Clinical trials: Cardiovascular Disease, Obesity
Obesity, Type 2 Diabetes
Activity and Metformin Intervention in Obese Adolescents
The purpose of this study is to assess the sustainability of a two-year intervention aimed at improving body mass index (BMI) and metabolic and vascular health in obese youth.
- Trial name
- REACH (NCT00934570)
- Testing
- Metformin and standard exercise, Metformin Intensive exercise, Intensive exercise
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obesity, Overweight
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects
The purpose of this Phase 3b study is to assess the effects of combination therapy with naltrexone SR/bupropion SR (NB) used in conjunction with a comprehensive lifestyle intervention (CLI) and in a manner consistent with its…
- Trial name
- NCT01764386
- Testing
- NB, CLI, Usual Care
- Where
- 15 sites in United States
- Volunteers
- 242 people
- Sponsor
- Orexigen Therapeutics, Inc
Diabetes Mellitus, Type II, Overweight and Obesity
Microclinic Social Induction Pilot Intervention for Diabetes and Obesity Management in Qatar
The purpose of the study is to pilot-phase test the effectiveness of the microclinic social induction model and its effects on behavioral and metabolic outcomes in different levels of social and familial relationships in Qatar.
- Conditions
- Diabetes Mellitus, Type II, Overweight and Obesity, Hypertension, Behavioral Lifestyle Change
- Trial name
- NCT02175537
- Testing
- Microclinic Social Induction Diabetes and Obesity Program
- Where
- Qatar
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Microclinic International
Hypertension, Diabetes
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for…
- Conditions
- Hypertension, Diabetes, Postpartum, Pregnancy
- Trial name
- NCT06557005
- Testing
- Facilitated Transition to Primary Care
- Where
- United States
- Volunteers
- 1,320 people
- Sponsor
- Massachusetts General Hospital
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Overweight and Obesity, Weight Loss
Exercise Training and Time-restricted Feeding in Overweight and Obese Adults
Overweight and obesity prevalence in adolescents and adults continues to remain significantly high in the United States. While diet and exercise improve many consequences of obesity, dietary strategies are not always nutrient…
- Trial name
- NCT03823872
- Testing
- Time restricted feeding, Normal feeding
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kyle Hackney
Overweight, Obese
Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)
Abdominal obesity, which is affected by a lack of physical activity and excess weight, put people at an increased risk of cardiovascular disease.
- Conditions
- Overweight, Obese, Sedentary, Abdominal Obesity
- Trial name
- SHAPE5 (NCT00990457)
- Testing
- Weight Loss Diets Plus Exercise
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Tongzhou
The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- PKUBC-T (NCT03814395)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,426 people, healthy volunteers welcome
- Sponsor
- Peking University
Postprandial Lipaemia, Postprandial Incretins
Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects
The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.
- Conditions
- Postprandial Lipaemia, Postprandial Incretins, Postprandial Inflammation
- Trial name
- NCT00809874
- Testing
- Casein, Whey Isolate, Whey Hydrolysate
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Metabolic Disease, Cardiovascular Diseases
HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking
This clinical trial investigates whether incorporating stair walking into daily routines improves physical health in adults at risk of lifestyle-related conditions such as hypertension, type 2 diabetes, and cardiovascular…
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Hypertension, Obesity and Overweight
- Trial name
- HYPERWALK (NCT06952348)
- Testing
- Stair and brisk walking combined, Brisk walking, Standard care
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Cardiovascular Diseases, Heart Diseases
Weight Loss Maintenance (WLM)
To determine the effectiveness of continuous patient contact on weight loss maintenance.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- WLM (NCT00054925)
- Testing
- Personal contact (PC), Interactive technology (IT)
- Volunteers
- 1,685 people
- Sponsor
- Duke University
Cardiovascular Diseases, Obesity
Diet, Obesity and Cardiovascular Risk Study
Controversy exists about the role of dietary glycemic index (GI) and fat content and cardiovascular risk. Our aim was to assess the long term effects of altering dietary GI, carbohydrate, and fat on body weight, lipids, glucose…
- Trial name
- NCT02379897
- Testing
- Diet
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obesity, Heart Diseases
The Effect of Xenical on Weight and Risk Factors
The purpose of this study is to determine the effect of using the weight loss medication Xenical (generic name - orlistat) on weight loss and change in heart disease risk factors in patients of the Healthy Heart Program Lipid…
- Trial name
- NCT00152360
- Testing
- Orlistat
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Excessive Weight Gain in Pregnancy as Antepartum Condition, Obesity
Be Healthy in Pregnancy (B-HIP): A Trial to Study Nutrition and Exercise Approaches for Healthy Pregnancy
Weight gained during pregnancy is referred to as gestational weight gain (GWG). Excess GWG is a widespread problem that occurs in 55-75% of Canadian women who enter pregnancy overweight or obese (a group that represents over 50 %…
- Conditions
- Excessive Weight Gain in Pregnancy as Antepartum Condition, Obesity, Weight Gain, Type 2 Diabetes
- Trial name
- BHIP (NCT01693510)
- Testing
- Exercise and Nutrition Intervention
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Effect of a Traditional Dietary Intervention on Diabetes Mellitus and Cardiovascular Disease Risk Factors in a First Nation Community: A Pilot Study
The purpose of this study is to evaluate whether or not a traditional First Nations diet (high protein) and/or a dietary intervention based upon current Canadian dietary recommendations (high carbohydrate/high fiber) effects risk…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- SLHDP (NCT00707460)
- Testing
- Dietary Intervention (Macronutrient composition)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sarcopenia, Metabolic Disease
Effects of Milk Protein Concentrate on Overall Health During Weight Loss in Overweight/Obese Adults
. The purpose of this study is to examine the effects of eating a larger amount of dairy-based protein on risk factors for metabolic syndrome
- Conditions
- Sarcopenia, Metabolic Disease, High Blood Pressure
- Trial name
- S28 (NCT01692860)
- Testing
- Energy Restriction
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Purdue University
Obesity, Diabetes
The Effect of Macronutrients in the Diet on Digestive and Cardiovascular Health
This study examined the effect of a 5-day HFD supplemented with specific fatty acids on gastrointestinal transit, appetite, food intake and substrate utilization.
- Conditions
- Obesity, Diabetes, Cardiovascular Diseases
- Trial name
- NCT01510223
- Testing
- Olive oil, Olive oil and fish powder, Olive oil and macadamia oil
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Hypertension
Relationship of Epicardial Adiposity With Sedentary Time, Physical Activity and Performance in Hypertensives
Epicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals.
- Trial name
- NCT05890989
- Testing
- EPICARDIAL ADIPOSIS TISSUE AND PHYSICAL PERFORMANCE MEASUREMENT
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Obesity, Metabolic Syndrome
Strawberry Consumption in Overweight and Obese Individuals
Our proposal represents an integrated approach to determining the cardiovascular and metabolic effects of strawberry consumption in adults who have high risk for cardiometabolic disease.
- Trial name
- NCT04094103
- Testing
- Active strawberry powder, Mixed strawberry powder
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Carl Ade, M.S., Ph.D.
Type 2 Diabetes, Hypertension
Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes
Insulin resistance has been implicated as the central pathogenetic feature of cardiovascular risk factor cluster that includes hypertension, impaired glucose tolerance, diabetes, dyslipidemia, and hemostatic disorders.
- Trial name
- NCT00738023
- Testing
- Rosiglitazone, Normal saline 0.9%, Intralipid 20%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emory University
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