Site
Asahikawa-shi, 070-8610
Recruiting
Research Site
Azumino-shi, 399-8292
Recruiting
Research Site
Chūōku, 103-0002
Recruiting
Research Site
Fukui-shi, 910-8526
Recruiting
Research Site
Hakusan-shi, 924-8588
Recruiting
Research Site
Himeji, 670-8560
Recruiting
Research Site
Itabashi-ku, 173-0015
Recruiting
Research Site
Izumo-shi, 693-8501
Recruiting
Research Site
Kakegawa-shi, 436-8555
Recruiting
Research Site
Kamakura-shi, 247-8533
Recruiting
Research Site
Kanazawa, 920-8650
Recruiting
Research Site
Kawaguchi-shi, 332-8558
Recruiting
Research Site
Kishiwada-shi, 596-0042
Recruiting
Research Site
Kita-ku, 114-0001
Recruiting
Research Site
Kyoto, 601-1495
Completed
Research Site
Kyoto, 605-0981
Recruiting
Research Site
Kyoto, 606-8507
Recruiting
Research Site
Matsudo-shi, 271-0077
Recruiting
Research Site
Meguro-ku, 153-0051
Recruiting
Research Site
Mito, 311-4198
Recruiting
Research Site
Miyazaki, 880-0834
Recruiting
Research Site
Nagano, 399-8695
Recruiting
Research Site
Ogaki-shi, 503-8502
Recruiting
Research Site
Ōita, 870-8511
Recruiting
Research Site
Ōmihachiman, 523-0082
Recruiting
Research Site
Osaka, 530-8480
Recruiting
Research Site
Osaka, 534-0024
Completed
Research Site
Osaka, 553-0003
Recruiting
Research Site
Osaka, 558-8558
Recruiting
Research Site
Saitama-shi, 338-0837
Recruiting
Research Site
Sendai, 980-8574
Recruiting
Research Site
Sendai, 983-0039
Recruiting
Research Site
Shizuoka, 424-0911
Recruiting
Research Site
Suita-shi, 564-8565
Recruiting
Research Site
tabashi City, 173-8606
Withdrawn
Research Site
Takamatsu, 760-0017
Recruiting
Research Site
Takatsuki-shi, 569-1192
Recruiting
Research Site
Toyota-Shi, 471-8513
Recruiting
Research Site
Tsuchiura-shi, 300-0028
Recruiting
Research Site
Ueda-shi, 386-8610
Recruiting
Research Site
Uwajima-shi, 798-8510
Recruiting
Research Site
Yanagawa-shi, 832-0077
Recruiting
Research Site
Yokkaichi-shi, 510-8561
Recruiting
Research Site
Yokohama, 230-8765
Recruiting

Other trials in Japan

Canada37 sites, 34 recruiting

Research Site
Abbotsford British Columbia, British Columbia, V2S 0C2
Recruiting
Research Site
Calgary, Alberta, T2H 2G4
Recruiting
Research Site
Calgary, Alberta, T2V 4J2
Recruiting
Research Site
Cambridge, Ontario, N1R 6V6
Withdrawn
Research Site
Guelph, Ontario, N1H 1B1
Recruiting
Research Site
Halifax, Nova Scotia, B3H 1V7
Recruiting
Research Site
Hamilton, Ontario, L8J 0B6
Recruiting
Research Site
Hamilton, Ontario, L8L 5G4
Recruiting
Research Site
Laval, Quebec, H7T 2P5
Recruiting
Research Site
Lévis, Quebec, G6V 9H4
Recruiting
Research Site
Markham, Ontario, L3S 0A2
Recruiting
Research Site
Mirabel, Quebec, J7J 2K8
Recruiting
Research Site
Moncton, New Brunswick, E1C 2Z3
Recruiting
Research Site
Montreal, Quebec, H1T 1C8
Recruiting
Research Site
Montreal, Quebec, H4A 3T2
Recruiting
Research Site
Newmarket, Ontario, L3Y 2P6
Recruiting
Research Site
North York, Ontario, M6B 3H7
Recruiting
Research Site
North York, Ontario, M9N 1W4
Withdrawn
Research Site
Oakville, Ontario, L6K 3W7
Recruiting
Research Site
Ottawa, Ontario, K2J 0V2
Recruiting
Research Site
Québec, Quebec, G1G 5X1
Recruiting
Research Site
Québec, Quebec, G1V 4G5
Recruiting
Research Site
Regina, Saskatchewan, S4P 0W5
Recruiting
Research Site
Saint John, New Brunswick, E2L 4L2
Recruiting
Research Site
Saint-Charles-Borromée, Quebec, J6E 6J2
Recruiting
Research Site
Sarnia, Ontario, N7T 4X3
Recruiting
Research Site
Scarborough Village, Ontario, M1B 4Z8
Recruiting
Research Site
Sherbrooke, Quebec, J1H 5N4
Recruiting
Research Site
Sherwood Park, Alberta, T8H 0N2
Recruiting
Research Site
St. John's, Newfoundland and Labrador, A1B 3V6
Recruiting
Research Site
Sydney, Nova Scotia, B1P 1P3
Recruiting
Research Site
Terrebonne, Quebec, J6X 4P7
Recruiting
Research Site
Toronto, Ontario, M4G 3E8
Recruiting
Research Site
Toronto, Ontario, M5B 1W8
Withdrawn
Research Site
Toronto, Ontario, M6C 1C2
Recruiting
Research Site
Toronto, Ontario, M6G 1M2
Recruiting
Research Site
Trois-Rivières, Quebec, G9A 4P3
Recruiting

Other trials in Canada

France31 sites, 28 recruiting

Research Site
Amiens, 80054
Recruiting
Research Site
Angers, 49933
Recruiting
Research Site
Aurillac, 15002
Recruiting
Research Site
Besançon, 25030
Recruiting
Research Site
Bobigny, 93000
Recruiting
Research Site
Bois-Guillaume, 76230
Recruiting
Research Site
Brest, 29200
Recruiting
Research Site
Caen, 14033
Recruiting
Research Site
Cholet, 49300
Recruiting
Research Site
Clermont-Ferrand, 63000
Withdrawn
Research Site
Colombes, 92700
Recruiting
Research Site
Corbeil-Essonnes, 91106
Recruiting
Research Site
Dijon, 2100
Recruiting
Research Site
La Roche-sur-Yon, 85925
Recruiting
Research Site
La Rochelle, 17000
Recruiting
Research Site
Le Coudray, 28630
Recruiting
Research Site
Le Creusot, 71206
Withdrawn
Research Site
Lyon, 69007
Recruiting
Research Site
Marseille, 13385
Recruiting
Research Site
Montpellier, 34295
Withdrawn
Research Site
Nantes, 44093
Recruiting
Research Site
Narbonne, 11108
Recruiting
Research Site
Nîmes, 30029
Recruiting
Research Site
Paris, 75010
Recruiting
Research Site
Paris, 75014
Recruiting
Research Site
Paris, 75018
Recruiting
Research Site
Paris, 75908
Recruiting
Research Site
Pierre-Bénite, 69495
Recruiting
Research Site
Toulouse, 31059
Recruiting
Research Site
Vandœuvre-lès-Nancy, 54511
Recruiting
Research Site
Villeurbanne, 69100
Recruiting

Other trials in France

Italy28 sites, 27 recruiting

Research Site
Alessandria, 15100
Recruiting
Research Site
Bari, 70124
Recruiting
Research Site
Bergamo, 24127
Recruiting
Research Site
Brescia, 25123
Recruiting
Research Site
Chiavari, 16034
Recruiting
Research Site
Cona, 44124
Recruiting
Research Site
Foggia, 71100
Recruiting
Research Site
Milan, 20122
Recruiting
Research Site
Milan, 20132
Recruiting
Research Site
Milan, 20138
Recruiting
Research Site
Milan, 20154
Recruiting
Research Site
Milan, 20162
Recruiting
Research Site
Mondovì, 12084
Withdrawn
Research Site
Monza, 20900
Recruiting
Research Site
Naples, 80131
Recruiting
Research Site
Novara, 28100
Recruiting
Research Site
Orbassano, 10043
Recruiting
Research Site
Palermo, 90127
Recruiting
Research Site
Pavia, 27100
Recruiting
Research Site
Potenza, 85100
Recruiting
Research Site
Roma, 00128
Recruiting
Research Site
Roma, 00133
Recruiting
Research Site
Roma, 161
Recruiting
Research Site
Rome, 00168
Recruiting
Research Site
Rozzano, 20089
Recruiting
Research Site
Siena, 53100
Recruiting
Research Site
Torino, 10126
Recruiting
Research Site
Udine, 33100
Recruiting

Other trials in Italy

India27 sites, 21 recruiting

Research Site
Ahmedabad, 380054
Withdrawn
Research Site
Ajmer, 305001
Withdrawn
Research Site
Bangalore, 560069
Withdrawn
Research Site
Belagavi, 590010
Recruiting
Research Site
Dehradun, 248001
Recruiting
Research Site
Delhi, 110060
Not yet recruiting
Research Site
Delhi, 110062
Recruiting
Research Site
Gūrgaon, 122001
Recruiting
Research Site
Hyderabad, 500 034
Recruiting
Research Site
Hyderabad, 500018
Withdrawn
Research Site
Hyderabad, 500035
Recruiting
Research Site
Hyderabad, 500082
Recruiting
Research Site
Kanpur, 208001
Recruiting
Research Site
Karamsad, 388345
Withdrawn
Research Site
Kolkata, 700014
Recruiting
Research Site
Kolkata, 700020
Recruiting
Research Site
Lucknow, 226010
Withdrawn
Research Site
Mumbai, 400012
Not yet recruiting
Research Site
Nagpur, 440010
Not yet recruiting
Research Site
Nagpur, 441108
Recruiting
Research Site
New Delhi, 100049
Recruiting
Research Site
New Delhi, 110002
Recruiting
Research Site
New Delhi, 110017
Recruiting
Research Site
Secunderabad, 500003
Recruiting
Research Site
Surat, 395001
Recruiting
Research Site
Surat, 396007
Recruiting
Research Site
Vijayawada, 520 008
Recruiting

Other trials in India

Hungary25 sites, 20 recruiting

Research Site
Balatonfüred, 8230
Recruiting
Research Site
Balatonfüred, 8230
Withdrawn
Research Site
Békéscsaba, 5600
Recruiting
Research Site
Budapest, 1033
Recruiting
Research Site
Budapest, 1036
Recruiting
Research Site
Budapest, 1083
Recruiting
Research Site
Budapest, 1102
Recruiting
Research Site
Budapest, 1106
Recruiting
Research Site
Budapest, 1122
Recruiting
Research Site
Budapest, 1134
Not yet recruiting
Research Site
Budapest, 1148
Recruiting
Research Site
Debrecen, 4032
Recruiting
Research Site
Gyöngyös, 3200
Withdrawn
Research Site
Kalocsa, 6300
Recruiting
Research Site
Nyíregyháza, 4400
Withdrawn
Research Site
Nyíregyháza, 4400
Recruiting
Research Site
Nyíregyháza, 4405
Withdrawn
Research Site
Nyíregyháza-Sóstóhegy, 4481
Recruiting
Research Site
Orosháza, 5900
Withdrawn
Research Site
Pécs, 7623
Recruiting
Research Site
Pécs, 7635
Recruiting
Research Site
Szeged, 6724
Recruiting
Research Site
Székesfehérvár, 8000
Recruiting
Research Site
Szigetvár, 7900
Recruiting
Research Site
Szolnok, 5000
Recruiting

Other trials in Hungary

Brazil23 sites, 21 recruiting

Research Site
Belém, 66073-005
Recruiting
Research Site
Blumenau, 89010-022
Recruiting
Research Site
Bragança Paulista, 12916-542
Recruiting
Research Site
Brasília, 71625-009
Recruiting
Research Site
Campina Grande do Sul, 83.430-000
Recruiting
Research Site
Campinas, 13060-080
Recruiting
Research Site
Campinas, 13060-803
Recruiting
Research Site
Curitiba, 80030-480
Recruiting
Research Site
Curitiba, 80810-050
Recruiting
Research Site
Juiz de Fora, 36033-318
Withdrawn
Research Site
Natal, 59020-500
Recruiting
Research Site
Porto Alegre, 90160-093
Recruiting
Research Site
Porto Alegre, 90610-001
Recruiting
Research Site
Porto Alegre, 90630-165
Recruiting
Research Site
Porto Alegre, 91350-200
Recruiting
Research Site
Rio de Janeiro, 20241-180
Recruiting
Research Site
São José do Rio Preto, 15090-000
Recruiting
Research Site
São José dos Campos, 12230-001
Recruiting
Research Site
São Paulo, 01228-000
Withdrawn
Research Site
São Paulo, 01236-030
Recruiting
Research Site
São Paulo, 04012-180
Recruiting
Research Site
São Paulo, 05403-000
Recruiting
Research Site
Tatuí, 18270-170
Recruiting

Other trials in Brazil

South Africa21 sites, 19 recruiting

Research Site
Bellville, 7530
Recruiting
Research Site
Benoni, 1501
Recruiting
Research Site
Brackenfell, 7560
Recruiting
Research Site
Cape Town, 1730
Withdrawn
Research Site
Cape Town, 7500
Recruiting
Research Site
Centurion, 0157
Recruiting
Research Site
Claremont, 7708
Recruiting
Research Site
Diepkloof, Soweto, 2013
Recruiting
Research Site
Durban, 4001
Recruiting
Research Site
Durban, 4052
Recruiting
Research Site
East London, 5219
Recruiting
Research Site
eMkhomazi, 4170
Recruiting
Research Site
Johannesburg, 1827
Recruiting
Research Site
Lenasia, 1827
Recruiting
Research Site
Midrand, 1685
Recruiting
Research Site
Paarl, 7646
Recruiting
Research Site
Pretoria, 0184
Withdrawn
Research Site
Pretoria, 0186
Recruiting
Research Site
Somerset West, 7130
Recruiting
Research Site
Wentworth, 4032
Recruiting
Research Site
Worcester, 6850
Recruiting

Other trials in South Africa

Czechia20 sites, 19 recruiting

Research Site
Benešov, 256 01
Recruiting
Research Site
Brandýs nad Labem, 250 01
Recruiting
Research Site
Brno, 603 00
Recruiting
Research Site
Brno, 639 00
Recruiting
Research Site
Chlumec nad Cidlinou, 503 51
Recruiting
Research Site
Hodonín, 695 01
Recruiting
Research Site
Humpolec, 396 01
Recruiting
Research Site
Jaroměř, 551 01
Recruiting
Research Site
Jílové u Prahy, 254 01
Recruiting
Research Site
Krnov, 794 01
Recruiting
Research Site
Olomouc, 772 00
Completed
Research Site
Ostrava, 702 00
Recruiting
Research Site
Pilsen, 301 00
Recruiting
Research Site
Police nad Metují, 549 54
Recruiting
Research Site
Prague, 101 00
Recruiting
Research Site
Prague, 104 00
Recruiting
Research Site
Prague, 12808
Recruiting
Research Site
Prague, 149 00
Recruiting
Research Site
Prague, 150 00
Recruiting
Research Site
Prague, 190 14
Recruiting

Other trials in Czechia

Peru19 sites, 15 recruiting

Research Site
Bellavista, CALLAO 2
Recruiting
Research Site
Callao, Bellavista
Recruiting
Research Site
Chorrillos, Lima 9
Recruiting
Research Site
Cusco, CUSCO 01
Not yet recruiting
Research Site
Lima, 14
Recruiting
Research Site
Lima, 15036
Recruiting
Research Site
Lima, 15038
Not yet recruiting
Research Site
Lima, 15046
Recruiting
Research Site
Lima, 15072
Withdrawn
Research Site
Lima, 15074
Withdrawn
Research Site
Lima, 15088
Recruiting
Research Site
Lima, 15102
Not yet recruiting
Research Site
Lima, 15131
Withdrawn
Research Site
Lima, L18
Withdrawn
Research Site
Lima, L41
Not yet recruiting
Research Site
Lima, LIMA 01
Recruiting
Research Site
Lima, LIMA 11
Not yet recruiting
Research Site
Lima, LIMA 41
Recruiting
Research Site
Piura, 20001
Recruiting

Other trials in Peru

Taiwan18 sites, 18 recruiting

Research Site
Changhua, 500
Recruiting
Research Site
Hsinchu, 300
Recruiting
Research Site
Hualien City, 970473
Recruiting
Research Site
Kaohsiung City, 80756
Recruiting
Research Site
New Taipei City, 231
Recruiting
Research Site
Taichung, 40201
Recruiting
Research Site
Taichung, 404
Recruiting
Research Site
Taichung, 40705
Recruiting
Research Site
Taichung, 433004
Recruiting
Research Site
Tainan, 710
Recruiting
Research Site
Taipei, 10002
Recruiting
Research Site
Taipei, 10449
Recruiting
Research Site
Taipei, 110
Recruiting
Research Site
Taipei, 11101
Recruiting
Research Site
Taipei, 11217
Recruiting
Research Site
Taipei, 11490
Recruiting
Research Site
Taipei, 116
Recruiting
Research Site
Taoyuan, 333
Recruiting

Other trials in Taiwan

Argentina17 sites, 17 recruiting

Research Site
Buenos Aires, C1120AAC
Recruiting
Research Site
Buenos Aires, C1425AGC
Recruiting
Research Site
Caba, C1128AAF
Recruiting
Research Site
CABA, C1056ABH
Recruiting
Research Site
CABA, C1119ACN
Recruiting
Research Site
Ciudad de Buenos Aires, C1428DCO
Recruiting
Research Site
Córdoba, 5000
Not yet recruiting
Research Site
Córdoba, X5003DCP
Recruiting
Research Site
La Plata, B1904
Not yet recruiting
Research Site
Mar del Plata, B7600FZN
Not yet recruiting
Research Site
Mar del Plata, B7600GNY
Recruiting
Research Site
Rosario, 2000
Recruiting
Research Site
Rosario, S2000PBJ
Recruiting
Research Site
San Nicolás, B2900DMH
Recruiting
Research Site
San Nicolás de los Arroyos, B2900DPA
Not yet recruiting
Research Site
San Vicente, 5006
Recruiting
Research Site
Santa Fe, S3000FWO
Recruiting

Other trials in Argentina

Bulgaria17 sites, 15 recruiting

Research Site
Haskovo, 6300
Recruiting
Research Site
Panagyurishte, 4500
Recruiting
Research Site
Petrich, 2850
Withdrawn
Research Site
Pleven, 5800
Recruiting
Research Site
Pleven, 5804
Withdrawn
Research Site
Plovdiv, 4003
Recruiting
Research Site
Rousse, 7000
Recruiting
Research Site
Shumen, 9700
Recruiting
Research Site
Sofia, 1000
Recruiting
Research Site
Sofia, 1309
Recruiting
Research Site
Sofia, 1404
Recruiting
Research Site
Sofia, 1431
Recruiting
Research Site
Sofia, 1527
Recruiting
Research Site
Sofia, 1618
Recruiting
Research Site
Sofia, 1680
Recruiting
Research Site
Stara Zagora, 6003
Recruiting
Research Site
Varna, 9000
Recruiting

Other trials in Bulgaria

Mexico17 sites, 15 recruiting

Research Site
Acapulco, 39670
Withdrawn
Research Site
Aguascalientes, 20230
Recruiting
Research Site
Cuauhtémoc, 6720
Recruiting
Research Site
Cuernavaca, 62448
Recruiting
Research Site
Culiacán, 80200
Not yet recruiting
Research Site
Culiacán, 80230
Recruiting
Research Site
Durango, 34000
Recruiting
Research Site
Guadalajara, 44670
Recruiting
Research Site
Guadalajara, 44670
Withdrawn
Research Site
Mexico City, 10700
Recruiting
Research Site
Monterrey, 64060
Recruiting
Research Site
Querétaro City, 76000
Recruiting
Research Site
San Juan del Río, 76800
Recruiting
Research Site
Veracruz, 91910
Not yet recruiting
Research Site
Xalapa, 91020
Not yet recruiting
Research Site
Xalapa, 91193
Recruiting
Research Site
Zapopan, 45138
Recruiting

Other trials in Mexico

Netherlands17 sites, 17 recruiting

Research Site
's-Hertogenbosch, 5223 LA
Recruiting
Research Site
Almelo, 7609 PP
Recruiting
Research Site
Amsterdam, 1081 GM
Recruiting
Research Site
Amsterdam, 1105 AZ
Recruiting
Research Site
Born, 6121 XK
Recruiting
Research Site
Deventer, 7416 SE
Recruiting
Research Site
Ede, 6716 RP
Recruiting
Research Site
Enschede, 7512 KZ
Recruiting
Research Site
Haarlem, 2035 RC
Recruiting
Research Site
Harderwijk, 3844
Recruiting
Research Site
Hoogeveen, 7909 AA
Recruiting
Research Site
Nijmegen, 6525 GA
Recruiting
Research Site
Roosendaal, 4708 AE
Recruiting
Research Site
Rotterdam, 3015GD
Recruiting
Research Site
Rotterdam, 3045 PM
Recruiting
Research Site
Venlo, 5912 BL
Recruiting
Research Site
Zwolle, 8025AZ
Recruiting

Other trials in Netherlands

Slovakia17 sites, 15 recruiting

Research Site
Bratislava, 831 03
Recruiting
Research Site
Bratislava, 83101
Recruiting
Research Site
Bratislava, 83106
Recruiting
Research Site
Brezno, 977 01
Recruiting
Research Site
Handlová, 972 51
Recruiting
Research Site
Košice, 04001
Recruiting
Research Site
Košice, 04022
Recruiting
Research Site
Ľubochňa, 03491
Recruiting
Research Site
Lučenec, 984 01
Recruiting
Research Site
Malacky, 901 22
Recruiting
Research Site
Námestovo, 029 01
Recruiting
Research Site
Prešov, 080 01
Recruiting
Research Site
Prievidza, 97101
Recruiting
Research Site
Rimavská Sobota, 979 01
Recruiting
Research Site
Rožňava, 048 01
Withdrawn
Research Site
Sabinov, 08301
Withdrawn
Research Site
Svidník, 08901
Recruiting

Other trials in Slovakia

United Kingdom17 sites, 14 recruiting

Research Site
Aberdeen, AB25 2ZN
Recruiting
Research Site
Chesterfield, S40 4AA
Recruiting
Research Site
Dundee, DD1 9SY
Recruiting
Research Site
Gatley, SK8 4NQ
Withdrawn
Research Site
Glasgow, G31 2ER
Recruiting
Research Site
Glasgow, G51 4TF
Recruiting
Research Site
London, E11BB
Recruiting
Research Site
Norwich, NR128DU
Recruiting
Research Site
Penzance, TR18 3DX
Recruiting
Research Site
Redruth, TR16 4ET
Withdrawn
Research Site
Sandbach, CW11 1EQ
Recruiting
Research Site
Southampton, SO303JB
Withdrawn
Research Site
Swansea, SA6 6NL
Recruiting
Research Site
Weston-super-Mare, BS24 7PR
Recruiting
Research Site
Wolverhampton, WV10 0QP
Recruiting
Research Site
Woodbridge, IP136TH
Recruiting
Research Site
Yate, BS37 4AX
Recruiting

Other trials in United Kingdom

Denmark16 sites, 16 recruiting

Research Site
Aarhus, 8200
Recruiting
Research Site
Aarhus N, 8200
Recruiting
Research Site
Copenhagen, 2300
Recruiting
Research Site
Esbjerg, 6700
Recruiting
Research Site
Frederiksberg, 2000
Recruiting
Research Site
Gistrup, 9260
Recruiting
Research Site
Herlev, 2730
Recruiting
Research Site
Herning, 7400
Recruiting
Research Site
Hillerød, 3400
Recruiting
Research Site
Hjørring, 9800
Recruiting
Research Site
Holbæk, 4300
Recruiting
Research Site
Hvidovre, 2650
Recruiting
Research Site
Roskilde, 4000
Recruiting
Research Site
Slagelse, DK-4200
Recruiting
Research Site
Svendborg, 5700
Recruiting
Research Site
Viborg, 8800
Recruiting

Other trials in Denmark

Australia15 sites, 13 recruiting

Research Site
Adelaide, 5000
Recruiting
Research Site
Castle Hill, 2154
Recruiting
Research Site
Coffs Harbour, 02450
Recruiting
Research Site
Elizabeth Vale, 5112
Recruiting
Research Site
Fremantle, 6160
Recruiting
Research Site
Geelong, 3220
Recruiting
Research Site
Kingswood, 2747
Terminated
Research Site
Leabrook, 5068
Recruiting
Research Site
Maroubra, 2035
Recruiting
Research Site
Merewether, 2291
Recruiting
Research Site
Milton, 4064
Recruiting
Research Site
Mulgrave, 3170
Withdrawn
Research Site
Osborne Park, 6017
Recruiting
Research Site
Rockhampton, 4700
Recruiting
Research Site
Wollongong, 2500
Recruiting

Other trials in Australia

Romania15 sites, 15 recruiting

Research Site
Bacau, 600274
Recruiting
Research Site
Baia Mare, 430124
Recruiting
Research Site
Baia Mare, 430222
Recruiting
Research Site
Brasov, 500102
Recruiting
Research Site
Bucharest, 010507
Recruiting
Research Site
Bucharest, 010825
Recruiting
Research Site
Bucharest, 012296
Recruiting
Research Site
Bucharest, 020475
Recruiting
Research Site
Bucharest, 031818
Recruiting
Research Site
Bucharest, 050098
Recruiting
Research Site
Craiova, 200642
Recruiting
Research Site
Iași, 700515
Recruiting
Research Site
Ploieşti, 100179
Recruiting
Research Site
Satu Mare, 440055
Recruiting
Research Site
Târgu Mureş, 540136
Recruiting

Other trials in Romania

Spain15 sites, 15 recruiting

Research Site
A Coruña, 15006
Recruiting
Research Site
Barcelona, 08003
Recruiting
Research Site
Barcelona, 08036
Recruiting
Research Site
Barcelona, 08041
Recruiting
Research Site
Córdoba, 14004
Recruiting
Research Site
Córdoba, 14940
Recruiting
Research Site
L'Hospitalet de Llobregat, 08907
Recruiting
Research Site
Madrid, 28040
Recruiting
Research Site
Málaga, 29010
Recruiting
Research Site
Sant Joan Despí, 08970
Recruiting
Research Site
Santiago(A Coruña), 15706
Recruiting
Research Site
Seville, 41004
Recruiting
Research Site
Seville, 41071
Recruiting
Research Site
Valencia, 46010
Recruiting
Research Site
Vigo, 36312
Recruiting

Other trials in Spain

Turkey (Türkiye)15 sites, 14 recruiting

Research Site
Adana, 01130
Recruiting
Research Site
Afyonkarahisar, 03030
Recruiting
Research Site
Ankara, 06530
Recruiting
Research Site
Antalya, 07059
Recruiting
Research Site
Eskişehir, 26040
Recruiting
Research Site
Istanbul, 34303
Completed
Research Site
Istanbul, 34899
Recruiting
Research Site
Izmir, 35340
Recruiting
Research Site
Kahramanmaraş, 46100
Recruiting
Research Site
Kocaeli, 41001
Recruiting
Research Site
Kütahya, 43100
Recruiting
Research Site
Malatya, 44280
Recruiting
Research Site
Odunpazari, 26080
Not yet recruiting
Research Site
Samsun, 55270
Recruiting
Research Site
Sivas, 58140
Recruiting

Other trials in Turkey (Türkiye)

South Korea14 sites, 14 recruiting

Research Site
Bucheon-si, 14754
Recruiting
Research Site
Cheongju-si, 28644
Recruiting
Research Site
Daegu, 42601
Recruiting
Research Site
Seongnam-si, 13620
Recruiting
Research Site
Seoul, 02841
Recruiting
Research Site
Seoul, 03080
Recruiting
Research Site
Seoul, 06591
Recruiting
Research Site
Seoul, 08308
Recruiting
Research Site
Seoul, 120-752
Recruiting
Research Site
Seoul, 135-710
Recruiting
Research Site
Seoul, 5505
Recruiting
Research Site
Suwon, 16499
Recruiting
Research Site
Wŏnju, 26426
Recruiting
Research Site
Yangsan, 50612
Recruiting

Other trials in South Korea

Ukraine14 sites, 13 recruiting

Research Site
Chernivtsі, 58002
Recruiting
Research Site
Ivano-Frankivsk, 76018
Recruiting
Research Site
Kyiv, 01601
Recruiting
Research Site
Kyiv, 02081
Recruiting
Research Site
Kyiv, 03037
Recruiting
Research Site
Kyiv, 03151
Recruiting
Research Site
Kyiv, 03680
Recruiting
Research Site
Kyiv, 04050
Recruiting
Research Site
Ternopil, 46000
Withdrawn
Research Site
Ternopil, 46002
Recruiting
Research Site
Uzhhorod, 88014
Recruiting
Research Site
Vinnytsia, 21001
Recruiting
Research Site
Vinnytsia, 21029
Recruiting
Research Site
Zhytomyr, 100002
Recruiting

Other trials in Ukraine

Greece13 sites, 13 recruiting

Research Site
Athens, 11527
Recruiting
Research Site
Athens, 11528
Recruiting
Research Site
Athens, 12462
Recruiting
Research Site
Athens, 17562
Recruiting
Research Site
Chania, 73300
Recruiting
Research Site
Ioannina, 45110
Recruiting
Research Site
Ioannina, 45500
Recruiting
Research Site
Larissa, 41110
Recruiting
Research Site
Piraeus, 18454
Recruiting
Research Site
Piraeus, 18536
Recruiting
Research Site
Thessaloniki, 54636
Recruiting
Research Site
Thessaloniki, 54642
Recruiting
Research Site
Thessaloniki, 57001
Recruiting

Other trials in Greece

Philippines12 sites, 11 recruiting

Research Site
Angeles City, 2009
Recruiting
Research Site
Cebu, 6000
Recruiting
Research Site
Davao City, 8000
Recruiting
Research Site
Davao City, PH-8000
Recruiting
Research Site
Fuente Osmena Cebu City, 6000
Recruiting
Research Site
Iloilo City, 5000
Recruiting
Research Site
Las Piñas, 1742
Recruiting
Research Site
Lipa City, 4217
Recruiting
Research Site
Manadaluyong City, 1552
Suspended
Research Site
Puerto Princesa City, 5300
Recruiting
Research Site
Quezon City, 1100
Recruiting
Research Site
Roxas City, 5800
Recruiting

Other trials in Philippines

Sweden12 sites, 12 recruiting

Research Site
Gothenburg, 413 46
Recruiting
Research Site
Helsingborg, 252 21
Recruiting
Research Site
Huddinge, 141 86
Recruiting
Research Site
Lund, 222 21
Recruiting
Research Site
Lund, 222 42
Recruiting
Research Site
Mölndal, 431 80
Recruiting
Research Site
Norrköping, 603 79
Recruiting
Research Site
Stockholm, 113 61
Recruiting
Research Site
Stockholm, 117 27
Recruiting
Research Site
Stockholm, 118 83
Recruiting
Research Site
Uppsala, 751 85
Recruiting
Research Site
Uppsala, 75233
Recruiting

Other trials in Sweden

Thailand12 sites, 12 recruiting

Research Site
Bangkok, 10330
Recruiting
Research Site
Bangkok, 10700
Recruiting
Research Site
Banphaeo, 74120
Recruiting
Research Site
Bansuan, Muang, Chonburi, 20000
Recruiting
Research Site
Chiang Mai, 50200
Recruiting
Research Site
Dusit, 10300
Recruiting
Research Site
Hat Yai, 90110
Recruiting
Research Site
Khlong Luang, 12120
Recruiting
Research Site
Khon Kaen, 40002
Recruiting
Research Site
Muang, 22000
Recruiting
Research Site
Naimuang, 30000
Recruiting
Research Site
Ubonratchathani, 34000
Recruiting

Other trials in Thailand

Israel11 sites, 11 recruiting

Research Site
Be’er Ya‘aqov, 70300
Recruiting
Research Site
Beersheba, 8410101
Recruiting
Research Site
Haifa, 3109601
Recruiting
Research Site
Herzelia, 4640200
Recruiting
Research Site
Holon, 5822012
Recruiting
Research Site
Jerusalem, 91120
Recruiting
Research Site
Petah Tikva, 4941492
Recruiting
Research Site
Ramat Gan, 52621
Recruiting
Research Site
Tel Aviv, 61480
Recruiting
Research Site
Tel Aviv, 6423906
Recruiting
Research Site
Tel Aviv, 64239
Recruiting

Other trials in Israel

Malaysia11 sites, 10 recruiting

Research Site
Alor Star, 05460
Recruiting
Research Site
Johor Bahru, 80100
Recruiting
Research Site
Kota Samarahan, 94300
Recruiting
Research Site
Kuala Terengganu, 20400
Recruiting
Research Site
Kuantan, 25100
Recruiting
Research Site
Kuching, 93586
Recruiting
Research Site
Malacca, 78300
Withdrawn
Research Site
Rawang, 48050
Recruiting
Research Site
Sarawak Miri, 98000
Recruiting
Research Site
Seri Manjung, 32040
Recruiting
Research Site
Sungai Buloh, 47000
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Other trials in Malaysia

Vietnam11 sites, 10 recruiting

Research Site
Can Tho, 900000
Recruiting
Research Site
Hà Nội, 100000
Recruiting
Research Site
Haiphong, 180000
Recruiting
Research Site
Hanoi, 10000
Recruiting
Research Site
Ho Chi Minh City, 700000
Recruiting
Research Site
Ho Chi Minh City, 700000
Withdrawn
Research Site
Ho Chi Minh City, 70000
Recruiting
Research Site
Hochiminh City, 700000
Recruiting
Research Site
Huế, 530000
Recruiting
Research Site
Rach Gia, 920000
Recruiting
Research Site
Vĩnh Yên, 280000
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About this study

Official title: A Phase III, Randomised, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on the Risk of Incident Heart Failure and Cardiovascular Death

The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent is required for the optional pre-screening period. The pre-screening assessments do not replace the full screening tests at Visit 1.

Upon entering the screening period, all consented participants (after signature of screening ICF) will be screened during an up to 14-day screening period. Participants who meet all screening inclusion/exclusion criteria but are not treated with SGLT2i or are treated for less than 4 weeks will enter a run-in period with dapagliflozin 10 mg once daily for at least 4 weeks (and not more than 6 weeks) before randomisation.

Site visits will take place at approximately 2-, 4-, 8-, 16-, and 34-weeks following randomisation. Thereafter visits will occur approximately every 4 months.

The study closure procedures will be initiated when the predetermined number of the first secondary endpoint events (ie, the composite of hospitalisation for HF or CV death) is predicted to have occurred i.e., the PACD.

In case of premature discontinuation of the blinded study intervention, participants will remain in the study. Unless a participant meets the dapagliflozin specific discontinuation criteria, they will continue to receive open label dapagliflozin 10 mg. It is important that the scheduled study visits and data collection continue according to the study protocol.

Conditions: Heart Failure
Being tested: Baxdrostat and dapagliflozin, Placebo and dapagliflozin
Keywords: Heart failure: Baxdrostat; Dapagliflozin; cardiovascular
Medical subject headings: Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Baxdrostat and dapagliflozinDrug
Also called Baxdrostat CIN-107
baxdrostat tablet and dapagliflozin tablet
Placebo and dapagliflozinOther
placebo tablet and dapagliflozin tablet

Study groups in NCT06677060
Study group	Role	What they receive
Baxdrostat/Dapagliflozin	Experimental	Participants randomised to the baxdrostat/dapagliflozin arm will initially receive a dose of baxdrostat lower dose and dapagliflozin. For participants that meet the up-titration criteria, baxdrostat may be up-titrated to higher dose. Receives: Drug: Baxdrostat and dapagliflozin
Placebo/Dapagliflozin	Experimental	Patients will receive a dose of dapagliflozin in combination with matching placebo Receives: Other: Placebo and dapagliflozin

What is being measured

The primary outcome is the main question the study is designed to answer.

To determine if baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of an HF event or CV death
Time to first occurrence of any of the components of the composite of:
- Hospitalisation for HF
- HF without hospitalisation
- CV death
Measured: Event driven; Up to 38 months

Secondary outcomes (5)

To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of hospitalisation for HF or CV death
Time to first occurrence of any of the components of the composite of:
- Hospitalisation for HF
- CV death
Measured: Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of HF events
Time to first occurrence of any of the components of the composite of:
- Hospitalisation for HF
- HF without hospitalisation
Measured: Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of CV death
Time to CV death
Measured: Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of all-cause mortality
Time to all-cause death
Measured: Event driven; Up to 38 months
To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of 4-point MACE (CV death, MI, stroke, and hospitalisation for HF)
Time to first occurrence of any of the components of the composite of:
- CV death
- MI
- Stroke
- Hospitalisation for HF
Measured: Event driven; Up to 38 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

14 Mar 202517 Dec 2029

First posted6 Nov 2024
Study start14 Mar 2025
Primary completion17 Dec 2029 (estimated)
Study completion17 Dec 2029 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (1)Papers the sponsor has linked to this study.
Other trials for Heart FailureStudies of the same condition, open and under way.
More trials run by AstraZenecaThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 3
Primary purpose: Prevention
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind
Who is masked: Participant, Care provider, Investigator, Outcomes assessor
Enrolment: 11,300 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06677060
Sponsor's protocol ID: D6973C00001
Other IDs: 2024-514506-32-00
Acronym: Prevent-HF
Status last verified: Oct 2026
First submitted: 5 Nov 2024
Last updated: 21 Oct 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: Yes
FDA-regulated device: No
Individual data sharing: Yes: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.

Publications

Dwyer JP, Maklad N, Vedin O, Monyak J, Myte R, Chertow GM, Heerspink HJL, Little DJ. Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2026 Feb 1;37(2):299-311. doi: 10.1681/ASN.0000000849. Epub 2025 Sep 6.
PubMed 40913594

Interested in taking part?

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

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